scholarly journals The value of small airway function parameters and fractional exhaled nitric oxide for predicting positive methacholine challenge test in asthmatics of different ages with FEV 1  ≥ 80% predicted

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lili Hou ◽  
Huijuan Hao ◽  
Gang Huang ◽  
Jinkai Liu ◽  
Li Yu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Challenge Test ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Fractional Exhaled Nitric Oxide ◽  
Methacholine Challenge ◽  
Methacholine Challenge Test ◽  
Airway Function ◽  
Different Ages

Study on small airway function in asthmatics with fractional exhaled nitric oxide and impulse oscillometry

2016 ◽  
Vol 12 (2) ◽  
pp. 483-490 ◽  
Author(s):  
Lin Liu ◽  
Wen Liu ◽  
Chunhong Liu ◽  
Dexiang Wang ◽  
Jiping Zhao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Impulse Oscillometry ◽  
Fractional Exhaled Nitric Oxide ◽  
Airway Function

Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma

2017 ◽  
Vol 55 (7) ◽  
pp. 750-755 ◽  
Author(s):  
Chen Feng-jia ◽  
Huang Xin-yan ◽  
Lin Geng-peng ◽  
Liu Yang-li ◽  
Xie Can-mao
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Fractional Exhaled Nitric Oxide ◽  
Cough Variant Asthma ◽  
Airway Function

scholarly journals Diagnostic Value of Fractional Exhaled Nitric Oxide and Small Airway Function in Differentiating Cough-Variant Asthma from Typical Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yanqi Wang ◽  
Lixuan Zhao ◽  
Fang Chen ◽  
Yufeng Guo ◽  
Hongxia Ma ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Roc Curve ◽  
Provocation Test ◽  
Diagnostic Value ◽  
Exhaled Nitric Oxide ◽  
Small Airway ◽  
Diagnostic Efficiency ◽  
Fractional Exhaled Nitric Oxide ◽  
Cough Variant Asthma ◽  
Airway Function

Purpose. To explore the diagnostic value of fractional exhaled nitric oxide (FeNO), small airway function, and a combined of both in differentiating cough-variant asthma (CVA) from typical asthma (TA). Methods. A total of 206 asthma subjects, including 104 CVA and 102 TA, were tested for pulmonary function, bronchial provocation test and FeNO. The correlation between FeNO, small airway function and other pulmonary indicators was analyzed by single correlation and multiple regression analysis. The receiver operating characteristic (ROC) curve was established to evaluate the diagnostic efficiency of FeNO, small airway function, and their combination and to predict the optimal cut-off point. Results. All the respiratory function parameters and small airway function indicators in TA group were significantly different from those in CVA group, and FeNO value was significantly higher than that in CVA group. In addition, the area under the ROC curve (AUC) was estimated to be 0.660 for FeNO, 0.895 for MMEF75%/25%, 0.873 for FEF50%, 0.898 for FEF25%, 0.695 for Fres, 0.650 for R5-R20, and 0.645 for X5. The optimal cut-off points of FeNO, MMEF75%/25%, FEF50%, FEF25%, Fres, R5-R20 and X5, were 48.50 ppb, 60.02%, 63.46%, 45.26%, 16.63 Hz, 0.38 kPa·L−1·s−1, and −1.32, respectively. And the AUC of FeNO combined with small airway function indexes FEF25%, Fres, R5-R20, and X5 were prior than single indicators. Conclusion. FeNO and small airway function indexes might have great diagnostic value for differentiating CVA from TA. The combination of FeNO and FEF25%, Fres, R5-R20, and X5 provided a significantly better prediction than either alone.

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