CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
Vol 37 (11) ◽  
pp. 1569-1574 ◽  
Author(s):  
Miroru Toyoda ◽  
Kyoichi Kaira ◽  
Masato Shino ◽  
Koichi Sakakura ◽  
Katsumasa Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Indicator ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

Relevance between PD-L1 expression combined with tumor infiltrating lymphocytes and prognosis in advanced hypopharyngeal squamous cell carcinoma.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17528-e17528
Author(s):  
Takeharu Ono ◽  
Koichi Azuma ◽  
Akihiko Kawahara ◽  
Tetsuro Sasada ◽  
Satoshi Hattori ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Subgroup Analysis ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
Immunohistochemical Analysis ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

e17528 Background: Little information has been available regarding immune-related prognostic factors in patients with advanced hypopharyngeal squamous cell carcinoma (HPSCC). Expression of programmed cell death-ligand 1 (PD-L1) in tumor cells is known to be a mechanism whereby cancer can escape immune surveillance. We investigated the predictive relevance of PD-L1 expression in tumor cells and tumor-infiltrating lymphocyte (TIL) density in patients with locally advanced HPSCC receiving neoadjuvant chemotherapy (NAC). Methods: We retrospectively reviewed 83 consecutive patients with advanced HPSCC who had received NAC. PD-L1 expression and TIL density were evaluated by immunohistochemical analysis. Results: Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for progression free survival (PFS) and overall survival (OS), whereas PD-L1 expression was not correlated with PFS or OS. Subgroup analysis defined by PD-L1 expression in combination with CD8+ TIL density revealed that the PD-L1-/CD8high group showed the longest survival (median PFS and OS were not reached), whereas the PD-L1+/CD8low group showed the shortest PFS (median 7.9 months, p = 0.006) and OS (14.3 months, p = 0.011) by Kaplan-Meier curves. Conclusions: Although there was no significant correlation between PD-L1 expression and prognosis in stage III and IV HPSCC patients who received NAC, the subgroup analysis indicated that combination of lack of PD-L1 expression and higher CD8+ TIL density was significantly associated with favorable survival in these patients. These results suggested that PD-L1 expression levels in combination with CD8+ TIL density could be a useful predictive biomarker in patients with stage III and IV HPSCC.

scholarly journals Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma

Neoplasma ◽  
2016 ◽  
Vol 63 (03) ◽  
pp. 477-483 ◽  
Author(s):  
K. KAIRA ◽  
M. TOYODA ◽  
A. SHIMIZU ◽  
H. IMAI ◽  
K. Sakakura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma

scholarly journals The selection of treatment strategy for stage III, IV laryngeal and hypopharyngeal squamous cell carcinoma

2016 ◽  
Vol 25 (3) ◽  
pp. 275-282
Author(s):  
Takeshi Beppu ◽  
Takao Tokumaru ◽  
Taro Fujikawa ◽  
Wataru Okano ◽  
Masato Yamada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Strategy ◽  
Stage Iii ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Selection Of
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