scholarly journals Study of the correlations between fractional exhaled nitric oxide in exhaled breath and atopic status, blood eosinophils, FCER2 mutation, and asthma control in Vietnamese children

2016 ◽  
Vol Volume 9 ◽  
pp. 163-170 ◽  
Author(s):  
Sy Duong-Quy ◽  
Hanh Nguyen Thi Bich ◽  
Huong Duong Thi Ly ◽  
Thom Vu Thi ◽  
Nhung Pham Thi Hong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Asthma Control ◽  
Exhaled Nitric Oxide ◽  
Exhaled Breath ◽  
Fractional Exhaled Nitric Oxide ◽  
Atopic Status ◽  
Blood Eosinophils

scholarly journals Association of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic children

2015 ◽  
Vol 109 (5) ◽  
pp. 572-579 ◽  
Author(s):  
Sohyoung Yang ◽  
Joohyun Park ◽  
Youn Kyung Lee ◽  
Heon Kim ◽  
Youn-Soo Hahn
Keyword(s):  
Nitric Oxide ◽  
Asthma Control ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

scholarly journals Clinical and Economic Consequences of Switching From Omalizumab to Mepolizumab in Uncontrolled Severe Eosinophilic Asthma: an Observational Retrospective Study

2020 ◽  
Author(s):  
Giovanna Elisiana Carpagnano ◽  
Emanuela Resta ◽  
Massimiliano Povero ◽  
Corrado Pelaia ◽  
Mariella D'Amato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Asthma Control ◽  
Exhaled Nitric Oxide ◽  
Blood Eosinophil ◽  
Fractional Exhaled Nitric Oxide ◽  
Eosinophilic Asthma ◽  
Exacerbation Rate ◽  
Serum Ige ◽  
Severe Eosinophilic Asthma ◽  
Oral Corticosteroids

Abstract Background: Severe asthma is burdened by frequent exacerbations and use of oral corticosteroids, which worsen patients’ health and increase healthcare spending. The aim of this study was to assess the clinical and economic impact of switching from omalizumab to mepolizumab in patients eligible for both biologics, but not optimally controlled by omalizumab.Methods: We retrospectively enrolled uncontrolled severe asthmatic patients, referred to seven asthma clinics in Italy, who switched from omalizumab to mepolizumab during the last two years. Clinical, functional, and laboratory information included blood eosinophil count, asthma control test, spirometry, serum IgE, fractional exhaled nitric oxide, oral corticosteroids intake, use of controller and rescue drugs, exacerbations/hospitalizations, visits and diagnostic exams. Within the perspective of Italian National Health System, a pre- and post-mepolizumab 12-month standardized total cost per patient was calculated.Results: 33 patients were enrolled: 5 males and 28 females, mean age 57 years, mean disease onset 24 years. At omalizumab discontinuation, 88% were oral corticosteroids-dependent with annual mean rate of 4.0 clinically significant exacerbations, 0.30 exacerbations needing emergency room visits or hospitalization; absenteeism due to disease was 10.4 days per patient. Switch to mepolizumab improved all clinical outcomes, reducing total exacerbation rate (RR = 0.06, 95% CI 0.03 to 0.14), oral corticosteroids -dependent patients (OR = 0.02, 95% CI 0.005 to 0.08), and the number of lost working days because of uncontrolled disease (Δ = -7.9, 95% CI -11.2 to -4.6). Pulmonary function improved, as well as serum IgE, fractional exhaled nitric oxide and eosinophils decreased. Mean annual costs were € 12,239 for omalizumab and € 12,639 for mepolizumab (Δ = € 400, 95% CI -1,588 to 2,389); the increment due to drug therapy (+ € 1,581) was almost offset by savings regarding all other cost items (- € 1,181). Conclusions: Patients with severe eosinophilic asthma, not controlled by omalizumab, experienced comprehensive benefits in asthma control by switching to mepolizumab. These relevant improvements were burdened by only very slight increases in economic costs.

scholarly journals Levels of Exhaled Breath Condensate pH and Fractional Exhaled Nitric Oxide in Retired Coal Miners

2010 ◽  
Vol 26 (4) ◽  
pp. 329-337 ◽  
Author(s):  
Jong-Seong Lee ◽  
Jae-Hoon Shin ◽  
Joung-Oh Lee ◽  
Kyung-Myung Lee ◽  
Ji-Hong Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Breath Condensate ◽  
Exhaled Nitric Oxide ◽  
Exhaled Breath ◽  
Fractional Exhaled Nitric Oxide ◽  
Coal Miners ◽  
Breath Condensate

scholarly journals Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap

2018 ◽  
Vol Volume 13 ◽  
pp. 2525-2532 ◽  
Author(s):  
Yusuke Takayama ◽  
Hiroshi Ohnishi ◽  
Fumiya Ogasawara ◽  
Kosuke Oyama ◽  
Tetsuya Kubota ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Clinical Utility ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Blood Eosinophils
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