A quantitative immunohistochemical study of the expression of mesangial α-smooth muscle actin and the proliferation marker Ki-67 in glomerulonephritis in man

1997 ◽  
Vol 431 (5) ◽  
pp. 345-350 ◽  
Author(s):  
V. Groma ◽  
N. Marcussen ◽  
S. Olsen
Keyword(s):  
Smooth Muscle ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Proliferation Marker ◽  
Muscle Actin ◽  
Ki 67

scholarly journals Occurrence of an Abdominal Leiomyosarcoma in the Cyprinus carpio: Optical and Immunohistochemical Study

2021 ◽  
pp. 10-19
Author(s):  
Luis Alberto Romano ◽  
Virgínia Fonseca Pedrosa
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Immunohistochemical Study ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Swim Bladder ◽  
Muscle Actin ◽  
Immunohistochemical Examination ◽  
Vortex Pattern ◽  
Spindle Cells

A capsulated nodular neoplasm measuring 9 cm in diameter, located between the swim bladder and the kidney sample of Cyprinuscarpio, was in laboratory. The neoplasm had a solid consistency in one sector and very adherent to the capsule. Histopathological examination of the neoplasm revealed a monotonous proliferation of spindle cells, and pleomorphic, sometimes in a vortex pattern and interspersed with collagen fibers. Cells had numerous well-oriented myofibrils giving them a deep red. The cytoplasm is eosinophilic and the nuclei are hyperchromatic located in the center with blunt or "cigar-shaped" ends. In the immunohistochemical examination, the tumor cells were positive for desmin, smooth muscle actin and K-47, the latter antibody showing significant cell proliferation. Due to histopathological and immunohistochemical findings, diagnosis was made with leiomyosarcoma.

Stromal Expression of CD34, α-Smooth Muscle Actin and CD26/DPPIV in Squamous Cell Carcinoma of the Skin: A Comparative Immunohistochemical Study

2011 ◽  
Vol 18 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Ayper Kacar ◽  
Ata Türker Arikok ◽  
Tuba Dilay Kokenek Unal ◽  
Evrim Onder ◽  
Sema Hucumenoglu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Muscle Actin

scholarly journals Inflammatory fibroid polyp: an immunohistochemical study

2004 ◽  
Vol 41 (2) ◽  
pp. 104-107 ◽  
Author(s):  
Gilda da Cunha Santos ◽  
Venâncio A.F. Alves ◽  
Alda Wakamatsu ◽  
Sérgio Zucoloto
Keyword(s):  
Smooth Muscle ◽  
Factor Viii ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Positive Staining ◽  
Muscle Actin ◽  
Inflammatory Fibroid Polyp ◽  
Spindle Cells ◽  
S 100 ◽  
Fibroid Polyp

BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.

Sign in / Sign up

Export Citation Format

Share Document