scholarly journals Modulating effect ofd-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis

2013 ◽  
Vol 46 (6) ◽  
pp. 705-720 ◽  
Author(s):  
R. Vinothkumar ◽  
M. Sudha ◽  
P. Viswanathan ◽  
J. Kabalimoorthy ◽  
T. Balasubramanian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Model ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
Neoplastic Lesions

Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis

2021 ◽  
pp. 1-11
Author(s):  
Pollyanna Francielli De Oliveira ◽  
Luis Fernando Leandro ◽  
Ricardo Andrade Furtado ◽  
Natália Helen Ferreira ◽  
Patrícia Mendonça Pauletti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
Brazilian Cerrado ◽  
Preneoplastic Lesions ◽  
Typical Species ◽  
And Oxidative Stress

scholarly journals Annona crassiflora Mart. fruit pulp effects on biochemical parameters and rat colon carcinogenesis

2013 ◽  
Vol 37 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Vinícius Paula Venâncio ◽  
Eric Batista Ferreira ◽  
Maísa Ribeiro Pereira Lima Brigagão ◽  
Fernanda Borges de Araújo Paula ◽  
Luis Fernando Barbisan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cellular Localization ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Nuclear Antigen ◽  
Rat Colon ◽  
Commercial Diet

A. crassiflora Mart. a Brazilian savannah fruit, is a source of phytochemical compounds that possess a wide array of biological activities, including free radical scavenging. This native fruit proved to potentialize the mutagenic process in previous in vivo investigations. The aim of the present study was to investigate the effects of A. crassiflora Mart. pulp intake on colonic cell proliferation and on the development of Aberrant Crypt Foci (ACF) in male Wistar rats. The animals were fed with either a commercial diet or a diet supplemented with A. crassiflora Mart. pulp mixed in 1%, 10% or 20% (w/w) for 4 weeks or 20 weeks. The carcinogen 1,2-dimethylhydrazine dihydrochloride (4 doses, 40 mg kg-1 each) was used to induce colonic ACF. After euthanasia, the blood, liver and colon samples were collected for biochemical determinations, oxidative stress or ACF development analysis, respectively. Immunohistochemical analyses of the colonic mucosa were performed using antibodies against proliferating cell nuclear antigen (PCNA) in normal-appearing colonic crypt and β-catenin in ACF. There was no ACF development in the colon from groups treated with A. crassiflora Mart. pulp. Also, the biochemical and oxidative stress analysis, PCNA labeling and ACF development (number, multiplicity or cellular localization of β-catenin) were unchanged as a result of marolo pulp intake. Thus, the present results suggest that A. crassiflora Mart. pulp intake did not exert any protective effect in the colon carcinogenesis induced by DMH in rats.

Grape juice concentrate (G8000™) modulates apoptosis but not oxidative stress following rat colon carcinogenesis induced by azoxymethane

2015 ◽  
Vol 25 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Celina Tizuko Fujiyama Oshima ◽  
Gilles Landman ◽  
Ana Paula Ribeiro Paiotti ◽  
Ricardo Artigiani Neto ◽  
Roseane Mendes Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colon Carcinogenesis ◽  
Grape Juice ◽  
Rat Colon ◽  
Juice Concentrate

McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis

Life Sciences ◽  
2021 ◽  
Vol 272 ◽  
pp. 119194
Author(s):  
Diva de Aguiar Magalhães ◽  
Jalles Arruda Batista ◽  
Stefany Guimarães Sousa ◽  
Jayro dos Santos Ferreira ◽  
Lauanda da Rocha Rodrigues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Experimental Model ◽  
Muscarinic Agonist ◽  
And Oxidative Stress
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