Inter-observer reproducibility of endometrial cytology by the Osaki Study Group method: utilising the Becton Dickinson SurePath™liquid-based cytology

Cytopathology ◽  
2016 ◽  
Vol 27 (6) ◽  
pp. 472-478 ◽  
Author(s):  
Y. Norimatsu ◽  
T. Yamaguchi ◽  
T. Taira ◽  
H. Abe ◽  
H. Sakamoto ◽  
...  
Keyword(s):  
Group Method ◽  
Study Group ◽  
Becton Dickinson ◽  
Liquid Based Cytology ◽  
Endometrial Cytology

Evaluation of Endometrial Cytology Prepared with the Becton Dickinson SurePath™ Method: A Pilot Study by the Osaki Study Group

2014 ◽  
Vol 58 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Kenji Yanoh ◽  
Yoshiaki Norimatsu ◽  
Satoru Munakata ◽  
Toshiya Yamamoto ◽  
Yutaka Nakamura ◽  
...  
Keyword(s):  
Pilot Study ◽  
Study Group ◽  
Becton Dickinson ◽  
Endometrial Cytology

General practitioners and clinical pharmacology

1989 ◽  
Vol 4 (4) ◽  
pp. 241-244
Author(s):  
P. Lemoine
Keyword(s):  
Clinical Pharmacology ◽  
General Practitioners ◽  
Field Studies ◽  
Discussion Group ◽  
Group Method ◽  
Study Group ◽  
Test Drug ◽  
Monthly Basis ◽  
One Year ◽  
The One

SummaryIt is difficult to undertake field studies with non marketed psychotropic drugs because of two apparently contradictory conditions : on the one hand, the methodology has to be rigorously controlled, and on the other hand, such studies have to be carried out in their future environment by general practitioners (GPs). Bearing in mind the lack of training and experience regarding this kind of approach, the author adopted a discussion group method according to the techniques developed by M. Balint. The study group comprised five GPs, a clinical pharmacology expert and a doctor from the pharmaceutical laboratory which had developed the test drug. These persons met on a monthly basis over a one year period. In the present paper, the author indicates the benefits of such a methodology, based on six years’ experience and several trials, with special emphasis placed on the pedagogical aspects.

Comparison between the conventional reporting format and the Osaki Study Group reporting format for endometrial cytology

2021 ◽  
Vol 60 (5) ◽  
pp. 253-259
Author(s):  
Kosei SHIRAHAMA ◽  
Yuichiro SATO ◽  
Kazuaki KIYOYAMA ◽  
Hiroshi NOGUCHI ◽  
Tohru HAYASHI ◽  
...  
Keyword(s):  
Study Group ◽  
Endometrial Cytology

scholarly journals A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

2019 ◽  
Vol 64 (3) ◽  
pp. 195-207 ◽  
Author(s):  
Yoshiaki Norimatsu ◽  
Kenji Yanoh ◽  
Yasuo Hirai ◽  
Tetsuji Kurokawa ◽  
Tadao K. Kobayashi ◽  
...  
Keyword(s):  
Diagnostic Procedure ◽  
Molecular Diagnostic ◽  
The Past ◽  
Number Of Factors ◽  
Standardized Terminology ◽  
Liquid Based Cytology ◽  
Endometrial Cytology

The adoption of endometrial cytology as a diagnostic procedure has been hampered in the past by difficulties arising in interpreting the cellular findings due to a number of factors (such as excess blood, cellular overlapping, and the complex physiology of endometrium). Recently, the use of liquid-based cytology (LBC), with its ability to remove blood and mucus and to distribute cells uniformly in a thin layer on the slide, has provided an opportunity to reevaluate the role of endometrial cytology. LBC samples are easier to screen compared to conventional ones, due to a smaller screening area and an excellent quality of cell preparations. LBC by using peculiar cytoarchitectural features is a useful tool in the cellular diagnosis and follow-up of abnormalities, which, however, remains complementary to histopathology and to the emerging molecular diagnostic cytopathology. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure. Herein, we also summarize the process and rationale by which updates were made to the standardized terminology in 2018 and outline the contents of the new Bethesda-style classification (the Yokohama system) for the endometrial cytology.

Morphological Differences between Liquid-Based Cytology and Conventional Preparation in Endometrial Endometrioid Carcinoma Grade 1 and Grade 3, and the Differentiation of Grades in Each Method

2021 ◽  
pp. 1-8
Author(s):  
Hirokazu Odashima ◽  
Haruhiko Yoshioka ◽  
Kasumi Ota ◽  
Yuya Goto ◽  
Misuzu Noro ◽  
...  
Keyword(s):  
Endometrioid Carcinoma ◽  
Number Of Clusters ◽  
Cell Image ◽  
Morphological Findings ◽  
Number Of Layers ◽  
Liquid Based Cytology ◽  
Morphological Differences ◽  
Grade 3 ◽  
Screening Errors ◽  
Endometrial Cytology

Introduction: Direct smearing preparation (conventional preparation [CP]) has been widely used for endometrial cytology in Japan. In CP, sampling and screening errors are problematic. In liquid-based cytology preparation (LBC), the problems of CP can be solved. But there is a problem that cytological findings of LBC are different from those of CP. The purpose of this study was to evaluate the differences of morphological findings of endometrial cytology between LBC and CP, and the usefulness of the endometrial LBC to differentiate endometrioid carcinoma grade 1 (G1) from grade 3 (G3). Methods: Thirteen cases of endometrioid carcinoma G1, and 5 cases of G3 collected by the Softcyte device and prepared by LBC and CP (split specimen) were used. We focused on the following items: (1) the number of clusters per cm2, (2) the number of layers of clusters, (3) area of clusters, (4) perimeter of clusters, (5) roundness of clusters, (6) complexity of clusters, (7) area of nucleus, (8) perimeter of nucleus, (9) roundness of nucleus, (10) complexity of nucleus, (11) area of nucleolus, and (12) nucleolus-nucleus ratio (N/N). Results: Compared with CP, the number of clusters and layers of the clusters in LBC were significantly larger in G1. The area and perimeters of the clusters and the nucleus were significant smaller, and the N/N ratio was greater in LBC than that in CP in both G1 and G3. Regarding morphological differences between G1 and G3 in LBC and CP, the number of layers was significantly larger in G1 than in G3 in LBC and CP. The area of the clusters in LBC was significantly larger in G1 than in G3. The area and perimeters of the nucleus in CP and the area of the nucleolus and N/N ratio in LBC and CP were significantly smaller in G1 than in G3. Conclusion: In the endometrial cytology, it became clear that the cell image was different between LBC and CP and between G1 and G3. By microscopic examination understanding the characteristics of the cell image in LBC, endometrial LBC could be useful to diagnose endometrial carcinoma.

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