scholarly journals Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Juan Lasa ◽  
Astrid Rausch ◽  
Luis Florez Bracho ◽  
Josefina Altamirano ◽  
Daniela Speisky ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Colorectal Adenoma ◽  
Colorectal Neoplasia ◽  
Adult Patients ◽  
Colorectal Adenomas ◽  
Screening Colonoscopy ◽  
Advanced Adenoma ◽  
Adenoma Detection ◽  
Adult Celiac Disease ◽  
Recent Diagnosis

Background. The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims. To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods. A retrospective case-control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptomatic subjects undertaking screening colonoscopy were recruited as controls in a 2 : 1 fashion. The prevalence of colorectal adenomas and the prevalence of advanced adenomas were compared between groups. Results. 57 celiac disease patients and 118 controls were enrolled. There was a greater prevalence of female patients among the celiac group, with no significant differences in terms of age. There were more obese patients among controls and a higher proportion of tabaquism among celiac patients. Adenoma prevalence was significantly higher among celiac patients (47.37% versus 27.97%, p=0.01). Advanced adenoma detection was not different between groups. Conclusion. Adult patients with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas.

scholarly journals THE IMPACT OF COLORECTAL CHROMENDOSCOPY WITH ENHANCED MUCOSAL IMAGING ON ADENOMA MISS RATE IN SCREENING COLONOSCOPY

2021 ◽  
Vol 58 (4) ◽  
pp. 450-455
Author(s):  
Bruna Suelen Raymundo LUZ ◽  
Juliana Carneiro Cabral Dourado CANTERAS ◽  
Karen de Carvalho GON ◽  
Maria Luisa de Deus BATISTA ◽  
Thomy Jun AHN ◽  
...  
Keyword(s):  
Colorectal Adenoma ◽  
Detection Rate ◽  
Colorectal Neoplasia ◽  
Screening Colonoscopy ◽  
Neoplastic Lesion ◽  
Adenoma Detection ◽  
Incidence And Mortality ◽  
Group 2 ◽  
The Impact ◽  
Group 1

ABSTRACT BACKGROUND: Colonoscopy is the gold standard for the diagnosis and treatment of adenomas. It is related with decreased colorectal cancer incidence and mortality. However, an important problem is missed colorectal adenoma. All efforts should be undertaken to reduce this rate. Enhancing imaging technologies including electronic chromoendoscopy and magnification has been increasingly adopted for improving the colorectal neoplasia detection rate and the detailed study of its surface, as well. I-scan images (Pentax, Tokyo, Japan) provides virtual chromoendoscopy in real-time during the examination to view the surface pattern, highlighting the microvasculature of the neoplastic lesion. The evidence on the impact of the use of I-scan on the colorectal adenoma detection rate is scarce. OBJECTIVE: To evaluate whether the use of I-scan has impact on the adenoma miss rate (AMR) of screening colonoscopy exams. METHODS: Observational and prospective study conducted by monitoring patients over 50 years undergoing colonoscopy. There were two groups: Group 1 - first inspection with standard high-definition white-light (HDWL) followed by a second inspection with I-scan 1; Group 2 - first inspection with I-scan 1 followed by a second inspection with standard HDWL. The primary outcome was the AMR from the first exam, calculated with the number of adenomas detected in the second exam, divided by the total number of adenomas detected in both exams. RESULTS: A total of 85 patients participated in the study. 14 were excluded, with a final sample of 71 patients, in the Group 1, 34 patients, and the Group 2, 37. A total of 58 adenomas were detected, 40 in the first inspection (20 in each group) and 18 in the second inspection in group 1. The overall AMR was higher for the Group 1 than the Group 2 (47.4% vs 0% P=0.0002). CONCLUSION: The use of I-scan 1 during colonoscopy exam reduces the AMR.

scholarly journals Type 2 diabetes impacts colorectal adenoma detection in screening colonoscopy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lorenzo F. Ottaviano ◽  
Xueying Li ◽  
Matthew Murray ◽  
Jesse T. Frye ◽  
Brandon E. Lung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Colorectal Adenoma ◽  
Screening Colonoscopy ◽  
Adenoma Detection

scholarly journals Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis

mBio ◽  
2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Minsuk Kim ◽  
Emily Vogtmann ◽  
David A. Ahlquist ◽  
Mary E. Devens ◽  
John B. Kisiel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Colorectal Adenoma ◽  
Precancerous Lesions ◽  
Colorectal Adenomas ◽  
Advanced Adenoma ◽  
Bioactive Lipids ◽  
Gut Microbes ◽  
Cancer Pathogenesis ◽  
Composition Profiles

ABSTRACT Colorectal adenomas are precancerous lesions of colorectal cancer (CRC) that offer a means of viewing the events key to early CRC development. A number of studies have investigated the changes and roles of gut microbiota in adenoma and carcinoma development, highlighting its impact on carcinogenesis. However, there has been less of a focus on the gut metabolome, which mediates interactions between the host and gut microbes. Here, we investigated metabolomic profiles of stool samples from patients with advanced adenoma (n = 102), matched controls (n = 102), and patients with CRC (n = 36). We found that several classes of bioactive lipids, including polyunsaturated fatty acids, secondary bile acids, and sphingolipids, were elevated in the adenoma patients compared to the controls. Most such metabolites showed directionally consistent changes in the CRC patients, suggesting that those changes may represent early events of carcinogenesis. We also examined gut microbiome-metabolome associations using gut microbiota profiles in these patients. We found remarkably strong overall associations between the microbiome and metabolome data and catalogued a list of robustly correlated pairs of bacterial taxa and metabolomic features which included signatures of adenoma. Our findings highlight the importance of gut metabolites, and potentially their interplay with gut microbes, in the early events of CRC pathogenesis. IMPORTANCE Colorectal adenomas are precursors of CRC. Recently, the gut microbiota, i.e., the collection of microbes residing in our gut, has been recognized as a key player in CRC development. There have been a number of gut microbiota profiling studies for colorectal adenoma and CRC; however, fewer studies have considered the gut metabolome, which serves as the chemical interface between the host and gut microbiota. Here, we conducted a gut metabolome profiling study of colorectal adenoma and CRC and analyzed the metabolomic profiles together with paired microbiota composition profiles. We found several chemical signatures of colorectal adenoma that were associated with some gut microbes and potentially indicative of future CRC. This study highlights potential early-driver metabolites in CRC pathogenesis and guides further targeted experiments and thus provides an important stepping stone toward developing better CRC prevention strategies.

scholarly journals A sex-specific propensity-adjusted analysis of colonic adenoma detection rates in a screening cohort

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sarah Wernly ◽  
Bernhard Wernly ◽  
Georg Semmler ◽  
Sebastian Bachmayer ◽  
David Niederseer ◽  
...  
Keyword(s):  
Propensity Score ◽  
Colorectal Adenoma ◽  
Sensitivity Analyses ◽  
Screening Colonoscopy ◽  
Advanced Adenoma ◽  
Age Group ◽  
Detection Rates ◽  
Group 3 ◽  
Propensity Score Adjustment ◽  
Group 1

AbstractThe prevalence of colorectal adenoma and advanced adenoma (AA) differs between sexes. Also, the optimal age for the first screening colonoscopy is under debate. We, therefore, performed a sex-specific and age-adjusted comparison of adenoma, AA and advanced neoplasia (AN) rates in a real-world screening cohort. In total, 2824 asymptomatic participants between 45- and 60-years undergoing screening colonoscopy at a single-centre in Austria were evaluated. 46% were females and mean age was 53 ± 4 years. A propensity score for being female was calculated, and adenoma, AA and AN detection rates evaluated using uni- and multivariable logistic regression. Sensitivity analyses for three age groups (group 1: 45 to 49 years, n = 521, 41% females, mean age 47 ± 1 years; group 2: 50 to 54 years, n = 1164, 47% females, mean age 52 ± 1 years; group 3: 55 to 60 years, n = 1139, 46% females, mean age 57 ± 2 years) were performed. The prevalence of any adenoma was lower in females (17% vs. 30%; OR 0.46, 95% CI 0.38–0.55; p < 0.001) and remained so after propensity score adjustment for baseline characteristics and lifestyle factors (aOR 0.52, 95% CI 0.41–0.66; p < 0.001). The same trend was seen for AA with a significantly lower prevalence in females (3% vs. 7%; OR 0.38, 95% CI 0.26–0.55; p < 0.001) that persisted after propensity score adjustment (aOR 0.54, 95% CI 0.34–0.86; p = 0.01). Also, all age-group sensitivity analyses showed lower adenoma, AA and AN rates in females. Similar numbers needed to screen to detect an adenoma, an AA or AN were found in female age group 3 and male age group 1. Colorectal adenoma, AA and AN were consistently lower in females even after propensity score adjustment and in all age-adjusted sensitivity analyses. Our study may add to the discussion of the optimal age for initial screening colonoscopy which may differ between the sexes.

Diagnostic yield of early repeat colonoscopy after suboptimal bowel preparation in a fecal immunochemical test-based screening program

Endoscopy ◽  
2020 ◽  
Vol 52 (12) ◽  
pp. 1093-1100 ◽  
Author(s):  
Sandra Baile-Maxía ◽  
Carolina Mangas-Sanjuan ◽  
Lucía Medina-Prado ◽  
Juan Martínez-Sempere ◽  
Oscar Murcia ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Screening Program ◽  
Diagnostic Yield ◽  
Fecal Immunochemical Test ◽  
High Rate ◽  
Screening Colonoscopy ◽  
Advanced Adenoma ◽  
Adenoma Detection ◽  
Immunochemical Test ◽  
Repeat Colonoscopy

Abstract Background Current guidelines regarding surveillance after screening colonoscopy assume adequate bowel preparation. However, follow-up intervals after suboptimal cleansing are highly heterogeneous. We aimed to determine the diagnostic yield of early repeat colonoscopy in patients with suboptimal bowel preparation in fecal immunochemical test (FIT)-based screening colonoscopy. Methods An observational study including patients who underwent colonoscopy with suboptimal bowel preparation after positive FIT screening and then repeat colonoscopy within 1 year. Suboptimal preparation was defined as a Boston Bowel Preparation Scale (BBPS) score of 1 in any segment. Patients with a BBPS score of 0 in any segment or incomplete examination were excluded. The adenoma detection rate (ADR), advanced ADR (AADR), and colorectal cancer rate were calculated for the index and repeat colonoscopies. Results Of the 2474 patients with FIT-positive colonoscopy at our center during this period, 314 (12.7 %) had suboptimal preparation. Of the 259 (82.5 %) patients who underwent repeat colonoscopy, suboptimal cleansing persisted in 22 (9 %). On repeat colonoscopy, the ADR was 38.7 % (95 %CI 32.6 % to 44.8 %) and the AADR was 14.9 % (95 %CI 10.5 % to 19.4 %). The per-adenoma miss rate was 27.7 % (95 %CI 24.0 % to 31.6 %), and the per-advanced adenoma miss rate was 17.6 % (95 %CI 13.3 % to 22.7 %). After repeat colonoscopy, the post-polypectomy surveillance recommendation changed from 10 to 3 years in 14.7 % of the patients with previous 10-year surveillance recommendation. Conclusions Patients with suboptimal bowel preparation on FIT-positive colonoscopy present a high rate of advanced adenomas in repeat colonoscopy, with major changes in post-polypectomy surveillance recommendations.

Su1237 Effect of Fellow Participation in Screening Colonoscopy on Adenoma and Advanced Adenoma Detection Rates

2014 ◽  
Vol 146 (5) ◽  
pp. S-410
Author(s):  
Anand S. Shah ◽  
Heval Mohamed Kelli ◽  
Lauren M. Shea ◽  
Stephan U. Goebel ◽  
Emad S. Qayed
Keyword(s):  
Screening Colonoscopy ◽  
Advanced Adenoma ◽  
Detection Rates ◽  
Adenoma Detection ◽  
Adenoma Detection Rates

scholarly journals Evaluation of Thyroid Dysfunction in Adult Patients of Celiac Disease

2021 ◽  
Vol 8 (4) ◽  
pp. 3-8
Author(s):  
Nauman Wazir ◽  
Shafqat Ur Rehman
Keyword(s):  
Celiac Disease ◽  
Thyroid Dysfunction ◽  
Adult Patients ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Thyroid Peroxidase ◽  
Serological Evidence ◽  
Adult Celiac Disease ◽  
Significant Difference ◽  
And Control

OBJECTIVES: To assess free thyroxine (fT4), thyroid stimulating hormone (TSH), and anti thyroid peroxidase antibodies (anti TPO abs) in adult Celiac disease patients and non-celiac controls and to find out any statistically significant difference in their corresponding means between the two groups. METHODOLOGY: The study design was analytical cross sectional. Sixty adult patients of celiac disease (CD) and 30 apparently healthy non-celiac adults were included in the study. CD patients had earlier been diagnosed by elevated levels of serological evidence of elevated (greater than 15X ULN) anti tissue transglutaminase (TTG) (IgA class) antibodies. CD was ruled out in the control group by normal levels of the antibodies. TSH, fT4 and anti TPO abs were obtained from all individuals of CD patient and control groups. RESULTS: Mean age of Celiac disease in patients was 23.85±5.43 years. Mean age of individuals in the control group was 24.26±5.55 years. Statistically significant difference in mean TSH and anti-TPO abs levels between the CD patient group and control group (p values of 0.03 and 0.038, respectively) was present. No statistically significant difference was seen between mean fT4 of patients and control group (p=0.74). Subclinical and overt hypothyroidism was present in 10% and 5% of CD patients, while anti TPO abs was positive in 16.6% of CD patients. CONCLUSION: There is a considerably high prevalence of subclinical and overt hypothyroidism as well as serological evidence of thyroid dysfunction in adult patients of CD.

scholarly journals What happens to adiponectin, resistin and apelin-12 in colorectal adenomas? A cross sectional study.

2020 ◽  
Author(s):  
oguz dikbas ◽  
Ülkü Dagli ◽  
Handan Ankarali ◽  
Buket Kin Tekce ◽  
Fahri Yılmaz ◽  
...  
Keyword(s):  
Colorectal Neoplasia ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Colorectal Adenomas ◽  
Screening Colonoscopy ◽  
Cross Sectional ◽  
Oncogenic Potential ◽  
Control Approach ◽  
Arterial Blood ◽  
Study Results

Abstract BackgroundColorectal adenomas are precancerous neoplastic lesions which may potentially differentiate to the colorectal carcinoma. We investigated whether adiponectin, resistin and apelin 12 serum levels might change in case of colorectal neoplasia. Aims In this study we intended to determine relationship between serum levels of adiponectin, resistin, apelin-12 and presence of colorectal adenoma using case-control approach. Methods Patients undergoing screening colonoscopy in the Abant Izzet Baysal University Medical Faculty Gastroenterology Polyclinics between years 2010 and 2013 were selected for study. Results In this study there were not any difference between groups according to age, body mass index, waist circumference and mean arterial blood pressure (all p>0.05). Adiponectin, resistin and apelin-12 serum levels were not statistically different between groups (p=0.642, p=0.890, p=0.618; respectively). On the other side: Serum apelin-12 levels were found to be statistically higher in patients with severe dysplastic adenoma group compared to both non-dysplastic and without adenoma groups (p=0.014). There was a negative correlation between the number of colorectal adenomas and serum adiponectin levels (p=0.035, r=-0.41). Conclusion Apelin-12 does increase in severe dysplastic adenomas. Apelin-12 is an angiogenic adipocytokine with oncogenic potential. The relation between cancer development and apelin has been shown in different types of tumors. Apelin-12 might be a candidate marker for detecting dysplastic colorectal adenomas.

Mo1028 - Prevalence of Colorectal Adenomas Among Recentlydiagnosed Adult Celiac Disease Patients

2018 ◽  
Vol 154 (6) ◽  
pp. S-676
Author(s):  
Juan S. Lasa ◽  
Astrid Rausch ◽  
Luis Florez Bracho ◽  
Diego Berardi ◽  
Ignacio Zubiaurre
Keyword(s):  
Celiac Disease ◽  
Colorectal Adenomas ◽  
Adult Celiac Disease
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