History of high-risk HPV and Pap test results in a large cohort of patients with invasive cervical carcinoma: Experience from the largest women's hospital in China

2015 ◽  
Vol 123 (7) ◽  
pp. 421-427 ◽  
Author(s):  
Xiang Tao ◽  
Christopher C. Griffith ◽  
Xiangrong Zhou ◽  
Zhiheng Wang ◽  
Yabin Yan ◽  
...  
Keyword(s):  
High Risk ◽  
Cervical Carcinoma ◽  
Pap Test ◽  
Large Cohort ◽  
Test Results ◽  
Invasive Cervical Carcinoma ◽  
History Of ◽  
High Risk Hpv

Prior High-Risk HPV Testing and Pap Test Results of 58 Invasive Cervical Carcinomas Diagnosed in 2012

2013 ◽  
Vol 2 (1) ◽  
pp. S3-S4
Author(s):  
Chengquan Zhao ◽  
Ritu Nayar ◽  
Angelique W. Levi ◽  
Barbara Winkler ◽  
Ann T. Moriarty ◽  
...  
Keyword(s):  
High Risk ◽  
Pap Test ◽  
Hpv Testing ◽  
Test Results ◽  
Cervical Carcinomas ◽  
High Risk Hpv

Screening Test Results Associated With Cancer Diagnoses in 287 Women With Cervical Squamous Cell Carcinoma

2012 ◽  
Vol 136 (12) ◽  
pp. 1533-1540 ◽  
Author(s):  
Zaibo Li ◽  
R. Marshall Austin ◽  
Ming Guo ◽  
Chengquan Zhao
Keyword(s):  
Polymerase Chain Reaction ◽  
High Risk ◽  
Pap Test ◽  
Cervical Squamous Cell Carcinoma ◽  
Test Results ◽  
Abnormal Cytology ◽  
Chain Reaction ◽  
Liquid Based Cytology ◽  
Polymerase Chain ◽  
High Risk Hpv

Context.—The limitations of newer cervical screening tests are still being studied. Objective.—To investigate those limitations, we conducted a retrospective review of 287 cases of cervical squamous cell carcinoma (SCC). Design.—A search through 5 years of records identified 287 women with cervical SCC diagnoses. Clinical history, histopathology, and liquid-based cytology (ThinPrep) and Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) results were documented. Polymerase chain reaction HPV tests were performed on SCC tissues with prior negative HC2 results. Results.—Of 287 women, 156 (54.4%) had abnormal cytology results, and 75 (26.1%) had abnormal clinical findings triggering tissue diagnoses of SCC. Among 156 patients with abnormal Papanicolaou (Pap) test results, more-seriously abnormal Pap test results were reported in 142 women (91.1%). Among 31 women with Pap and HC2 HPV cotesting within 1 year of SCC diagnoses, 28 (90%) were Pap+/HPV+, 2 (15.5%) were Pap+/HPV−, and 1 (3%) was Pap−/HPV−. Two of 3 women with negative HC2 results before SCC diagnosis had abnormal Pap results; 1 had negative Pap reports with questionable lesional cells mimicking atrophy. In all 3 cases of SCC with negative HC2 results, HPV-18 was detected; in 2 cases (66%), HPV-16 was also detected. Conclusions.—Although abnormal cytology preceded most SCC diagnoses, about one-third of patients were referred for diagnostic testing because of clinical suspicion alone. Among 31 SCC cases with liquid-based cytology and high-risk HPV cotest results less than 1 year before SCC diagnoses, 2 patients (6.5%) had Pap+/HPV− results, and 1 patient (3.2%) had Pap−/HPV− results. Polymerase chain reaction detected high-risk HPV DNA in tumor tissues of 3 SCC cases with recent HC2− results.

Adjunctive Human Papillomavirus DNA Testing Is a Useful Option in Some Clinical Settings for Disease Risk Assessment and Triage of Females With ASC-H Papanicolaou Test Results

2008 ◽  
Vol 132 (12) ◽  
pp. 1874-1881 ◽  
Author(s):  
Sudeshna Bandyopadhyay ◽  
R. Marshall Austin ◽  
David Dabbs ◽  
Chengquan Zhao
Keyword(s):  
Risk Assessment ◽  
Human Papillomavirus ◽  
High Risk ◽  
Disease Risk ◽  
Pap Test ◽  
Intraepithelial Neoplasia ◽  
Test Results ◽  
Dna Testing ◽  
High Risk Hpv

Abstract Context.—Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). Objective.—To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in females with ASC-H Papanicolaou (Pap) test results. Design.—High-risk HPV prevalence and histopathologic follow-up data on 1187 females with ASC-H ThinPrep Pap test (TPPT) and hrHPV test results were analyzed. Results.—ASC-H was reported in 1646 (0.006%) of 277 400 (270 338 TPPT and 7062 conventional) Pap test results. The difference in ASC-H detection rates between TPPTs and conventional Pap smears was statistically significant (0.60% vs 0.38%; P = .02). High-risk HPV was detected in 589 (49.6%) of 1187 females with ASC-H TPPT and hrHPV testing. The hrHPV DNA–positive rate in females younger than 40 years was 54.7%, significantly higher than the 36.5% in women 40 years and older. Among 505 females with histopathologic follow-up, cervical intraepithelial neoplasia 2/3 was identified in 32.7% of hrHPV-positive females compared with 1.2% in hrHPV-negative females. The sensitivity, specificity, positive predictive value, and negative predictive value of ASC-H cytology in conjunction with hrHPV DNA testing results for detection of cervical intraepithelial neoplasia 2/3 were 96.1% versus 100.0%, 54.0% versus 68.4%, 35.8% versus 20.8%, and 98.1% versus 100.0% in females younger than 40 years and women 40 years and older, respectively. Conclusions.—Our data suggest that reflex hrHPV testing is a highly useful option for women with ASC-H Pap tests. Females with ASC-H and negative hrHPV testing may be more efficiently managed by follow-up with regular Pap and hrHPV testing rather than universal colposcopy, especially for women 40 years and older.

scholarly journals Prior high-risk HPV testing and Pap test results for 427 invasive cervical cancers in China's largest CAP-certified laboratory

2015 ◽  
Vol 123 (7) ◽  
pp. 428-434 ◽  
Author(s):  
Baowen Zheng ◽  
Zaibo Li ◽  
Christopher C. Griffith ◽  
Shanshan Yan ◽  
Congde Chen ◽  
...  
Keyword(s):  
High Risk ◽  
Pap Test ◽  
Hpv Testing ◽  
Test Results ◽  
Cervical Cancers ◽  
High Risk Hpv

Prevalence of HPV 16/18 genotypes and histopathologic follow-up outcomes in women with negative cytology and positive high-risk HPV test results

2015 ◽  
Vol 4 (5) ◽  
pp. 261-266 ◽  
Author(s):  
Anna Woodard ◽  
R. Marshall Austin ◽  
Zaibo Li ◽  
Joseph Beere ◽  
Chengquan Zhao
Keyword(s):  
High Risk ◽  
Test Results ◽  
Hpv 16 ◽  
Hpv Test ◽  
High Risk Hpv

scholarly journals HPV and Other Microbiota; Who’s Good and Who’s Bad: Effects of the Microbial Environment on the Development of Cervical Cancer—A Non-Systematic Review

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 714
Author(s):  
Matthias Läsche ◽  
Horst Urban ◽  
Julia Gallwas ◽  
Carsten Gründker
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
High Risk ◽  
Cervical Carcinoma ◽  
Hpv Infection ◽  
Human Papillomaviruses ◽  
Inflammatory Reactions ◽  
Metabolic Signalling ◽  
Microbial Environment ◽  
High Risk Hpv

Cervical cancer is responsible for around 5% of all human cancers worldwide. It develops almost exclusively from an unsolved, persistent infection of the squamocolumnar transformation zone between the endo- and ecto-cervix with various high-risk (HR) human papillomaviruses (HPVs). The decisive turning point on the way to persistent HPV infection and malignant transformation is an immune system weakened by pathobionts and oxidative stress and an injury to the cervical mucosa, often caused by sexual activities. Through these injury and healing processes, HPV viruses, hijacking activated keratinocytes, move into the basal layers of the cervical epithelium and then continue their development towards the distal prickle cell layer (Stratum spinosum). The microbial microenvironment of the cervical tissue determines the tissue homeostasis and the integrity of the protective mucous layer through the maintenance of a healthy immune and metabolic signalling. Pathological microorganisms and the resulting dysbiosis disturb this signalling. Thus, pathological inflammatory reactions occur, which manifest the HPV infection. About 90% of all women contract an HPV infection in the course of their lives. In about 10% of cases, the virus persists and cervical intra-epithelial neoplasia (CIN) develops. Approximately 1% of women with a high-risk HPV infection incur a cervical carcinoma after 10 to 20 years. In this non-systematic review article, we summarise how the sexually and microbial mediated pathogenesis of the cervix proceeds through aberrant immune and metabolism signalling via CIN to cervical carcinoma. We show how both the virus and the cancer benefit from the same changes in the immune and metabolic environment.

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