scholarly journals The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner

Glia ◽  
2018 ◽  
Vol 66 (9) ◽  
pp. 1947-1959 ◽  
Author(s):  
Minqing Jiang ◽  
Rohit Rao ◽  
Jincheng Wang ◽  
Jiajia Wang ◽  
Lingli Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Specific Manner

Is Decorin a Promising New Agent for Facial Nerve Regeneration? An Experimental Study

2021 ◽  
pp. 1-11
Author(s):  
Zehra Çınar ◽  
Ufuk Emre ◽  
Mehmet Gül ◽  
Özgür Yiğit ◽  
Elshan Mammadov ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Facial Nerve ◽  
Axonal Degeneration ◽  
Sham Group ◽  
Axon Diameter ◽  
Compound Muscle Action Potentials ◽  
Before And After ◽  
Potential Benefits ◽  
Group B

Objective: The aim of this study was to investigate the effects of systemic administration of decorin (DC) on facial nerve (FN) regeneration. Methods: A total of 32 female albino Wistar rats were divided into 4 groups: control (C) group: no bilateral FN neurorrhaphy (B-FNN), no DC application, sham-operated group: B-FNN without DC application, DC group: DC application without B-FNN, and B-FNN + DC group: B-FNN and DC application. Nerve conduction studies were performed before and after skin incisions at 1st, 3rd, 5th, and 7th weeks in all groups. The amplitude and latency of compound muscle action potentials were recorded. FN samples were obtained and were investigated under light microscopy and immunohistochemical staining. The nerve and axon diameter, number of axons, H score, Schwann cell proliferation, and myelin and axonal degeneration were recorded quantitatively. Results: In the sham group, the 3rd and 5th postoperative week, amplitude values were significantly lower than those of the B-FNN + DC group (p < 0.05). Nerve diameters were found to be significantly larger in the sham, DC, and B-FNN + DC groups than in the C group (p < 0.05). The number of axons, the axon diameter, and the H scores were found to be significantly higher in the B-FNN + DC group than in the sham group (p < 0.05). The Schwann cell proliferation, myelin degeneration, and axonal degeneration scores were significantly lower in the B-FNN + DC group than in the sham group (p < 0.05). Conclusion: Electrophysiological and histopathological evaluation revealed the potential benefits provided by DC. This agent may increase FN regeneration.

scholarly journals Transcriptional regulation of miR-30a by YAP impacts PTPN13 and KLF9 levels and Schwann cell proliferation

2021 ◽  
pp. 100962
Author(s):  
Alyssa Shepard ◽  
Sany Hoxha ◽  
Scott Troutman ◽  
David Harbaugh ◽  
Michael S. Kareta ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Regulation ◽  
Schwann Cell

scholarly journals Miz1 Controls Schwann Cell Proliferation via H3K36me2 Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination

2017 ◽  
Vol 38 (4) ◽  
pp. 858-877 ◽  
Author(s):  
David Fuhrmann ◽  
Marco Mernberger ◽  
Andrea Nist ◽  
Thorsten Stiewe ◽  
Hans-Peter Elsässer
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Peripheral Nerve

scholarly journals Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes

2000 ◽  
Vol 191 (8) ◽  
pp. 1281-1292 ◽  
Author(s):  
Raelene J. Grumont ◽  
Steve Gerondakis
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Nuclear Factor Κb ◽  
Wild Type ◽  
Cell Type ◽  
Regulatory Factor ◽  
Specific Manner ◽  
A Cell ◽  
Cell Type Specific ◽  
Interferon Regulatory Factor 4

In lymphocytes, the Rel transcription factor is essential in establishing a pattern of gene expression that promotes cell proliferation, survival, and differentiation. Here we show that mitogen-induced expression of interferon (IFN) regulatory factor 4 (IRF-4), a lymphoid-specific member of the IFN family of transcription factors, is Rel dependent. Consistent with IRF-4 functioning as a repressor of IFN-induced gene expression, the absence of IRF-4 expression in c-rel−/− B cells coincided with a greater sensitivity of these cells to the antiproliferative activity of IFNs. In turn, enforced expression of an IRF-4 transgene restored IFN modulated c-rel−/− B cell proliferation to that of wild-type cells. This cross-regulation between two different signaling pathways represents a novel mechanism that Rel/nuclear factor κB can repress the transcription of IFN-regulated genes in a cell type–specific manner.

Up-Regulation of NF45 Correlates with Schwann Cell Proliferation After Sciatic Nerve Crush

2015 ◽  
Vol 56 (1) ◽  
pp. 216-227 ◽  
Author(s):  
Youhua Wang ◽  
Shiran Zhou ◽  
Hua Xu ◽  
Shixian Yan ◽  
Dawei Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sciatic Nerve ◽  
Schwann Cell ◽  
Sciatic Nerve Crush ◽  
Nerve Crush

scholarly journals Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Yunyun Jin ◽  
Jinjin Xu ◽  
Meng-Xin Yin ◽  
Yi Lu ◽  
Lianxin Hu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Chromatin Remodeling ◽  
Intestinal Stem Cells ◽  
Hippo Signaling ◽  
Protein Levels ◽  
Chromatin Remodeling Complex ◽  
Proliferation And Differentiation ◽  
Resistant Form ◽  
Specific Manner ◽  
Transcriptional Complex

Chromatin remodeling processes are among the most important regulatory mechanisms in controlling cell proliferation and regeneration. Drosophila intestinal stem cells (ISCs) exhibit self-renewal potentials, maintain tissue homeostasis, and serve as an excellent model for studying cell growth and regeneration. In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a lineage-specific manner. ISCs and enteroblasts exhibit high levels of Brm proteins; and without Brm, ISC proliferation and differentiation are impaired. Importantly, the Brm complex participates in ISC proliferation induced by the Scalloped–Yorkie transcriptional complex and that the Hippo (Hpo) signaling pathway directly restricted ISC proliferation by regulating Brm protein levels by inducing caspase-dependent cleavage of Brm. The cleavage resistant form of Brm protein promoted ISC proliferation. Our findings highlighted the importance of Hpo signaling in regulating epigenetic components such as Brm to control downstream transcription and hence ISC proliferation.

Sign in / Sign up

Export Citation Format

Share Document