Aneurysmal fibrous histiocytomas with recurrent rearrangement of the PRKCD gene and LAMTOR1-PRKCD fusions

2018 ◽  
Vol 45 (12) ◽  
pp. 966-968 ◽  
Author(s):  
Jaroslaw J. Jedrych ◽  
Sekhar Duraisamy ◽  
Arivarasan Karunamurthy
Keyword(s):  
Fibrous Histiocytomas

Fibrous histiocytomas of the soft palate

1989 ◽  
Vol 18 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Robert J. Fieldman ◽  
Todd A. Morrow
Keyword(s):  
Soft Palate ◽  
Fibrous Histiocytomas

Malignant fibrous histiocytomas induced in rats by polymers

1984 ◽  
Vol 108 (3) ◽  
pp. 364-365 ◽  
Author(s):  
Akihiko Maekawa ◽  
Toshiaki Ogiu ◽  
Hiroshi Onodera ◽  
Kyoko Furuta ◽  
Chiaki Matsuoka ◽  
...  
Keyword(s):  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas

ASK1(MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications

2004 ◽  
Vol 40 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Frédéric Chibon ◽  
Odette Mariani ◽  
Josette Derré ◽  
Aline Mairal ◽  
Jean-Michel Coindre ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas

Vulvar sarcoma outcomes by histologic subtype: a Surveillance, Epidemiology, and End Results (SEER) database review

2020 ◽  
Vol 30 (8) ◽  
pp. 1118-1123
Author(s):  
Sarah Johnson ◽  
Malte Renz ◽  
Lindsay Wheeler ◽  
Elisabeth Diver ◽  
Oliver Dorigo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Seer Database ◽  
Disease Specific Survival ◽  
Histologic Subtype ◽  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas ◽  
Disease Specific ◽  
Positive Lymph Nodes ◽  
End Results

ObjectiveVulvar cancers account for 5% of all gynecologic malignancies; only 1%–3% of those vulvar cancers are primary vulvar sarcomas. Given the rarity of vulvar sarcomas, outcome data specific to histopathologic subtypes are sparse. The aim of this study was to identify clinical and pathologic factors of primary vulvar sarcomas that are associated with survival and may inform treatment decisions.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was searched for women diagnosed with vulvar sarcoma between 1973 and 2018. We identified 315 patients and reviewed their demographic, clinicopathologic, surgical, and survival information. Statistical analyses included χ2 and t-tests, Kaplan–Meier survival, and Cox regression analyses.ResultsThe most common histopathologies of vulvar sarcomas were dermatofibrosarcomas (85/315, 27%) and leiomyosarcomas (72/315, 22.9%). Rhabdomyosarcomas (18/315, 5.7%), liposarcomas (16/315, 5.1%), and malignant fibrous histiocytomas (16/315, 5.1%) were less frequent. The majority of patients underwent surgery (292/315, 92.7%), which included lymph node dissections in 21.6% (63/292). Survival and lymph node involvement varied significantly with histologic subtype. The 5-year disease-specific survival for dermatofibrosarcomas, liposarcomas, and fibrosarcomas was 100% and only 60.3% and 62.5% for malignant fibrous histiocytomas and rhabdomyosarcomas, respectively. None of the patients with (dermato)fibrosarcomas, liposarcomas, or leiomyosarcomas had positive lymph nodes, in contrast to rhabdomyosarcomas and malignant fibrous histiocytomas with 77.8% and 40% positive lymph nodes, respectively. The 5-year disease-specific survival for women with positive lymph nodes was 0%.ConclusionsVulvar sarcomas are heterogeneous with survival highly dependent on the histopathologic subtype. While surgical excision is the mainstay of treatment for all vulvar sarcomas, staging lymphadenectomy should be deferred for (dermato)fibrosarcomas, liposarcomas, and leiomyosarcomas as there were no cases of lymph nodes metastases.

Fibrous Histiocytoma of the Trachea

1978 ◽  
Vol 87 (5_suppl) ◽  
pp. 2-4 ◽  
Author(s):  
Seymour R. Cohen ◽  
Benjamin H. Landing ◽  
Hart Isaacs
Keyword(s):  
Fibrous Histiocytoma ◽  
Female Child ◽  
Middle Lobe ◽  
Benign Tumors ◽  
Endoscopic Removal ◽  
Respiratory Obstruction ◽  
Sclerosing Hemangioma ◽  
Fibrous Histiocytomas ◽  
Right Middle Lobe

Intratracheal tumors are rare in children. A case is reported of a two-year-old female child with a fibrous histiocytoma of the trachea which caused severe respiratory obstruction and persistent right middle lobe pneumonia. Fibrous histiocytomas are basically benign tumors of histiocytes and have been mistaken for other tumors such as fibroma, sclerosing hemangioma, neurilemoma, fibromatosis, hemangiopericytoma, fibrosarcoma, and some primitive sarcomas. Fibrous histiocytomas have not been reported in the trachea or bronchi. The patient was treated with endoscopic removal of the tumor, and has remained free of disease to this date.

Malignant fibrous histiocytomas in children

1984 ◽  
Vol 19 (1) ◽  
pp. 81-83 ◽  
Author(s):  
Tom Tracy ◽  
James P. Neifeld ◽  
Richard M. DeMay ◽  
Arnold M. Salzberg
Keyword(s):  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas

scholarly journals Retroperitoneal liposarcomas: Follow-up analysis of dedifferentiation after clinicopathologic reexamination of 86 liposarcomas and malignant fibrous histiocytomas

Cancer ◽  
2006 ◽  
Vol 106 (12) ◽  
pp. 2725-2733 ◽  
Author(s):  
Elizabeth Fabre-Guillevin ◽  
Jean-Michel Coindre ◽  
Nicolas de Saint Aubain Somerhausen ◽  
Francoise Bonichon ◽  
Eberhard Stoeckle ◽  
...  
Keyword(s):  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas

scholarly journals Clinical Features and Treatment of Fibrous Histiocytomas of the Tongue: A Systematic Review

2017 ◽  
Vol 22 (01) ◽  
pp. 094-102 ◽  
Author(s):  
Austin Nguyen ◽  
Adam Vaudreuil ◽  
Paul Haun ◽  
Gabriel Caponetti ◽  
Christopher Huerter
Keyword(s):  
Surgical Treatment ◽  
Clinical Presentation ◽  
Malignant Tumors ◽  
Case Reports ◽  
Data Synthesis ◽  
Excellent Outcome ◽  
Fibrous Histiocytomas ◽  
Pleomorphic Sarcoma ◽  
Level Data

Introduction Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Objectives This study systematically reviews the available literature discussing the clinical and pathological features of malignant and benign fibrous histiocytomas. Data Synthesis A total of 20 cases were included in this review. Patient-level data were extracted from cases to include clinical presentation, workup, treatment, and outcome. Conclusion Benign fibrous histiocytomas are consistent in clinical and histopathologic presentation. Surgical treatment provides excellent outcome, with no recurrence in all excised cases. Malignant tumors have a more aggressive clinical and pathological presentation. Surgical treatment with possible adjuvant radiotherapy resulted in recurrence in 40% of cases (follow-up of 24 months), and death due to disease in 47% of patients (follow-up of 19 months).

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