Pre-treatment CD8+ tumour-infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

2018 ◽  
Vol 43 (5) ◽  
pp. 1312-1320 ◽  
Author(s):  
T. Ono ◽  
K. Azuma ◽  
A. Kawahara ◽  
J. Akiba ◽  
T. Kakuma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Distant Metastasis ◽  
Stage Iii ◽  
Definitive Treatment ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Pre Treatment

scholarly journals Matted nodes as a predictor of distant metastasis in advanced-stage III/IV oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Matthew E. Spector ◽  
Steven B. Chinn ◽  
Emily Bellile ◽  
K. Kelly Gallagher ◽  
Mohannad Ibrahim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Distant Metastasis ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Stage Iii ◽  
Advanced Stage

Relevance between PD-L1 expression combined with tumor infiltrating lymphocytes and prognosis in advanced hypopharyngeal squamous cell carcinoma.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17528-e17528
Author(s):  
Takeharu Ono ◽  
Koichi Azuma ◽  
Akihiko Kawahara ◽  
Tetsuro Sasada ◽  
Satoshi Hattori ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Subgroup Analysis ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
Immunohistochemical Analysis ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

e17528 Background: Little information has been available regarding immune-related prognostic factors in patients with advanced hypopharyngeal squamous cell carcinoma (HPSCC). Expression of programmed cell death-ligand 1 (PD-L1) in tumor cells is known to be a mechanism whereby cancer can escape immune surveillance. We investigated the predictive relevance of PD-L1 expression in tumor cells and tumor-infiltrating lymphocyte (TIL) density in patients with locally advanced HPSCC receiving neoadjuvant chemotherapy (NAC). Methods: We retrospectively reviewed 83 consecutive patients with advanced HPSCC who had received NAC. PD-L1 expression and TIL density were evaluated by immunohistochemical analysis. Results: Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for progression free survival (PFS) and overall survival (OS), whereas PD-L1 expression was not correlated with PFS or OS. Subgroup analysis defined by PD-L1 expression in combination with CD8+ TIL density revealed that the PD-L1-/CD8high group showed the longest survival (median PFS and OS were not reached), whereas the PD-L1+/CD8low group showed the shortest PFS (median 7.9 months, p = 0.006) and OS (14.3 months, p = 0.011) by Kaplan-Meier curves. Conclusions: Although there was no significant correlation between PD-L1 expression and prognosis in stage III and IV HPSCC patients who received NAC, the subgroup analysis indicated that combination of lack of PD-L1 expression and higher CD8+ TIL density was significantly associated with favorable survival in these patients. These results suggested that PD-L1 expression levels in combination with CD8+ TIL density could be a useful predictive biomarker in patients with stage III and IV HPSCC.

CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
Vol 37 (11) ◽  
pp. 1569-1574 ◽  
Author(s):  
Miroru Toyoda ◽  
Kyoichi Kaira ◽  
Masato Shino ◽  
Koichi Sakakura ◽  
Katsumasa Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Indicator ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

scholarly journals Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma

Neoplasma ◽  
2016 ◽  
Vol 63 (03) ◽  
pp. 477-483 ◽  
Author(s):  
K. KAIRA ◽  
M. TOYODA ◽  
A. SHIMIZU ◽  
H. IMAI ◽  
K. Sakakura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

scholarly journals The selection of treatment strategy for stage III, IV laryngeal and hypopharyngeal squamous cell carcinoma

2016 ◽  
Vol 25 (3) ◽  
pp. 275-282
Author(s):  
Takeshi Beppu ◽  
Takao Tokumaru ◽  
Taro Fujikawa ◽  
Wataru Okano ◽  
Masato Yamada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Strategy ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Selection Of

Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study.

1988 ◽  
Vol 6 (4) ◽  
pp. 627-632 ◽  
Author(s):  
M Merlano ◽  
R Rosso ◽  
M R Sertoli ◽  
L Bonelli ◽  
G Margarino ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Randomized Study ◽  
Stage Iv ◽  
Phase Iii ◽  
Stage Iii ◽  
Definitive Treatment ◽  
Response Analysis

A cooperative randomized study was begun in August 1983 to compare a sequential program of induction chemotherapy followed by definitive treatment, arm A, with an alternation of chemotherapy and radiotherapy (three courses of 20 Gy in ten daily fractions), arm B. The same chemotherapy was used in both arms: 6 mg/m2, vinblastine, hour 0; 30 mg, bleomycin, hour 6; 200 mg, methotrexate, hours 24 to 26; 45 mg, leucovorin, hour 48. One hundred sixteen patients entered the study, 55 in arm A and 61 in arm B. The patients all had previously untreated squamous cell carcinoma of the head and neck (SCCHN). Forty-five patients had stage III and 71 had stage IV disease. The two arms were fully comparable. As of April 1986, 116 patients were evaluable for survival, while 112 were evaluable for toxicity and 105 for response. Response analysis shows that there were 14 complete responses (CR) and 11 partial responses (PR), for an overall response rate (ORR) of 52% in arm A, and 30 CRs and seven PRs, for an ORR of 64.9% in arm B. The difference in terms of CR between the two arms was statistically significant (P less than .03). Progression-free survival (PFS) was also statistically different, with an advantage for arm B (P less than .05), but without differences in overall survival. Arm B correlates with a significant increase in mucositis compared with arm A (P less than .001).

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