scholarly journals A case of CD10-negative angioimmunoblastic T cell lymphoma with leukemic change and increased plasma cells mimicking plasma cell leukemia: A case report

2015 ◽  
Vol 10 (3) ◽  
pp. 1555-1560 ◽  
Author(s):  
YASUSHI ADACHI ◽  
TAKUYA HINO ◽  
MASAHIKO OHSAWA ◽  
KAZUHITO UEKI ◽  
TOMOKO MURAO ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Leukemia ◽  
Cell Leukemia ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals Simultaneous Occurrence of Angioimmunoblastic T-cell Lymphoma and Plasma Cell Leukemia

2015 ◽  
Vol 35 (1) ◽  
pp. 149-151 ◽  
Author(s):  
Mi-Ae Jang ◽  
Seung-Tae Lee ◽  
Hee-Jin Kim ◽  
SeokJin Kim ◽  
Sun-Hee Kim
Keyword(s):  
T Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Leukemia ◽  
Simultaneous Occurrence ◽  
Cell Leukemia ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Chunyan Wang ◽  
Xia Mao ◽  
Songya Liu ◽  
Cheng He ◽  
Ying Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Cell Lymphoma ◽  
Clinical Manifestations ◽  
Underlying Disease ◽  
T Cell Lymphoma ◽  
Diagnostic Dilemma ◽  
Angioimmunoblastic T Cell Lymphoma

Background. Angioimmunoblastic T cell lymphoma (AITL) is an aggressive Epstein–Barr virus-associated T cell lymphoma. Clinical syndromes of AITL are not confined to fever and lymphadenopathy, and patients may initially present with polyclonal plasma cell proliferation, which may obscure the underlying disease of AITL, delaying diagnosis. Case Presentation. Here, we report two AITL patients with excessive plasma cell proliferation in the bone marrow, peripheral blood, and ascites even mimicking plasma cell leukemia. Both of them had poor endings. Conclusions. Our report emphasizes the complexity of the clinical manifestations of AITL, which aims to increase the alertness of physicians and improve the rate of early diagnosis. Integrated diagnostic approaches such as histopathology, flow cytometry, cytogenetics, and molecular biology are essential for accurate diagnosis and precise therapy.

Rapid Fatal Acute Peripheral T-Cell Lymphoma Associated With IgG Plasma Cell Leukemia and IgA Hypergammaglobulinemia

2016 ◽  
Vol 24 (10) ◽  
pp. e89-e93 ◽  
Author(s):  
Nives Jonjić ◽  
Irena Seili Bekafigo ◽  
Dora Fučkar Čupić ◽  
Ksenija Lučin ◽  
Antica Duletić Načinović ◽  
...  
Keyword(s):  
T Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma

scholarly journals A strange lupus-like malar rash with renal involvement: an angioimmunoblastic T-cell lymphoma - A case report

2014 ◽  
Vol 3 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Andrea Dalbeni ◽  
Luca Gomarasca ◽  
Maria C. Bellocchi ◽  
Roberta Nuvolari ◽  
Matteo Bertagnin ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Lymphoma ◽  
Renal Involvement ◽  
T Cell Lymphoma ◽  
Malar Rash ◽  
Angioimmunoblastic T Cell Lymphoma

scholarly journals Angioimmunoblastic T‐cell lymphoma after acute myeloid leukemia: Alleged common pathogenesis. A case report and literature review

2020 ◽  
Vol 8 (12) ◽  
pp. 3494-3497
Author(s):  
Isabel Iturrate ◽  
Javier Loscertales ◽  
Elena Fernández‐Ruiz ◽  
Patricia Muñoz ◽  
Consuelo López ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
T Cell ◽  
Literature Review ◽  
Myeloid Leukemia ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Common Pathogenesis ◽  
Acute Myeloid

scholarly journals Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

Blood ◽  
2010 ◽  
Vol 115 (5) ◽  
pp. 1026-1036 ◽  
Author(s):  
Javeed Iqbal ◽  
Dennis D. Weisenburger ◽  
Timothy C. Greiner ◽  
Julie M. Vose ◽  
Timothy McKeithan ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
High Expression ◽  
Molecular Signature ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Adult T Cell Leukemia

Abstract Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK+) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL–not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK+ ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1–induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.

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