Routine prophylaxis with proton pump inhibitors and post-transplant complications in kidney transplant recipients undergoing early corticosteroid withdrawal

2016 ◽  
Vol 30 (6) ◽  
pp. 694-702 ◽  
Author(s):  
Alesa Y. Courson ◽  
John R. Lee ◽  
Meredith J. Aull ◽  
Jennifer H. Lee ◽  
Sandip Kapur ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Corticosteroid Withdrawal ◽  
Routine Prophylaxis ◽  
Transplant Complications

scholarly journals Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis

2019 ◽  
Vol 9 (2) ◽  
pp. 35-47 ◽  
Author(s):  
Boonphiphop Boonpheng ◽  
Charat Thongprayoon ◽  
Tarun Bathini ◽  
Konika Sharma ◽  
Michael A Mao ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Concomitant Proton Pump Inhibitors With Mycophenolate Mofetil and the Risk of Rejection in Kidney Transplant Recipients

2014 ◽  
Vol 97 (5) ◽  
pp. 518-524 ◽  
Author(s):  
John P. Knorr ◽  
Mariel Sjeime ◽  
Leonard E. Braitman ◽  
Pankaj Jawa ◽  
Radi Zaki ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals MP805EFFECTS OF PROTON PUMP INHIBITORS ON KIDNEY TRANSPLANT RECIPIENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii730-iii730 ◽  
Author(s):  
Omer Uludag ◽  
Safak Mirioglu ◽  
Ahmet Dirim ◽  
Omer Akardere ◽  
Arif Akyildiz ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients

2019 ◽  
Vol 8 (12) ◽  
pp. 2162 ◽  
Author(s):  
Rianne M. Douwes ◽  
António W. Gomes-Neto ◽  
Joëlle C. Schutten ◽  
Else van den Berg ◽  
Martin H. de Borst ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Lower Plasma ◽  
Food And Nutrition ◽  
Magnesium Status ◽  
Magnesium Excretion ◽  
Plasma Magnesium

Proton-pump inhibitors (PPIs) are commonly used after kidney transplantation and there is rarely an incentive to discontinue treatment. In the general population, PPI use has been associated with hypomagnesaemia. We aimed to investigate whether PPI use is associated with plasma magnesium, 24-h urinary magnesium excretion and hypomagnesaemia, in kidney transplant recipients (KTR). Plasma magnesium and 24-h urinary magnesium excretion were measured in 686 stable outpatient KTR with a functioning allograft for ≥1 year from the TransplantLines Food and Nutrition Biobank and Cohort-Study (NCT02811835). PPIs were used by 389 KTR (56.6%). In multivariable linear regression analyses, PPI use was associated with lower plasma magnesium (β: −0.02, P = 0.02) and lower 24-h urinary magnesium excretion (β: −0.82, P < 0.001). Moreover, PPI users had a higher risk of hypomagnesaemia (plasma magnesium <0.70 mmol/L), compared with non-users (Odds Ratio (OR): 2.12; 95% confidence interval (CI) 1.43–3.15, P < 0.001). This risk tended to be highest among KTR taking high PPI dosages (>20 mg omeprazole Eq/day) and was independent of adjustment for potential confounders (OR: 2.46; 95% CI 1.32–4.57, P < 0.005). No interaction was observed between PPI use and the use of loop diuretics, thiazide diuretics, tacrolimus, or diabetes (Pinteraction > 0.05). These results demonstrate that PPI use is independently associated with lower magnesium status and hypomagnesaemia in KTR. The concomitant decrease in urinary magnesium excretion indicates that this likely is the consequence of reduced intestinal magnesium absorption. Based on these results, it might be of benefit to monitor magnesium status periodically in KTR on chronic PPI therapy.

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