Temporal trends and current use of de‐novo belatacept in kidney transplant recipients in the United States

2021 ◽  
Author(s):  
Geeta Karadkhele ◽  
Charlotte Duneton ◽  
Rouba Garro ◽  
Idelberto Raul Badell ◽  
Thomas C. Pearson ◽  
...  
Keyword(s):  
United States ◽  
Kidney Transplant ◽  
De Novo ◽  
Temporal Trends ◽  
The United States ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

The Epidemiologic Burden of Tacrolimus Variability among Kidney Transplant Recipients in the United States

2019 ◽  
Vol 50 (5) ◽  
pp. 370-374 ◽  
Author(s):  
Pratik B. Shah ◽  
Jennifer L. Ennis ◽  
Patrick N. Cunningham ◽  
Michelle A. Josephson ◽  
Rita L. McGill
Keyword(s):  
United States ◽  
Linear Regression ◽  
Kidney Transplant ◽  
De Novo ◽  
The United States ◽  
National Sample ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Data Set ◽  
Tacrolimus Level

Background: Within-patient tacrolimus level variability >30% has been shown to be a risk factor for de novo donor-specific antibody formation and death-censored graft failure among kidney transplant recipients. The burden of tacrolimus variability and the correlation between variability and subtherapeutic tacrolimus levels were examined in a large national data set. Methods: All tacrolimus levels drawn at LabCorp® facilities in the United States with a diagnosis code for kidney transplant between November 2011 and September 2017 were examined, excluding values that could represent new allografts. Tacrolimus variability was calculated if at least 3 levels were available. The percentage of subtherapeutic (<4.0 ng/dL) tacrolimus levels (%subT) was also calculated. Interdependence between %subT and tacrolimus variability was assessed with correlation analysis and linear regression. Results: There were 410,257 tacrolimus levels among 27,375 patients, who had 11 (interquartile range [IQR] 6–20) tacrolimus levels over a median follow-up of 26.5 (IQR 12.8–46.1) months. Median tacrolimus variability was 30.6%, and 51.6% of patients exceeded 30% variability. Median %subT was 11.1% (IQR 0–30.8%), and 34.3% of patients had no subtherapeutic levels. The correlation coefficient between tacrolimus variability and %subT was 0.253 (p< 0.001). In linear regression, tacrolimus variability increased 1.86% for each 10% increase in %subT (p < 0.001), but R-squared for this model was only 0.06. Conclusion: More than half of established kidney transplant patients from a large national sample exhibited levels of tacrolimus variability that have been associated with inferior transplant outcomes. Tacrolimus variability has a weak association with subtherapeutic levels, but represents a more complicated constellation of clinical factors.

Metformin Use in Kidney Transplant Recipients Throughout the United States.

2014 ◽  
Vol 98 ◽  
pp. 525
Author(s):  
J. Stephen ◽  
T. Anderson-Haag ◽  
S. Gustafson ◽  
J. Snyder ◽  
A. Israni ◽  
...  
Keyword(s):  
United States ◽  
Kidney Transplant ◽  
The United States ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Metformin Use in Kidney Transplant Recipients in the United States: An Observational Study

2014 ◽  
Vol 40 (6) ◽  
pp. 546-553 ◽  
Author(s):  
Jenise Stephen ◽  
Teresa L. Anderson-Haag ◽  
Sally Gustafson ◽  
Jon J. Snyder ◽  
Bertram L. Kasiske ◽  
...  
Keyword(s):  
United States ◽  
Observational Study ◽  
Kidney Transplant ◽  
The United States ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Trends in the Causes of Death among Kidney Transplant Recipients in the United States (1996–2014)

2018 ◽  
Vol 48 (6) ◽  
pp. 472-481 ◽  
Author(s):  
Ahmed A. Awan ◽  
Jingbo Niu ◽  
Jenny S. Pan ◽  
Kevin F. Erickson ◽  
Sreedhar Mandayam ◽  
...  
Keyword(s):  
United States ◽  
Kidney Transplant ◽  
Cardiovascular Mortality ◽  
Causes Of Death ◽  
Graft Loss ◽  
Graft Function ◽  
The United States ◽  
Mortality Data ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Background: Death with graft function remains an important cause of graft loss among kidney transplant recipients (KTRs). Little is known about the trend of specific causes of death in KTRs in recent years. Methods: We analyzed United States Renal Data System data (1996–2014) to determine 1- and 10-year all-cause and cause-specific mortality in adult KTRs who died with a functioning allograft. We also studied 1- and 10-year trends in the various causes of mortality. Results: Of 210,327 KTRs who received their first kidney transplant from 1996 to 2014, 3.2% died within 1 year after transplant. Cardiovascular deaths constituted the majority (24.7%), followed by infectious (15.2%) and malignant (2.9%) causes; 40.1% of deaths had no reported cause. Using 1996 as the referent year, all-cause as well as cardiovascular mortality declined, whereas mortality due to malignancy did not. For analyses of 10-year mortality, we studied 94,384 patients who received a first kidney transplant from 1996 to 2005. Of those, 22.1% died over 10 years and the causative patterns of their causes of death were similar to those associated with 1-year mortality. Conclusions: Despite the downtrend in mortality over the last 2 decades, a significant percentage of KTRs die in 10-years with a functioning graft, and cardiovascular mortality remains the leading cause of death. These data also highlight the need for diligent collection of mortality data in KTRs.

Clinical Management of Kidney Transplant Recipients

2019 ◽  
pp. 457-459
Author(s):  
James A. Onigkeit
Keyword(s):  
United States ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Clinical Management ◽  
Living Donor ◽  
Kidney Transplant Recipient ◽  
Deceased Donor ◽  
The United States ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Kidney transplant is common. More than 19,000 kidney transplants were performed in the United States in 2017. About two-thirds were deceased donor transplants, and about one-third were living donor transplants. The clinical management of a kidney transplant recipient begins in the operating room. Posttransplant complications can be divided into 2 categories: surgical and medical.

scholarly journals Emergency department use among kidney transplant recipients in the United States

2017 ◽  
Vol 18 (4) ◽  
pp. 868-880 ◽  
Author(s):  
Brendan P. Lovasik ◽  
Rebecca Zhang ◽  
Jason M. Hockenberry ◽  
Justin D. Schrager ◽  
Stephen O. Pastan ◽  
...  
Keyword(s):  
United States ◽  
Emergency Department ◽  
Kidney Transplant ◽  
The United States ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Emergency Department Use
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