Phosphohistone-H3 and Ki-67 immunostaining in cutaneous pilar leiomyoma and leiomyosarcoma (atypical intradermal smooth muscle neoplasm)

2013 ◽  
Vol 40 (6) ◽  
pp. 557-563 ◽  
Author(s):  
Munir H Idriss ◽  
Viktoryia Kazlouskaya ◽  
Saurabh Malhotra ◽  
Christian Andres ◽  
Dirk M. Elston
Keyword(s):  
Smooth Muscle ◽  
Ki 67 ◽  
Smooth Muscle Neoplasm ◽  
Phosphohistone H3

Leiomyoma with Bizarre Nuclei (Symplastic Leiomyoma) in the Paratubal Cyst Wall: Report of a Rare Case

2021 ◽  
pp. 106689692199779
Author(s):  
Murat Celik
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Cyst Wall ◽  
Rare Case ◽  
Clinical Behavior ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Neoplasm ◽  
Histological Variants ◽  
Eosinophilic Cytoplasm ◽  
Paratubal Cyst

Leiomyoma is a benign mesenchymal tumor that develops from smooth muscle cells. It can present in various histological variants. Leiomyoma with bizarre nuclei is an infrequent variant of uterine smooth muscle neoplasm. It is characterized by focally or diffusely distributed bizarre cells on the background of a typical leiomyoma. These bizarre cells are large, multinucleated, or multilobulated and have an eosinophilic cytoplasm. Even though leiomyomas with bizarre nuclei display benign clinical behavior, their differential diagnosis from leiomyosarcoma can sometimes be difficult. Leiomyoma has been described most commonly in the uterus. There is no case of leiomyoma originating from paratubal cysts described in the literature. In this article, we present a rare case of leiomyoma with bizarre nuclei originating from a paratubal cyst.

Gastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass

2004 ◽  
Vol 128 (12) ◽  
pp. 1442-1444 ◽  
Author(s):  
Katherine M. Ceballos ◽  
Julie-Ann Francis ◽  
John L. Mazurka
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Gastrointestinal Stromal Tumor ◽  
Interstitial Cell ◽  
Smooth Muscle Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Neoplasms ◽  
Smooth Muscle Neoplasm ◽  
Rectal Involvement ◽  
Vaginal Smooth Muscle

Abstract Gastrointestinal stromal tumors are CD117 (c-Kit)–positive mesenchymal neoplasms with histologic and ultrastructural features of the interstitial cell of Cajal. While tumors outside of the gastrointestinal tract have been described, to our knowledge the case we present is the first such case in the vagina. We describe a 75-year-old woman with a recurrent vaginal gastrointestinal stromal tumor without apparent rectal involvement. This tumor was characterized by short intersecting fascicles of spindled cells, focal necrosis, and 12 to 15 mitoses per 50 high-power fields. Immunohistochemistry revealed diffuse cytoplasmic positivity for CD117 (c-Kit), CD34, vimentin, and h-caldesmon. Tumor cells were negative for S100, desmin, actin, and CAM 5.2. The differential diagnosis in this case included a vaginal smooth muscle tumor. While histologically similar to a smooth muscle neoplasm, the immunohistochemical profile ruled out smooth muscle differentiation. Gastrointestinal stromal tumor should be considered in the differential diagnosis of vaginal mesenchymal neoplasms.

scholarly journals MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3

2017 ◽  
Vol 43 (1) ◽  
pp. 282-292 ◽  
Author(s):  
Ying Xu ◽  
Yihua Bei ◽  
Shutong Shen ◽  
Jialiang Zhang ◽  
Yichao Lu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Western Blot ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Target Genes ◽  
Cell Number ◽  
Pulmonary Artery Hypertension ◽  
Luciferase Assay ◽  
Ki 67

Background/Aims: Aberrant vascular smooth muscle cell (VSMC) proliferation plays an important role in the development of pulmonary artery hypertension (PAH). Dysregulated microRNAs (miRNAs, miRs) have been implicated in the progression of PAH. miR-222 has a pro-proliferation effect on VSMCs while it has an anti-proliferation effect on vascular endothelial cells (ECs). As the biological function of a single miRNA could be cell-type specific, the role of miR-222 in pulmonary artery smooth muscle cell (PASMC) proliferation is not clear and deserves to be explored. Methods: PASMCs were transfected with miR-222 mimic or inhibitor and PASMC proliferation was determined by Western blot for PCNA, Ki-67 and EdU staining, and cell number counting. The target genes of miR-222 including P27 and TIMP3 were determined by luciferase assay and Western blot. In addition, the functional rescue experiments were performed based on miR-222 inhibitor and siRNAs to target genes. Results: miR-222 mimic promoted PASMC proliferation while miR-222 inhibitor decreased that. TIMP3 was identified to be a direct target gene of miR-222 based on luciferase assay. Meanwhile, P27 and TIMP3 were up-regulated by miR-222 inhibitor and down-regulated by miR-222 mimic. Moreover, P27 siRNA and TIMP3 siRNA could both attenuate the anti-proliferation effect of miR-222 inhibitor in PASMCs, supporting that P27 and TIMP3 are at least partially responsible for the regulatory effect of miR-222 in PASMCs. Conclusion: miR-222 promotes PASMC proliferation at least partially through targeting P27 and TIMP3.

The Origin of the Pseudoglandular Spaces in Metastatic Smooth Muscle Neoplasm of Uterine Origin

CHEST Journal ◽  
1983 ◽  
Vol 83 (2) ◽  
pp. 270-274 ◽  
Author(s):  
Guillermo A. Herrera ◽  
Philip A. Miles ◽  
Harvey Greenberg ◽  
Bernhard E.F. Reimann ◽  
Idelle M. Weisman
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Neoplasm

scholarly journals Multiple Smooth-Muscle Neoplasm and Thyroid Carcinoma in An Adult With AIDS

1998 ◽  
Vol 37 (2) ◽  
pp. 205-208
Author(s):  
Xuefeng Jing ◽  
Yasushi Nakamura ◽  
Misa Nakamura ◽  
Liang Shan ◽  
Toyoharu Yokoi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Thyroid Carcinoma ◽  
Smooth Muscle Neoplasm

scholarly journals An estrogen receptor-positive locally aggressive smooth muscle neoplasm of the transverse colon

Medicine ◽  
2018 ◽  
Vol 97 (46) ◽  
pp. e13250
Author(s):  
Genki Usui ◽  
Hirotsugu Hashimoto ◽  
Kazuteru Watanabe ◽  
Yoshiya Sugiura ◽  
Masashi Kusakabe ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Smooth Muscle ◽  
Transverse Colon ◽  
Smooth Muscle Neoplasm ◽  
Estrogen Receptor Positive
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