scholarly journals Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost

2020 ◽  
Vol 34 (11) ◽  
Author(s):  
Siavash Raigani ◽  
Reinier J. De Vries ◽  
Cailah Carroll ◽  
Ya‐Wen Chen ◽  
David C. Chang ◽  
...  
Keyword(s):  
Organ Shortage ◽  
Machine Perfusion ◽  
Viability Testing ◽  
Normothermic Machine Perfusion ◽  
The Cost

scholarly journals SALVAGING DISCARDED LIVERS WITH NORMOTHERMIC MACHINE PERFUSION: IS IT WORTH THE COST?

2020 ◽  
Vol 104 (S3) ◽  
pp. S265-S265
Author(s):  
Reinier de Vries ◽  
Siavash Raigani ◽  
Cailah Carroll ◽  
Ya-Wen Chen ◽  
David C. Chang ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Normothermic Machine Perfusion ◽  
The Cost

scholarly journals Transplantation of discarded livers following viability testing with normothermic machine perfusion

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hynek Mergental ◽  
Richard W. Laing ◽  
Amanda J. Kirkham ◽  
M. Thamara P. R. Perera ◽  
Yuri L. Boteon ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Viability Testing ◽  
Normothermic Machine Perfusion

scholarly journals Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion

Metabolites ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 246 ◽  
Author(s):  
Negin Karimian ◽  
Siavash Raigani ◽  
Viola Huang ◽  
Sonal Nagpal ◽  
Ehab O. A. Hafiz ◽  
...  
Keyword(s):  
Energy Charge ◽  
Redox Status ◽  
High Energy ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Normothermic Perfusion ◽  
Normothermic Machine Perfusion ◽  
Anti Oxidant ◽  
Human Livers ◽  
The Cost

There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits. We examined the metabolomic profiles of discarded steatotic human livers during three hours of subnormothermic or normothermic machine perfusion. Steatotic livers regenerate higher stores of ATP during SNMP than NMP. However, there is a significant depletion of available glutathione during SNMP, likely due to an inability to overcome the high energy threshold needed to synthesize glutathione. This highlights the increased oxidative stress apparent in steatotic livers. Rescue of discarded steatotic livers with machine perfusion may require the optimization of redox status through repletion or supplementation of reducing agents.

scholarly journals Ex-Vivo Pharmacological Defatting of the Liver: A Review

2021 ◽  
Vol 10 (6) ◽  
pp. 1253
Author(s):  
Claire Goumard ◽  
Célia Turco ◽  
Mehdi Sakka ◽  
Lynda Aoudjehane ◽  
Philippe Lesnik ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Ex Situ ◽  
Special Focus ◽  
Organ Shortage ◽  
Machine Perfusion ◽  
Pharmacological Agents ◽  
Promising Tool ◽  
Normothermic Machine Perfusion ◽  
C Metabolism ◽  
Liver Machine Perfusion

The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model.

scholarly journals Hyperspectral Imaging and Machine Perfusion in Solid Organ Transplantation: Clinical Potentials of Combining Two Novel Technologies

2021 ◽  
Vol 10 (17) ◽  
pp. 3838
Author(s):  
Margot Fodor ◽  
Julia Hofmann ◽  
Lukas Lanser ◽  
Giorgi Otarashvili ◽  
Marlene Pühringer ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Hyperspectral Imaging ◽  
Survival Rates ◽  
Solid Organ Transplantation ◽  
Organ Shortage ◽  
Solid Organ ◽  
Machine Perfusion ◽  
Novel Technologies ◽  
Normothermic Machine Perfusion ◽  
Reduction Of Mortality

Organ transplantation survival rates have continued to improve over the last decades, mostly due to reduction of mortality early after transplantation. The advancement of the field is facilitating a liberalization of the access to organ transplantation with more patients with higher risk profile being added to the waiting list. At the same time, the persisting organ shortage fosters strategies to rescue organs of marginal donors. In this regard, hypothermic and normothermic machine perfusion are recognized as one of the most important developments in the modern era. Owing to these developments, novel non-invasive tools for the assessment of organ quality are on the horizon. Hyperspectral imaging represents a potentially suitable method capable of evaluating tissue morphology and organ perfusion prior to transplantation. Considering the changing environment, we here discuss the hypothetical combination of organ machine perfusion and hyperspectral imaging as a prospective feasibility concept in organ transplantation.

scholarly journals Human liver stem cell‐derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia

2021 ◽  
Vol 34 (9) ◽  
pp. 1607-1617
Author(s):  
Nicola De Stefano ◽  
Victor Navarro‐Tableros ◽  
Dorotea Roggio ◽  
Alberto Calleri ◽  
Federica Rigo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Extracellular Vesicles ◽  
Human Liver ◽  
Warm Ischemia ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion ◽  
Rat Livers

scholarly journals Point‐of‐Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model

2021 ◽  
Author(s):  
Samuel J. Kesseli ◽  
Jared N. Gloria ◽  
Nader Abraham ◽  
Samantha E. Halpern ◽  
Greta N. Cywinska ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Point Of Care ◽  
Machine Perfusion ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Care Assessment ◽  
Normothermic Machine Perfusion

scholarly journals Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration

Hepatology ◽  
2019 ◽  
Vol 70 (2) ◽  
pp. 682-695 ◽  
Author(s):  
Wayel Jassem ◽  
Emmanuel Xystrakis ◽  
Yasmeen G. Ghnewa ◽  
Muhammed Yuksel ◽  
Oltin Pop ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Proinflammatory Responses ◽  
Normothermic Machine Perfusion
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