Distensibility of the anal canal in patients with systemic sclerosis: a study with the functional lumen imaging probe

2012 ◽  
Vol 15 (1) ◽  
pp. e40-e47 ◽  
Author(s):  
L. Fynne ◽  
F. Luft ◽  
H. Gregersen ◽  
S. Buntzen ◽  
L. Lundby ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Anal Canal ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe

Esophagogastric junction in systemic sclerosis: A study with the functional lumen imaging probe

2017 ◽  
Vol 29 (8) ◽  
pp. e13073 ◽  
Author(s):  
L. Fynne ◽  
D. Liao ◽  
K. Aksglaede ◽  
C. Lottrup ◽  
H. Gregersen ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Esophagogastric Junction ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe

scholarly journals IDDF2018-ABS-0175 Functional lumen imaging probe assessment of anal canal distensibility

2018 ◽  
Author(s):  
Ssu Chi Chen ◽  
Kaori Futaba ◽  
Wing Wa Leung ◽  
Cherry Wong ◽  
Tony Mak ◽  
...  
Keyword(s):  
Anal Canal ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe

Estimation of mechanical work done to open the esophagogastric junction using functional lumen imaging probe panometry

2021 ◽  
Author(s):  
Shashank Acharya ◽  
Sourav Halder ◽  
Dustin A Carlson ◽  
Wenjun Kou ◽  
Peter J. Kahrilas ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Treatment Response ◽  
Eosinophilic Esophagitis ◽  
Esophagogastric Junction ◽  
Mechanical Work ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe ◽  
A Value ◽  
Work Done ◽  
The Relationship

Background: In this study, we quantify the work done by the esophagus to open the esophagogastric junction (EGJ) and create a passage for bolus flow into the stomach. Work done on the EGJ was computed using functional lumen imaging probe (FLIP) panometry. Methods: Eighty-five individuals underwent FLIP panometry with a 16 cm catheter during sedated endoscopy including asymptomatic controls (n=15), 45 achalasics (n=15 each, three subtypes), GERD (n=13), eosinophilic esophagitis (EoE; n=8) and systemic sclerosis (SSc; n=5). Luminal CSA and pressure were measured by the FLIP catheter positioned across the EGJ. Work done on the EGJ (EGJW) was computed (millijoules, mJ) at 40 mL distension. Additionally, a separate method was developed to estimate the "work required" to fully open the EGJ (EGJROW) when it did not open during the procedure. Results: EGJW for controls had a median (IQR) value of 75 (56-141) mJ. All achalasia subtypes showed low EGJW compared to controls (p<0.001). GERD and EoE subjects had EGJW 54.1 (6.9-96 .3) and 65.9 (10.8-102.3) mJ, similar to controls (p<0.08 and p<0.4, respectively). The scleroderma group showed low values of EGJW, 12 mJ (p<0.001). For achalasics, EGJROW was the greatest and had a value of 210.4 (115.2-375.4) mJ. Conclusions: Disease groups with minimal or absent EGJ opening showed low values of EGJW. For achalasics, EGJROW significantly exceeded EGJW values of all other groups highlighting its unique pathophysiology. Balancing the relationship between EGJW and EGJROW is potentially useful for calibrating achalasia treatments and evaluating treatment response.

Su1616 - Functional Lumen Imaging Probe (FLIP) to Perform Biofeedback and Strengthening of the Anal Canal Muscles

2018 ◽  
Vol 154 (6) ◽  
pp. S-549-S-550
Author(s):  
Lori Tuttle ◽  
David C. Kunkel ◽  
Ravinder K. Mittal
Keyword(s):  
Anal Canal ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe

Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies

Endoscopy ◽  
2017 ◽  
Vol 49 (09) ◽  
pp. 848-854 ◽  
Author(s):  
Peter Wu ◽  
Michal Szczesniak ◽  
Julia Maclean ◽  
Lennart Choo ◽  
Harry Quon ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Characteristic Curve ◽  
Diagnostic Tools ◽  
Cross Sectional ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe ◽  
Dysphagic Patients

Abstract Background and aims Chemoradiotherapy for head and neck cancer (HNC) with/without laryngectomy commonly causes dysphagia. Pharyngoesophageal junction (PEJ) stricturing is an important contributor. We aimed to validate a functional lumen imaging probe (the EndoFLIP system) as a tool for quantitating pretreatment PEJ distensibility and treatment-related changes in HNC survivors with dysphagia and to evaluate the diagnostic accuracy of EndoFLIP-derived distensibility in detecting PEJ strictures. Methods We studied 34 consecutive HNC survivors with long-term (> 12 months) dysphagia who underwent endoscopic dilation for suspected strictures. Twenty non-dysphagic patients undergoing routine endoscopy served as controls. PEJ distensibility was measured at endoscopy with the EndoFLIP system pre- and post-dilation. PEJ stricture was defined as the presence of a mucosal tear post-dilation. Results PEJ stricture was confirmed in 22/34 HNC patients (65 %). During distension up to 60 mmHg, the mean EndoFLIP-derived narrowest cross-sectional area (nCSA) in HNC patients with strictures, without strictures, and in controls were 58 mm2 (95 % confidence interval [CI] 22 to 118), 195 mm2 (95 %CI 129 to 334), and 227 mm2 (95 %CI 168 to 316), respectively. A cutoff of 114 mm2 for the nCSA at the PEJ had perfect diagnostic accuracy in detecting strictures (area under the receiver operating characteristic curve = 1). In patients with strictures, a single session of dilation increased the nCSA by 29 mm2 (95 %CI 20 to 37; P < 0.001). In patients with no strictures, dilation caused no change in the nCSA (mean difference 13 mm2 [95 %CI −4 to 30]; P = 0.13). Conclusions EndoFLIP is a highly accurate technique for the detection of PEJ strictures. EndoFLIP may complement conventional diagnostic tools in the detection of pharyngeal outflow obstruction.

Su1838 Esophageal Compliance Parameters Assessed With the Functional Lumen Imaging Probe (FLIP) Among Eosinophilic Esophagitis (EoE) Phenotypes

2013 ◽  
Vol 144 (5) ◽  
pp. S-487 ◽  
Author(s):  
Zhiyue Lin ◽  
Frédéric Nicodème ◽  
Joan Chen ◽  
Ikuo Hirano ◽  
Lubomyr Boris ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Imaging Probe ◽  
Functional Lumen Imaging Probe
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