Study on small airway function in asthmatics with fractional exhaled nitric oxide and impulse oscillometry

2016 ◽  
Vol 12 (2) ◽  
pp. 483-490 ◽  
Author(s):  
Lin Liu ◽  
Wen Liu ◽  
Chunhong Liu ◽  
Dexiang Wang ◽  
Jiping Zhao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Impulse Oscillometry ◽  
Fractional Exhaled Nitric Oxide ◽  
Airway Function

Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma

2017 ◽  
Vol 55 (7) ◽  
pp. 750-755 ◽  
Author(s):  
Chen Feng-jia ◽  
Huang Xin-yan ◽  
Lin Geng-peng ◽  
Liu Yang-li ◽  
Xie Can-mao
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Fractional Exhaled Nitric Oxide ◽  
Cough Variant Asthma ◽  
Airway Function

scholarly journals Diagnostic Value of Fractional Exhaled Nitric Oxide and Small Airway Function in Differentiating Cough-Variant Asthma from Typical Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yanqi Wang ◽  
Lixuan Zhao ◽  
Fang Chen ◽  
Yufeng Guo ◽  
Hongxia Ma ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Roc Curve ◽  
Provocation Test ◽  
Diagnostic Value ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Diagnostic Efficiency ◽  
Fractional Exhaled Nitric Oxide ◽  
Cough Variant Asthma ◽  
Airway Function

Purpose. To explore the diagnostic value of fractional exhaled nitric oxide (FeNO), small airway function, and a combined of both in differentiating cough-variant asthma (CVA) from typical asthma (TA). Methods. A total of 206 asthma subjects, including 104 CVA and 102 TA, were tested for pulmonary function, bronchial provocation test and FeNO. The correlation between FeNO, small airway function and other pulmonary indicators was analyzed by single correlation and multiple regression analysis. The receiver operating characteristic (ROC) curve was established to evaluate the diagnostic efficiency of FeNO, small airway function, and their combination and to predict the optimal cut-off point. Results. All the respiratory function parameters and small airway function indicators in TA group were significantly different from those in CVA group, and FeNO value was significantly higher than that in CVA group. In addition, the area under the ROC curve (AUC) was estimated to be 0.660 for FeNO, 0.895 for MMEF75%/25%, 0.873 for FEF50%, 0.898 for FEF25%, 0.695 for Fres, 0.650 for R5-R20, and 0.645 for X5. The optimal cut-off points of FeNO, MMEF75%/25%, FEF50%, FEF25%, Fres, R5-R20 and X5, were 48.50 ppb, 60.02%, 63.46%, 45.26%, 16.63 Hz, 0.38 kPa·L−1·s−1, and −1.32, respectively. And the AUC of FeNO combined with small airway function indexes FEF25%, Fres, R5-R20, and X5 were prior than single indicators. Conclusion. FeNO and small airway function indexes might have great diagnostic value for differentiating CVA from TA. The combination of FeNO and FEF25%, Fres, R5-R20, and X5 provided a significantly better prediction than either alone.

scholarly journals Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Children With Allergic Rhinitis

2014 ◽  
Vol 6 (1) ◽  
pp. 27 ◽  
Author(s):  
Yoon Hee Kim ◽  
Hyun Bin Park ◽  
Min Jung Kim ◽  
Hwan Soo Kim ◽  
Hee Seon Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Exhaled Nitric Oxide ◽  
Impulse Oscillometry ◽  
Fractional Exhaled Nitric Oxide

scholarly journals Trigger of Bronchial Hyperresponsiveness Development may not always need Eosinophilic Airway Inflammation in Very Early Stage of Asthma

2016 ◽  
Vol 7 (1) ◽  
pp. ar.2016.7.0145 ◽  
Author(s):  
Yasushi Obase ◽  
Terufumi Shimoda ◽  
Reiko Kishikawa ◽  
Shigeru Kohno ◽  
Tomoaki Iwanaga
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Vital Capacity ◽  
Bronchial Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Flow Volume ◽  
Impulse Oscillometry ◽  
Eosinophilic Inflammation ◽  
Fractional Exhaled Nitric Oxide ◽  
Sputum Eosinophils

Background Cough variant asthma (CVA), a suggested precursor of standard bronchial asthma (SBA), is characterized by positive bronchial hyperresponsiveness (BHR) and a chronic cough response to bronchodilator that persists for >8 weeks. Objective Airway inflammation, BHR, and airway obstructive damage were analyzed to assess whether CVA represents early or mild-stage SBA. Methods Patients with newly diagnosed CVA (n = 72) and SBA (n = 84) naive to oral or inhaled corticosteroids and without exacerbated asthma were subjected to spirometry, impulse oscillometry, BHR tests, sputum induction, and fractional exhaled nitric oxide measurements. Results In the patients with CVA, spirometry demonstrated higher forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio, FEV1 percent predicted, flow volume at 50% of vital capacity % predicted, and flow volume at 25% of vital capacity % predicted values, and impulse oscillometry demonstrated lower R5–Z20, AX, and Fres, and higher X5 values. In addition, the fractional exhaled nitric oxide and sputum eosinophil numbers were lower and the PC20 was higher than in patients with moderate SBA. However, these factors were similar in the patients with CVA and in the patients with intermittent mild SBA. A significantly smaller proportion of the patients with CVA had increased sputum eosinophils than the patients with intermittent mild SBA (p < 0.0001). However, interestingly, among the patients with CVA, no significant differences in the PC20 values were found between the patients with and those without increased sputum eosinophils. Conclusions All measures of central and peripheral airway obstruction, eosinophilic inflammation, and airway hyperresponsiveness in patients with CVA were milder than in patients with moderate SBA but were similar to those of patients with intermittent mild SBA. In CVA, the BHR was not affected by airway eosinophilic inflammation, which indicated that the very early development of BHR may not always need airway eosinophilic inflammation.

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