scholarly journals Measures of test performance for high-risk HPV tests and triage cytology and the importance of follow-up of women with positive test results

Cytopathology ◽  
2014 ◽  
Vol 25 (4) ◽  
pp. 264-268
Author(s):  
H. Llewellyn
2015 ◽  
Vol 4 (5) ◽  
pp. 261-266 ◽  
Author(s):  
Anna Woodard ◽  
R. Marshall Austin ◽  
Zaibo Li ◽  
Joseph Beere ◽  
Chengquan Zhao
Keyword(s):  
Hpv 16 ◽  
Hpv Test ◽  

2008 ◽  
Vol 132 (12) ◽  
pp. 1874-1881 ◽  
Author(s):  
Sudeshna Bandyopadhyay ◽  
R. Marshall Austin ◽  
David Dabbs ◽  
Chengquan Zhao

Abstract Context.—Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). Objective.—To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in females with ASC-H Papanicolaou (Pap) test results. Design.—High-risk HPV prevalence and histopathologic follow-up data on 1187 females with ASC-H ThinPrep Pap test (TPPT) and hrHPV test results were analyzed. Results.—ASC-H was reported in 1646 (0.006%) of 277 400 (270 338 TPPT and 7062 conventional) Pap test results. The difference in ASC-H detection rates between TPPTs and conventional Pap smears was statistically significant (0.60% vs 0.38%; P = .02). High-risk HPV was detected in 589 (49.6%) of 1187 females with ASC-H TPPT and hrHPV testing. The hrHPV DNA–positive rate in females younger than 40 years was 54.7%, significantly higher than the 36.5% in women 40 years and older. Among 505 females with histopathologic follow-up, cervical intraepithelial neoplasia 2/3 was identified in 32.7% of hrHPV-positive females compared with 1.2% in hrHPV-negative females. The sensitivity, specificity, positive predictive value, and negative predictive value of ASC-H cytology in conjunction with hrHPV DNA testing results for detection of cervical intraepithelial neoplasia 2/3 were 96.1% versus 100.0%, 54.0% versus 68.4%, 35.8% versus 20.8%, and 98.1% versus 100.0% in females younger than 40 years and women 40 years and older, respectively. Conclusions.—Our data suggest that reflex hrHPV testing is a highly useful option for women with ASC-H Pap tests. Females with ASC-H and negative hrHPV testing may be more efficiently managed by follow-up with regular Pap and hrHPV testing rather than universal colposcopy, especially for women 40 years and older.


2018 ◽  
Vol 126 (8) ◽  
pp. 525-532 ◽  
Author(s):  
Huina Zhang ◽  
Kavita R. Varma ◽  
Min Han ◽  
Jonee Matsko ◽  
Chengquan Zhao
Keyword(s):  

2014 ◽  
Vol 134 (8) ◽  
pp. 843-851 ◽  
Author(s):  
Karin Annertz ◽  
Kerstin Rosenquist ◽  
Gunilla Andersson ◽  
Helene Jacobsson ◽  
Bengt Göran Hansson ◽  
...  

2019 ◽  
Vol 154 (2) ◽  
pp. 345-353 ◽  
Author(s):  
Wending Li ◽  
Yifan Meng ◽  
Yi Wang ◽  
Xiaodong Cheng ◽  
Chen Wang ◽  
...  

2015 ◽  
Vol 123 (7) ◽  
pp. 421-427 ◽  
Author(s):  
Xiang Tao ◽  
Christopher C. Griffith ◽  
Xiangrong Zhou ◽  
Zhiheng Wang ◽  
Yabin Yan ◽  
...  

2001 ◽  
Vol 84 (6) ◽  
pp. 796-801 ◽  
Author(s):  
M A E Nobbenhuis ◽  
C J L M Meijer ◽  
A J C van den Brule ◽  
L Rozendaal ◽  
F J Voorhorst ◽  
...  

2013 ◽  
Vol 58 (1) ◽  
pp. 161-167 ◽  
Author(s):  
Arundhati Rao ◽  
Maria Teresa Sandri ◽  
Mario Sideri ◽  
Stephen Young ◽  
Abha Sharma ◽  
...  

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