scholarly journals Primordial germ cell-like cells derived from canine adipose mesenchymal stem cells

2016 ◽  
Vol 49 (4) ◽  
pp. 503-511 ◽  
Author(s):  
Yudong Wei ◽  
Jia Fang ◽  
Shufang Cai ◽  
Changrong Lv ◽  
Shiqiang Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Adipose Mesenchymal Stem Cells

scholarly journals Ghrelin peptide improves glial conditioned medium effects on neuronal differentiation of human adipose mesenchymal stem cells

2021 ◽  
Author(s):  
Cristina Russo ◽  
Giuliana Mannino ◽  
Martina Patanè ◽  
Nunziatina Laura Parrinello ◽  
Rosalia Pellitteri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Conditioned Medium ◽  
Neural Differentiation ◽  
Conditioned Media ◽  
Glial Fibrillary Acid Protein ◽  
Ghrelin Receptor ◽  
Neuronal Markers ◽  
Adipose Mesenchymal Stem Cells ◽  
Marker Expression

AbstractThe influences of ghrelin on neural differentiation of adipose-derived mesenchymal stem cells (ASCs) were investigated in this study. The expression of typical neuronal markers, such as protein gene product 9.5 (PGP9.5) and Microtubule Associated Protein 2 (MAP2), as well as glial Fibrillary Acid Protein (GFAP) as a glial marker was evaluated in ASCs in different conditions. In particular, 2 µM ghrelin was added to control ASCs and to ASCs undergoing neural differentiation. For this purpose, ASCs were cultured in Conditioned Media obtained from Olfactory Ensheathing cells (OEC-CM) or from Schwann cells (SC-CM). Data on marker expression were gathered after 1 and 7 days of culture by fluorescence immunocytochemistry and flow cytometry. Results show that only weak effects were induced by the addition of only ghrelin. Instead, dynamic ghrelin-induced modifications were detected on the increased marker expression elicited by glial conditioned media. In fact, the combination of ghrelin and conditioned media consistently induced a further increase of PGP9.5 and MAP2 expression, especially after 7 days of treatment. The combination of ghrelin with SC-CM produced the most evident effects. Weak or no modifications were found on conditioned medium-induced GFAP increases. Observations on the ghrelin receptor indicate that its expression in control ASCs, virtually unchanged by the addition of only ghrelin, was considerably increased by CM treatment. These increases were enhanced by combining ghrelin and CM treatment, especially at 7 days. Overall, it can be assumed that ghrelin favors a neuronal rather than a glial ASC differentiation.

Insulin-Producing Cells Differentiated from Adipose Mesenchymal Stem Cells Neuroprotection Strategy in Diabetic Rats

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154658
Author(s):  
K.M. Wartchow ◽  
L. Rodrigues ◽  
N.G. Selistre ◽  
L. Lissner ◽  
A. Moreira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Diabetic Rats ◽  
Insulin Producing Cells ◽  
Adipose Mesenchymal Stem Cells

scholarly journals Primordial Germ Cell-Like Cells Differentiated In Vitro from Skin-Derived Stem Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8263 ◽  
Author(s):  
Katja Linher ◽  
Paul Dyce ◽  
Julang Li
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell

scholarly journals Pre-Exposure of Human Adipose Mesenchymal Stem Cells to Soluble Factors Enhances Their Homing to Brain Cancer

2015 ◽  
Vol 4 (3) ◽  
pp. 239-251 ◽  
Author(s):  
Chris L. Smith ◽  
Kaisorn L. Chaichana ◽  
Young M. Lee ◽  
Benjamin Lin ◽  
Kevin M. Stanko ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Cancer ◽  
Soluble Factors ◽  
Adipose Mesenchymal Stem Cells

scholarly journals Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration

2021 ◽  
pp. 102482
Author(s):  
Tito Sumarwoto ◽  
Heri Suroto ◽  
Ferdiansyah Mahyudin ◽  
Dwikora Novembri Utomo ◽  
Romaniyanto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Adipose Mesenchymal Stem Cells
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