scholarly journals Type‐2 airway inflammation in mild asthma patients with high blood eosinophils and high fractional exhaled nitric oxide

2021 ◽  
Author(s):  
Thomas Southworth ◽  
Marleen Van Geest ◽  
Dave Singh
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Mild Asthma ◽  
Fractional Exhaled Nitric Oxide ◽  
Asthma Patients ◽  
Blood Eosinophils

scholarly journals Airway inflammation phenotype prediction in asthma patients using lung sound analysis with fractional exhaled nitric oxide

2017 ◽  
Vol 66 (4) ◽  
pp. 581-585 ◽  
Author(s):  
Terufumi Shimoda ◽  
Yasushi Obase ◽  
Yukio Nagasaka ◽  
Hiroshi Nakano ◽  
Reiko Kishikawa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Lung Sound ◽  
Fractional Exhaled Nitric Oxide ◽  
Phenotype Prediction ◽  
Sound Analysis ◽  
Asthma Patients

The Utility of Serum IL-1β and CRP Together with Fractional Exhaled Nitric Oxide in the Diagnosis of Asthma in Adults

2021 ◽  
Vol 19 (8) ◽  
pp. 119-124
Author(s):  
Hayder Abdul-Amir Makki Al-Hindy ◽  
Ali Jihad Hemid Al-Athari ◽  
Mazin J. Mousa ◽  
Safa Jihad Hameed ◽  
Suhad Hafidh Obeed
Keyword(s):  
Nitric Oxide ◽  
Sensitivity And Specificity ◽  
Bronchial Asthma ◽  
High Sensitivity ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Asthmatic Patients ◽  
Significant Difference ◽  
Asthma Patients ◽  
Hs Crp

Background: Bronchial asthma (BrA), recognized lately as an umbrella, covers various subtypes rather than only one disease. Asthma is a chronic inflammation of the airways, in which cytokines could play a crucial role in its pathogenesis. Hence, labors to progress noninvasive markers for asthma had centered through this era. Presently, the fractional exhaled nitric oxide (FeNO), serum C-reactive protein (CRP), and interleukin levels are emerging analytical biomarkers in this field. FeNO is a noninvasive and practical tool even in mild asthma. This study aimed to evaluate the utility of serum IL-1β and CRP together with fractional exhaled nitric oxide in the diagnosis of adult bronchial asthma. Method: The study was a case control, including 150-patients and 100-healthy controls. FeNO tests, measurements of plasma levels IL-1β and HS-CRP had undertaken for all the participants. The statistical data had examined by SPSS (V/27) for Windows. Descriptive data of the variables had compatibly used. A significance lower than or identical to 0.05 had intended. ROC curve examination of FeNO tests, IL-1β, and HS-CRP, to predict asthma from healthy control had applied. Results: there was a significant difference in the FeNo test, HS-CRP levels, and BMI, while no significant difference in all other variables between the groups. The FeNo results correlate positively, though not significantly, with the levels of IL-1β in asthmatic patients (> 0.05). There was a nonsignificant negative correlation between the FeNo results with the level of HSCRP. The accuracy, sensitivity, and specificity of the IL-1β to distinguish asthma were 68.6% and 58% at 95% CI [0.41-0.745], respectively, which was not significant (p>0.05). However, ROC analysis of HS-CRP revealed predictability for asthma patients (p-0.000), with higher accuracy, sensitivity, and specificity: 89.9%, and 68.1% at 95% CI [0.820-0.979], respectively. The FeNo tests revealed highly significant (0.000), high sensitivity, and specific (91% for both) with high 95% CI [0.938-1.000] predictability for asthma. Conclusion: The utility of circulating HS-CRP is more valuable than IL-1β when combined with fractional exhaled nitric oxide in the diagnosis of asthma. Novel biomarkers could improve the precision of this field.

scholarly journals Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap

2018 ◽  
Vol Volume 13 ◽  
pp. 2525-2532 ◽  
Author(s):  
Yusuke Takayama ◽  
Hiroshi Ohnishi ◽  
Fumiya Ogasawara ◽  
Kosuke Oyama ◽  
Tetsuya Kubota ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Clinical Utility ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Blood Eosinophils

scholarly journals The association between serum apolipoprotein B and fractional exhaled nitric oxide in bronchial asthma patients

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Jung Won Heo ◽  
Hwa Young Lee ◽  
Solji Han ◽  
Hye Seon Kang ◽  
Soon Seog Kwon ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bronchial Asthma ◽  
Apolipoprotein B ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Asthma Patients

Off-Line Fractional Exhaled Nitric Oxide Measurement Is Useful to Screen Allergic Airway Inflammation in an Adult Population

2007 ◽  
Vol 44 (10) ◽  
pp. 805-810 ◽  
Author(s):  
Junpei Saito ◽  
Suguru Sato ◽  
Hideki Hasunuma ◽  
Yasushi Ishimaru ◽  
Hiroshi Kanegae ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Adult Population ◽  
Allergic Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

High fractional exhaled nitric oxide levels in asthma patients: Does size matter?

2021 ◽  
Author(s):  
Nir Diamant ◽  
Israel Amirav ◽  
Keren Armoni‐Domany ◽  
Efraim Sadot ◽  
Udi Shapira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Asthma Patients ◽  
Size Matter

scholarly journals Trigger of Bronchial Hyperresponsiveness Development may not always need Eosinophilic Airway Inflammation in Very Early Stage of Asthma

2016 ◽  
Vol 7 (1) ◽  
pp. ar.2016.7.0145 ◽  
Author(s):  
Yasushi Obase ◽  
Terufumi Shimoda ◽  
Reiko Kishikawa ◽  
Shigeru Kohno ◽  
Tomoaki Iwanaga
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Vital Capacity ◽  
Bronchial Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Flow Volume ◽  
Impulse Oscillometry ◽  
Eosinophilic Inflammation ◽  
Fractional Exhaled Nitric Oxide ◽  
Sputum Eosinophils

Background Cough variant asthma (CVA), a suggested precursor of standard bronchial asthma (SBA), is characterized by positive bronchial hyperresponsiveness (BHR) and a chronic cough response to bronchodilator that persists for >8 weeks. Objective Airway inflammation, BHR, and airway obstructive damage were analyzed to assess whether CVA represents early or mild-stage SBA. Methods Patients with newly diagnosed CVA (n = 72) and SBA (n = 84) naive to oral or inhaled corticosteroids and without exacerbated asthma were subjected to spirometry, impulse oscillometry, BHR tests, sputum induction, and fractional exhaled nitric oxide measurements. Results In the patients with CVA, spirometry demonstrated higher forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio, FEV1 percent predicted, flow volume at 50% of vital capacity % predicted, and flow volume at 25% of vital capacity % predicted values, and impulse oscillometry demonstrated lower R5–Z20, AX, and Fres, and higher X5 values. In addition, the fractional exhaled nitric oxide and sputum eosinophil numbers were lower and the PC20 was higher than in patients with moderate SBA. However, these factors were similar in the patients with CVA and in the patients with intermittent mild SBA. A significantly smaller proportion of the patients with CVA had increased sputum eosinophils than the patients with intermittent mild SBA (p < 0.0001). However, interestingly, among the patients with CVA, no significant differences in the PC20 values were found between the patients with and those without increased sputum eosinophils. Conclusions All measures of central and peripheral airway obstruction, eosinophilic inflammation, and airway hyperresponsiveness in patients with CVA were milder than in patients with moderate SBA but were similar to those of patients with intermittent mild SBA. In CVA, the BHR was not affected by airway eosinophilic inflammation, which indicated that the very early development of BHR may not always need airway eosinophilic inflammation.

Sign in / Sign up

Export Citation Format

Share Document