Comparing ultrasound assessment of thyroid nodules using BTA U classification and ACR TIRADS measured against histopathological diagnosis

2021 ◽  
Author(s):  
Simon McClean ◽  
Eugene Omakobia ◽  
R. James A. England
Keyword(s):  
Thyroid Nodules ◽  
Histopathological Diagnosis ◽  
Ultrasound Assessment

Application of Thyroid Imaging Reporting and Data System in the Ultrasound Assessment of Thyroid Nodules According to Physician Experience

2016 ◽  
Vol 32 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Su Yeon Ko ◽  
Eun-Kyung Kim ◽  
Hee Jung Moon ◽  
Jung Hyun Yoon ◽  
Ha Yan Kim ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Data System ◽  
Thyroid Imaging ◽  
Ultrasound Assessment

Frequencies and malignancy rates of 6-tiered Bethesda categories of thyroid nodules according to ultrasound assessment and nodule size

Head & Neck ◽  
2018 ◽  
Vol 40 (9) ◽  
pp. 1947-1954 ◽  
Author(s):  
Vivian Youngjean Park ◽  
Hye Sun Lee ◽  
Eun-Kyung Kim ◽  
Jin Young Kwak ◽  
Jung Hyun Yoon ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Nodule Size ◽  
Ultrasound Assessment

BRAF V600E as an accurate marker to complement fine needle aspiration (FNA) cytology in the guidance of thyroid surgery in the Chinese population: evidence from over 1000 consecutive FNAs with follow-up

2020 ◽  
Author(s):  
Qunzi Zhao ◽  
Yong Wang ◽  
Qin Ye ◽  
Ping Wang ◽  
Jianyu Rao
Keyword(s):  
Fine Needle Aspiration ◽  
Thyroid Surgery ◽  
Chinese Population ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Histopathological Diagnosis ◽  
Fine Needle ◽  
Specificity And Sensitivity

Abstract Background Currently, several commercial molecular tests have been developed for reclassifying thyroid nodules with indeterminate fine needle aspiration cytology. These tests are quite expensive and not available in China. Previous studies demonstrated a very high prevalence of the BRAF V600E mutation in Asian people. A high incidence may result in a robust sensitivity. We conducted this study to determine the prevalence of BRAF V600E mutation and its ability to reclassify cytologically indeterminate thyroid nodules in the Chinese population. Methods Between January 2016 and October 2018, consecutive patients who underwent a fine needle aspiration procedure and agreed to provide materials for molecular analysis in our hospital were recruited in this study. All were followed up until they had a thyroidectomy and a final pathological diagnosis or until January 2019 (those did not have surgery). Results A total of 1960 patients were included in this study. Until January 2019, 1240 patients underwent surgery. Using histopathological diagnosis as a gold standard, the overall sensitivity and specificity of the BRAF V600E mutational analysis for the discrimination of benign nodules from cancer in thyroid fine needle aspiration samples were 83.3% (81.0–85.3%) and 96.0% (77.7–99.8%), respectively, with an area under the ROC curve of 0.90 (95% CI 0.85–0.95, P < 0.001). Among cases with indeterminate cytology, BRAF-positive cases were showing malignancy in the final pathology, and BRAF-negative cases were showing safer to be followed up. Conclusion The BRAF V600E mutation is highly prevalent in the Chinese population and can accurately complement cytopathology in the guidance of thyroid surgery. Mini-abstract: The BRAF V600E mutation has both high specificity and sensitivity to predict thyroid malignancy in the Chinese population. It can accurately complement cytopathology in the guidance of thyroid surgery.

scholarly journals Ultrasound Assessment of Autonomous Thyroid Nodules before and after Radioiodine Therapy Using Thyroid Imaging Reporting and Data System (TIRADS)

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1038
Author(s):  
Simone Agnes Schenke ◽  
Jan Wuestemann ◽  
Michael Zimny ◽  
Michael Christoph Kreissl
Keyword(s):  
High Risk ◽  
Thyroid Nodules ◽  
Radioiodine Therapy ◽  
Diagnostic Procedures ◽  
Low Risk ◽  
Therapeutic Interventions ◽  
Thyroid Imaging ◽  
Before And After ◽  
Autonomously Functioning Thyroid Nodules ◽  
Ultrasound Assessment

The Thyroid Imaging and Reporting System (TIRADS) allows a sonographic assessment of the malignancy risk of thyroid nodules (TNs). To date, there is a lack of systematic data about the change in ultrasound (US) features after therapeutic interventions. The aim of this study was to characterize the changes in autonomously functioning thyroid nodules (AFTNs) after radioiodine therapy (RIT) by using TIRADS. We retrospectively assessed data from 68 patients with AFTNs treated with RIT between 2016 and 2018 who had available first and second follow-up US imaging. Before RIT, 69.1% of the AFTNs were classified as low-risk TNs when applying Kwak TIRADS (EU-TIRADS 52.9%), 22.1% were intermediate-risk TNs (EU-TIRADS 19.1%), and 8.8% were high-risk TNs (EU-TIRADS 27.9%). Twelve months after RIT, 22.1% of the AFTNs showed features of high-risk TNs according to Kwak TIRADS (EU-TIRADS 45.6%). The proportion of intermediate TNs also increased to 36.8% (EU-TIRADS 29.4%), and 41.2% were low-risk TNs (EU-TIRADS 25%). A significant percentage of AFTNs presented with features suspicious for malignancy according to TIRADS before RIT, and this number increased significantly after therapy. Therefore, before thyroid US, thorough anamnesis regarding prior radioiodine treatment is necessary to prevent unneeded diagnostic procedures.

scholarly journals Comparison of surgeon-performed ultrasound-guided fine needle aspiration cytology with histopathological diagnosis of thyroid nodules

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Muhammad Ayoob Jat
Keyword(s):  
Thyroid Nodule ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Solitary Thyroid Nodule ◽  
Needle Aspiration Cytology

Objective: To assess the Solitary thyroid nodules by surgeon-performed ultrasound-guided FNAC and evaluate with the histopathological findings. Methods: This study includes 100 Consecutive patients of a solitary thyroid nodule which were presented to the Outpatients Department of Surgery during the period of two years from September 2016 to August 2018. Exclusion criteria were patients with extra-thyroid swelling, diffuse goiter and multinodular goiter. All patients with a solitary thyroid nodule underwent Surgeon –performed ultrasound-guided FNAC in the department of Radiology. After thyroid surgery, thyroid specimens were sent for histopathology and evaluate with FNAC findings. Results: The study included hundred patients with solitary thyroid nodule, 75(75%) female and 25 (25%) male with a ratio of F 3:1M. The age of the patients ranged from 15-75 years with a mean age of 35 years. The result of 100 cases of Surgeon –performed Ultrasound –guide FNAC of a solitary thyroid nodule were inconclusive in 10 cases (10%), Non-neoplastic in 60 cases (60%) and Neoplastic lesions in 30 cases (30%). After evaluation of findings from FNAC and histopathology, four cases with benign FNAC (adenomatous/colloid Goiter) turnout as neoplastic (papillary carcinoma) on histopathology and six cases with neoplastic FNAC (papillary carcinoma), just two cases turnout as benign (nodular colloid goiter with cystic degeneration) on histopathology. In present study Surgeon – performed Us FNAC has found to be 87.5% sensitive, 95.3% specific and 92.0% diagnostic accuracy. Conclusion: Surgeon – performed Ultrasound-guided FNAC is a safe, simple and accurate technique in the diagnosis of solitary thyroid nodule. doi: https://doi.org/10.12669/pjms.35.4.537 How to cite this:Jat MA. Comparison of surgeon-performed ultrasound-guided fine needle aspiration cytology with histopathological diagnosis of thyroid nodules. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.537 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals CYTO-HISTOPATHOLOGICAL CORRELATION OF THYROID LESIONS

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Dharmendra Singh Bhadouria ◽  
Shikha Raghuwanshi ◽  
Arun Saxena
Keyword(s):  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Patient Acceptance ◽  
Histopathological Diagnosis ◽  
Thyroid Lesion ◽  
Follicular Hyperplasia ◽  
Neoplastic Lesion ◽  
Thyroid Lesions

Introduction: Thyroid nodules show an overall incidence rate of 4-7% & high probability of malignancy, constituting 5% to 35%. FNAC of Thyroid is most economical and reliable preoperative procedure to distinguish between neoplastic and non- neoplastic lesion. Objectives: To Study Cyto-Morphology of Fine Needle Aspiration of Thyroid nodules. To find out incidence of various types of lesions as per age & sex and to confirm the findings with Histomorphological diagnosis of same nodule. Material & Methods: 100 patients with Thyroid nodule who underwent FNAC & Thyroidectomy taken for an observational study from January 2019 to June 2020. The cytological findings were correlated with histopathological diagnosis. Results: Out of 100 cases 14 cases were  found to be malignant and 86 were found to be benign on histology while cytology showed 93 cases benign and 7  malignant cases .Out of 5 cases suspicious for neoplasm and 3 cases were of follicular neoplasm on cytology which confirmed as papillary carcinoma on histopathology.2 cases which were diagnosed as Benign Thyroid lesion turned out to be papillary carcinoma and 2 cases which were diagnosed as colloid goitre on cytology turned out to be papillary carcinoma on histo pathology .1 case diagnosed as follicular hyperplasia turned out to be papillary carcinoma on histology.1 case diagnosed as MNG in cytology was turned out to be papillary carcinoma on histo pathology. Conclusion: Thyroid cytology proves to be a reliable, simple and cost-effective first line diagnostic procedure with high patient acceptance and without complications. FNAC serves as useful screening test for thyroid lesions. However, inability in distinguishing follicular lesion and inadequate sampling in cystic lesion lead to false diagnosis. Keywords: Histopathology, Thyroid , Lesion.

scholarly journals Elastography for the evaluation of thyroid nodules in pediatric patients

2019 ◽  
Vol 52 (3) ◽  
pp. 141-147 ◽  
Author(s):  
Gustavo Bittar Cunha ◽  
Luciana Cristante Izar Marino ◽  
André Yamaya ◽  
Cristiane Kochi ◽  
Osmar Monte ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Pediatric Patients ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Manual Compression ◽  
Fine Needle ◽  
High Elasticity ◽  
A Prospective Study

Abstract Objective: To evaluate the usefulness of elastography (using manual compression) as an additional diagnostic tool for children and adolescents with thyroid nodules. Materials and Methods: This was a prospective study conducted between September 2012 and August 2013 at a hospital in Brazil. We performed elastography, ultrasound, and fine-needle aspiration biopsy in 32 patients between 6 and 18 years of age who had, in total, 38 thyroid nodules. Results: The elastography findings correlated with the histopathological diagnosis in 78.5% of cases. In three patients, an unnecessary thyroidectomy could have been avoided if the elastography results had been prioritized. Only one malignant thyroid nodule was found to show high elasticity. Conclusion: Our results suggest that high elasticity of a nodule on elastography is associated with a low risk of thyroid cancer. If further confirmed in other studies, elastography may prove useful as a complementary test for screening thyroid nodules in children.

scholarly journals Incidence, Clinical Characteristics, and Histopathological Results of Atypia of Undermined Significance in a Tertiary Center in UAE

2021 ◽  
Vol 27 (1) ◽  
pp. 1-5
Author(s):  
Maha Osman Shangab ◽  
Azza Abdulaziz Khalifa ◽  
Fatheya Al Awadi ◽  
Mouza Alsharhan ◽  
Alaaeldin Bashier
Keyword(s):  
Thyroid Nodules ◽  
Histopathological Diagnosis ◽  
Class Iii ◽  
Tertiary Center ◽  
Risk Of Malignancy ◽  
Estimated Risk ◽  
Time Gap ◽  
Histopathological Results ◽  
Common Malignancy

<b><i>Introduction:</i></b> Bethesda classification of thyroid nodules cytology is an agreed upon method of classifying thyroid nodules according to risk of malignancy. Among them, Bethesda class III (Atypia of Undetermined Significance, AUS) has been a topic of great controversy. The reported estimated risk of malignancy associated with it varies in different studies. Our study investigates the associated incidence of malignancy in a single tertiary center in UAE. <b><i>Methodology:</i></b> Data were retrospectively collected over a 10-year period from January 2009 till December 2018 for cytology diagnosis of AUS. Patient charts were reviewed for method of management. Surgical and histopathology records were reviewed to compare findings on cytology versus histopathology. <b><i>Results:</i></b> A total of 180 cases were diagnosed Bethesda III (AUS) with a mean age of 45.09 ± 14.7 years. One hundred cases (55.6%) of them underwent surgical resection, and histopathological diagnosis was obtained. Among the operated cases, 46 were benign and 54 were malignant. Papillary thyroid cancer was the most common malignancy, seen in 39 (72.2%) of cases, and follicular cancer was the second most common, seen in 13 (24.1%) cases. <b><i>Conclusion:</i></b> The findings highlighted in our study suggest a higher incidence of malignancy in Bethesda III category than previously reported. It also puts in question the utility and benefit behind keeping a time gap and repeating FNA as previously recommended.

Interobserver and Intraobserver Variations in Ultrasound Assessment of Thyroid Nodules

Thyroid ◽  
2010 ◽  
Vol 20 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Seon Hyeong Choi ◽  
Eun-Kyung Kim ◽  
Jin Young Kwak ◽  
Min Jung Kim ◽  
Eun Ju Son
Keyword(s):  
Thyroid Nodules ◽  
Ultrasound Assessment
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