The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy

2021 ◽  
Author(s):  
Fiona A. Ross ◽  
James H. Park ◽  
David Mansouri ◽  
Cariss Little ◽  
Domenic G. Di Rollo ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Faecal Calprotectin

scholarly journals Ethnic and Sex Disparities in Colorectal Neoplasia Among Hispanic Patients Undergoing Screening Colonoscopy

2012 ◽  
Vol 10 (9) ◽  
pp. 997-1001 ◽  
Author(s):  
Liselle Lathroum ◽  
Fernando Ramos–Mercado ◽  
Jessica Hernandez–Marrero ◽  
Myriam Villafaña ◽  
Marcia Cruz–Correa
Keyword(s):  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Hispanic Patients ◽  
Sex Disparities

scholarly journals Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Juan Lasa ◽  
Astrid Rausch ◽  
Luis Florez Bracho ◽  
Josefina Altamirano ◽  
Daniela Speisky ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Colorectal Adenoma ◽  
Colorectal Neoplasia ◽  
Adult Patients ◽  
Colorectal Adenomas ◽  
Screening Colonoscopy ◽  
Advanced Adenoma ◽  
Adenoma Detection ◽  
Adult Celiac Disease ◽  
Recent Diagnosis

Background. The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims. To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods. A retrospective case-control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptomatic subjects undertaking screening colonoscopy were recruited as controls in a 2 : 1 fashion. The prevalence of colorectal adenomas and the prevalence of advanced adenomas were compared between groups. Results. 57 celiac disease patients and 118 controls were enrolled. There was a greater prevalence of female patients among the celiac group, with no significant differences in terms of age. There were more obese patients among controls and a higher proportion of tabaquism among celiac patients. Adenoma prevalence was significantly higher among celiac patients (47.37% versus 27.97%, p=0.01). Advanced adenoma detection was not different between groups. Conclusion. Adult patients with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas.

scholarly journals A Risk Prediction Index for Advanced Colorectal Neoplasia at Screening Colonoscopy

2015 ◽  
Vol 110 (7) ◽  
pp. 1062-1071 ◽  
Author(s):  
Paul C Schroy ◽  
John B Wong ◽  
Michael J OʼBrien ◽  
Clara A Chen ◽  
John L Griffith
Keyword(s):  
Risk Prediction ◽  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Advanced Colorectal Neoplasia

scholarly journals Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Theodore F. Shapero ◽  
Grant I. Chen ◽  
Tim Devlin ◽  
Alison Gibbs ◽  
Iain C. Murray ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Binary Logistic Regression ◽  
Screening Colonoscopy ◽  
Multinomial Regression ◽  
Community Based ◽  
Canadian Population ◽  
Colonic Neoplasia ◽  
Older Subjects ◽  
Advanced Adenomas ◽  
Tobacco Usage

Background and Aims. Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods. We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded. Odds for adenomas (A) and advanced adenomas (ADV) in overweight (BMI 25.1–30) and obese (BMI > 30) subjects were assessed by multinomial regression, adjusted for covariates. Analyses included relationships between HL, HT, DM, age, tobacco usage, and neoplasia. Discriminatory power of HT, HL, DM, and BMI for neoplasia was assessed by binary logistic regression. Odds were calculated for neoplasia in each colonic segment related to BMI. Results. A and ADV were commoner in overweight and obese males, obese females, older subjects, and smokers. HL, HT, and DM were associated with increased odds for neoplasia, significantly for A with hypertension. BMI alone predicted neoplasia as well as HT, HL, DM, or combinations thereof. All segments of the colon were affected. Multiple polyps were particularly prevalent in the obese. Conclusions. Obesity and MetS are risk factors for colonic neoplasia in a Canadian population.

Five-Year Risk of Colorectal Neoplasia among Persons with No Neoplasia on Baseline Screening Colonoscopy

2006 ◽  
Vol 101 ◽  
pp. S551-S552
Author(s):  
Thomas F. Imperiale ◽  
James D. Rogge ◽  
Elizabeth A. Glowinski ◽  
Ching L. Cooper ◽  
Gregory N. Larkin ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Baseline Screening

Predictors of advanced colorectal neoplasia in colorectal cancer screening – interim results of multicentric prospective study

2020 ◽  
Vol 74 (5) ◽  
pp. 386-392
Author(s):  
Tomáš Grega ◽  
Gabriela Vojtěchová ◽  
Michal Voška ◽  
Ondřej Májek ◽  
Miroslav Zavoral ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Prospective Study ◽  
Colorectal Neoplasia ◽  
Serum Triglyceride ◽  
Screening Colonoscopy ◽  
Factors Associated ◽  
Primary Screening ◽  
Advanced Colorectal Neoplasia ◽  
Screening Population

ntroduction: The incidence of advanced colorectal neoplasia in the screening population shows great diversity with a prevalence of 3–12 %. Due to the uneven distribution in the population, potential risk factors that would allow the stratification of individuals according to the degree of risk of colorectal neoplasia are searched. Aim: To determine the risk factors associated with the occurrence of advanced colorectal neoplasia in the screening population. Methods: Asymptomatic individuals aged 45–75 years who underwent preventive colonoscopy in 2012–2016 in a multicenter prospective study monitoring metabolic risk factors for CRC (MRF CRC study) were included in the analysis. Data were analyzed using descriptive statistics. The Fisher’s exact test was used to compare the risk factors with the occurrence of advanced colorectal neoplasia. Results: There were 1,108 men (56.3%) and 859 women (43.7%) in the group; the average age of the individuals was 60 years. The majority of subjects were referred for primary screening colonoscopy (1,174 subjects; 59.7%) and 793 subjects (40.3%) underwent FOBT positive colonoscopy. The total number of advanced colorectal neoplasms in the cohort was 11,8% (233 individuals). The independent risk factors significantly associated with advanced colorectal neoplasia included age (p < 0.001), male gender (p = 0.001), smoking (p < 0.001), serum concentrations of triglycerides (p = 0.029; especially concentrations > 2 mmol/l) and low vitamin D (p = 0.033). These are preliminary results which will be specified in the following more detailed data analysis using logistic regression. Conclusion: The strongest risk factors associated with advanced colorectal neoplasia were age, gender and smoking. In addition to these factors, serum triglyceride levels and low vitamin D were significantly associated with advanced colorectal neoplasia. In the individuals with a higher incidence of advanced colorectal neoplasia according to the given factors, primary screening colonoscopy should be considered.

scholarly journals Role of S100 Proteins in Colorectal Carcinogenesis

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Paula Moravkova ◽  
Darina Kohoutova ◽  
Stanislav Rejchrt ◽  
Jiri Cyrany ◽  
Jan Bures
Keyword(s):  
Calcium Binding ◽  
Colorectal Neoplasia ◽  
Serum Levels ◽  
S100 Proteins ◽  
Colorectal Carcinogenesis ◽  
Invasion And Migration ◽  
Common Cancer ◽  
The Family ◽  
And Migration

The family of S100 proteins represents 25 relatively small (9–13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activate NF-κβsignaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. The expression of S100 proteins in the cancerous tissue and serum levels of S100 proteins might be used as a precise diagnostic and prognostic marker in patients with suspected or already diagnosed colorectal neoplasia. Possibly, in the future, S100 proteins will be a therapeutic target for tailored anticancer therapy.

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