scholarly journals Deletion of Nf2 in neural crest‐derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region‐ and stage‐specific manner

2021 ◽  
Author(s):  
Mohamed Ishan ◽  
Guiqian Chen ◽  
Wenxin Yu ◽  
Zhonghou Wang ◽  
Marco Giovannini ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Neural Crest ◽  
Specific Manner ◽  
Hippo Signalling ◽  
Shape And Size

scholarly journals Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes

2000 ◽  
Vol 191 (8) ◽  
pp. 1281-1292 ◽  
Author(s):  
Raelene J. Grumont ◽  
Steve Gerondakis
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Nuclear Factor Κb ◽  
Wild Type ◽  
Cell Type ◽  
Regulatory Factor ◽  
Specific Manner ◽  
A Cell ◽  
Cell Type Specific ◽  
Interferon Regulatory Factor 4

In lymphocytes, the Rel transcription factor is essential in establishing a pattern of gene expression that promotes cell proliferation, survival, and differentiation. Here we show that mitogen-induced expression of interferon (IFN) regulatory factor 4 (IRF-4), a lymphoid-specific member of the IFN family of transcription factors, is Rel dependent. Consistent with IRF-4 functioning as a repressor of IFN-induced gene expression, the absence of IRF-4 expression in c-rel−/− B cells coincided with a greater sensitivity of these cells to the antiproliferative activity of IFNs. In turn, enforced expression of an IRF-4 transgene restored IFN modulated c-rel−/− B cell proliferation to that of wild-type cells. This cross-regulation between two different signaling pathways represents a novel mechanism that Rel/nuclear factor κB can repress the transcription of IFN-regulated genes in a cell type–specific manner.

scholarly journals Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Yunyun Jin ◽  
Jinjin Xu ◽  
Meng-Xin Yin ◽  
Yi Lu ◽  
Lianxin Hu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Chromatin Remodeling ◽  
Intestinal Stem Cells ◽  
Hippo Signaling ◽  
Protein Levels ◽  
Chromatin Remodeling Complex ◽  
Proliferation And Differentiation ◽  
Resistant Form ◽  
Specific Manner ◽  
Transcriptional Complex

Chromatin remodeling processes are among the most important regulatory mechanisms in controlling cell proliferation and regeneration. Drosophila intestinal stem cells (ISCs) exhibit self-renewal potentials, maintain tissue homeostasis, and serve as an excellent model for studying cell growth and regeneration. In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a lineage-specific manner. ISCs and enteroblasts exhibit high levels of Brm proteins; and without Brm, ISC proliferation and differentiation are impaired. Importantly, the Brm complex participates in ISC proliferation induced by the Scalloped–Yorkie transcriptional complex and that the Hippo (Hpo) signaling pathway directly restricted ISC proliferation by regulating Brm protein levels by inducing caspase-dependent cleavage of Brm. The cleavage resistant form of Brm protein promoted ISC proliferation. Our findings highlighted the importance of Hpo signaling in regulating epigenetic components such as Brm to control downstream transcription and hence ISC proliferation.

scholarly journals Cell proliferation drives neural crest cell invasion of the intestine

2007 ◽  
Vol 302 (2) ◽  
pp. 553-568 ◽  
Author(s):  
Matthew J. Simpson ◽  
Dong C. Zhang ◽  
Michael Mariani ◽  
Kerry A. Landman ◽  
Donald F. Newgreen
Keyword(s):  
Cell Proliferation ◽  
Neural Crest ◽  
Cell Invasion ◽  
Neural Crest Cell ◽  
Crest Cell

scholarly journals The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner

Glia ◽  
2018 ◽  
Vol 66 (9) ◽  
pp. 1947-1959 ◽  
Author(s):  
Minqing Jiang ◽  
Rohit Rao ◽  
Jincheng Wang ◽  
Jiajia Wang ◽  
Lingli Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Specific Manner

scholarly journals Cell Proliferation is Influenced by Bulbectomy and Normalized by Imipramine Treatment in a Region-Specific Manner

2005 ◽  
Vol 31 (6) ◽  
pp. 1165-1176 ◽  
Author(s):  
Gerburg Keilhoff ◽  
Axel Becker ◽  
Gisela Grecksch ◽  
Hans-Gert Bernstein ◽  
Gerald Wolf
Keyword(s):  
Cell Proliferation ◽  
Specific Manner

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

2005 ◽  
Vol 8 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Fisun Hamaratoglu ◽  
Maria Willecke ◽  
Madhuri Kango-Singh ◽  
Riitta Nolo ◽  
Eric Hyun ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Proliferation And Apoptosis ◽  
Hippo Signalling
Sign in / Sign up

Export Citation Format

Share Document