scholarly journals Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

2021 ◽  
Author(s):  
Kosuke Yoshida ◽  
Yuki Doi ◽  
Norihiko Iwazaki ◽  
Hidenori Yasuhara ◽  
Yuka Ikenaga ◽  
...  
Keyword(s):  
Pharmacokinetic Data ◽  
Human Pharmacokinetics ◽  
Chimeric Mice

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

Xenobiotica ◽  
2017 ◽  
Vol 47 (12) ◽  
pp. 1052-1063 ◽  
Author(s):  
Maki Miyamoto ◽  
Shinji Iwasaki ◽  
Ikumi Chisaki ◽  
Sayaka Nakagawa ◽  
Nobuyuki Amano ◽  
...  
Keyword(s):  
Human Pharmacokinetics ◽  
Chimeric Mice

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Xenobiotica ◽  
2019 ◽  
Vol 49 (12) ◽  
pp. 1379-1387 ◽  
Author(s):  
Maki Miyamoto ◽  
Shinji Iwasaki ◽  
Ikumi Chisaki ◽  
Sayaka Nakagawa ◽  
Nobuyuki Amano ◽  
...  
Keyword(s):  
Half Life ◽  
Human Pharmacokinetics ◽  
Chimeric Mice

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

Xenobiotica ◽  
2018 ◽  
Vol 49 (4) ◽  
pp. 404-414 ◽  
Author(s):  
Keigo Nakayama ◽  
Soichiro Ito ◽  
Masahiro Suzuki ◽  
Hiroaki Takubo ◽  
Hiroshi Yamazaki ◽  
...  
Keyword(s):  
Human Pharmacokinetics ◽  
Chimeric Mice ◽  
Physiologically Based

Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

Xenobiotica ◽  
2019 ◽  
Vol 49 (11) ◽  
pp. 1311-1322
Author(s):  
Hiroshi Iwata ◽  
Masatomo Goto ◽  
Norifumi Sakai ◽  
Hiroshi Suemizu ◽  
Hiroshi Yamazaki
Keyword(s):  
Human Pharmacokinetics ◽  
Chimeric Mice ◽  
Diisononyl Phthalate
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