scholarly journals Comparing safety of proton‐pump inhibitors versus H2‐receptor antagonists in kidney transplant recipients: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Keyhan Mohammadi ◽  
Shakila Yaribash ◽  
Bahman Razi ◽  
Simin Dashti‐Khavidaki
Keyword(s):  
Systematic Review ◽  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor

scholarly journals Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis

2019 ◽  
Vol 9 (2) ◽  
pp. 35-47 ◽  
Author(s):  
Boonphiphop Boonpheng ◽  
Charat Thongprayoon ◽  
Tarun Bathini ◽  
Konika Sharma ◽  
Michael A Mao ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Kidney Transplant ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW

2017 ◽  
Vol 54 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Ângelo Zambam de MATTOS ◽  
Gabriela Meirelles MARCHESE ◽  
Bárbara Brum FONSECA ◽  
Carlos KUPSKI ◽  
Marta Brenner MACHADO
Keyword(s):  
Systematic Review ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Reflux Disease ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor

ABSTRACT BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. Many patients are treated with these drugs for atypical manifestations attributed to gastroesophageal reflux, even that causal relation is not proven. OBJECTIVE: To evaluate the use of proton pump inhibitors and histamine H2 receptor antagonists in pediatric gastroesophageal reflux disease through a systematic review. METHODS: A systematic review was performed, using MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases. The search was limited to studies published in English, Portuguese or Spanish. There was no limitation regarding date of publication. Studies were considered eligible if they were randomized-controlled trials, evaluating proton pump inhibitors and/or histamine H2 receptor antagonists for the treatment of pediatric gastroesophageal reflux disease. Studies published only as abstracts, studies evaluating only non-clinical outcomes and studies exclusively comparing different doses of the same drug were excluded. Data extraction was performed by independent investigators. The study protocol was registered at PROSPERO platform (CRD42016040156). RESULTS: After analyzing 735 retrieved references, 23 studies (1598 randomized patients) were included in the systematic review. Eight studies demonstrated that both proton pump inhibitors and histamine H2 receptor antagonists were effective against typical manifestations of gastroesophageal reflux disease, and that there was no evidence of benefit in combining the latter to the former or in routinely prescribing long-term maintenance treatments. Three studies evaluated the effect of treatments on children with asthma, and neither proton pump inhibitors nor histamine H2 receptor antagonists proved to be significantly better than placebo. One study compared different combinations of omeprazole, bethanechol and placebo for the treatment of children with cough, and there is no clear definition on the best strategy. Another study demonstrated that omeprazole performed better than ranitidine for the treatment of extraesophageal reflux manifestations. Ten studies failed to demonstrate significant benefits of proton pump inhibitors or histamine H2 receptor antagonists for the treatment of unspecific manifestations attributed to gastroesophageal reflux in infants. CONCLUSION: Proton pump inhibitors or histamine H2 receptor antagonists may be used to treat children with gastroesophageal reflux disease, but not to treat asthma or unspecific symptoms.

Associations of Proton-Pump Inhibitors and H2 Receptor Antagonists with Chronic Kidney Disease: A Meta-Analysis

2017 ◽  
Vol 62 (10) ◽  
pp. 2821-2827 ◽  
Author(s):  
Karn Wijarnpreecha ◽  
Charat Thongprayoon ◽  
Supavit Chesdachai ◽  
Panadeekarn Panjawatanana ◽  
Patompong Ungprasert ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor

A systematic review of the efficacy of proton pump inhibitors (PPIs), H2 receptor antagonists (H2RAs) and prokinetics in maintenance therapy of esophagitis

2003 ◽  
Vol 124 (4) ◽  
pp. A108-A109
Author(s):  
Clare Donnellan ◽  
Naveen Sharma ◽  
Cathryn Preston ◽  
Brendan C. Delaney ◽  
David Forman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Maintenance Therapy ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor
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