Angioimmunoblastic T-cell lymphoma with a clonal plasma cell proliferation that underwent immunoglobulin isotype switch in the skin, coinciding with cutaneous disease progression

2016 ◽  
Vol 43 (12) ◽  
pp. 1203-1210 ◽  
Author(s):  
Ana E. Suárez ◽  
M.J. Artiga ◽  
Carlos. Santonja ◽  
Santiago Montes-Moreno ◽  
P. De Pablo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Disease Progression ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Immunoglobulin Isotype ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Cutaneous Disease

scholarly journals The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Chunyan Wang ◽  
Xia Mao ◽  
Songya Liu ◽  
Cheng He ◽  
Ying Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Cell Lymphoma ◽  
Clinical Manifestations ◽  
Underlying Disease ◽  
T Cell Lymphoma ◽  
Diagnostic Dilemma ◽  
Angioimmunoblastic T Cell Lymphoma

Background. Angioimmunoblastic T cell lymphoma (AITL) is an aggressive Epstein–Barr virus-associated T cell lymphoma. Clinical syndromes of AITL are not confined to fever and lymphadenopathy, and patients may initially present with polyclonal plasma cell proliferation, which may obscure the underlying disease of AITL, delaying diagnosis. Case Presentation. Here, we report two AITL patients with excessive plasma cell proliferation in the bone marrow, peripheral blood, and ascites even mimicking plasma cell leukemia. Both of them had poor endings. Conclusions. Our report emphasizes the complexity of the clinical manifestations of AITL, which aims to increase the alertness of physicians and improve the rate of early diagnosis. Integrated diagnostic approaches such as histopathology, flow cytometry, cytogenetics, and molecular biology are essential for accurate diagnosis and precise therapy.

scholarly journals Silent T-cell receptor cutaneous T-cell lymphoma associated to a clonal plasma cell proliferation

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Caballero ◽  
Silvana Novelli ◽  
Anna Mozos ◽  
Pilar Garcia Muret ◽  
Anna Monter ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Gamma Delta ◽  
T Cell Lymphomas ◽  
Dismal Prognosis ◽  
Gamma Delta T Cell

Within T-cell lymphomas (TCL) there are 2 entities expressing gamma-delta TCR: hepatosplenic gamma-delta T-cell lymphoma (HSGDTL) and the primary cutaneous gamma-delta T-cell lymphoma (PCGDTL). PCGDTL is a rare form of Tcell lymphoma with specific tropism for skin that have a dismal prognosis. Although even rarer, there have been reports of TCL with loss of expression of the TCR, which have been termed peripheral TCL TCR-silent type. We report the case of a cutaneous TCR-silent type lymphoma associated to a clonal plasma cell proliferation with an ominous outcome that led to a lot of discussion in its classification. Due to the aggressiveness of the disease and the scant evidence about therapy in this strange entity the outcome was fatal. We report a unique case of a TCR-silent cutaneous TCL with an exceptional histopathology, prolonged clinical evolution and a subsequent plasma cell clonal expansion.

Immunoblastic Lymphadenopathy-Like T Cell Lymphoma Evolving into a Massive Plasma Cell Proliferation with Biclonal Paraproteinemia

1998 ◽  
Vol 100 (3) ◽  
pp. 151-155 ◽  
Author(s):  
Takakazu Higuchi ◽  
Jun-ichi Tada ◽  
Hiraku Mori ◽  
Haruo Niikura ◽  
Mitsuhiro Omine ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Immunoblastic Lymphadenopathy

scholarly journals Simultaneous Occurrence of Angioimmunoblastic T-cell Lymphoma and Plasma Cell Leukemia

2015 ◽  
Vol 35 (1) ◽  
pp. 149-151 ◽  
Author(s):  
Mi-Ae Jang ◽  
Seung-Tae Lee ◽  
Hee-Jin Kim ◽  
SeokJin Kim ◽  
Sun-Hee Kim
Keyword(s):  
T Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Leukemia ◽  
Simultaneous Occurrence ◽  
Cell Leukemia ◽  
Angioimmunoblastic T Cell Lymphoma

Unique evolution of angioimmunoblastic T cell lymphoma to Epstein-Barr virus–positive plasma cell myeloma

2020 ◽  
Vol 99 (12) ◽  
pp. 2949-2952
Author(s):  
Thomas S. Y. Chan ◽  
Alvin H. W. Ip ◽  
Rex Au-Yeung ◽  
Annie W. K. Pang ◽  
Yok-Lam Kwong
Keyword(s):  
T Cell ◽  
Plasma Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Myeloma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals A case of CD10-negative angioimmunoblastic T cell lymphoma with leukemic change and increased plasma cells mimicking plasma cell leukemia: A case report

2015 ◽  
Vol 10 (3) ◽  
pp. 1555-1560 ◽  
Author(s):  
YASUSHI ADACHI ◽  
TAKUYA HINO ◽  
MASAHIKO OHSAWA ◽  
KAZUHITO UEKI ◽  
TOMOKO MURAO ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Leukemia ◽  
Cell Leukemia ◽  
Angioimmunoblastic T Cell Lymphoma
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