scholarly journals Zinc provides neuroprotection by regulating NLRP3 inflammasome through autophagy and ubiquitination in a spinal contusion injury model

2020 ◽  
Author(s):  
Jia‐quan Lin ◽  
He Tian ◽  
Xiao‐guang Zhao ◽  
Sen Lin ◽  
Dao‐yong Li ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Injury Model ◽  
Contusion Injury ◽  
Spinal Contusion

A Cervical Spinal Cord Hemi-Contusion Injury Model Based on Displacement Control in Non-Human Primates (Macaca fascicularis)

2020 ◽  
Vol 37 (15) ◽  
pp. 1669-1686
Author(s):  
Junhao Liu ◽  
Rong Li ◽  
Zucheng Huang ◽  
Zhiping Huang ◽  
Yuefeng Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Macaca Fascicularis ◽  
Cervical Spinal Cord ◽  
Displacement Control ◽  
Model Based ◽  
Injury Model ◽  
Contusion Injury

Examining the effects of pain on morphine self-administration following a spinal contusion injury

2013 ◽  
Vol 14 (4) ◽  
pp. S51
Author(s):  
S. Woller ◽  
J. Malik ◽  
M. Aceves ◽  
P. Wellman ◽  
M. Hook
Keyword(s):  
Self Administration ◽  
Contusion Injury ◽  
Spinal Contusion

scholarly journals Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury

2012 ◽  
Vol 235 (1) ◽  
pp. 174-187 ◽  
Author(s):  
Ellen M. Andrews ◽  
Rebekah J. Richards ◽  
Feng Q. Yin ◽  
Mariano S. Viapiano ◽  
Lyn B. Jakeman
Keyword(s):  
Chondroitin Sulfate ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Contusion Injury ◽  
Spinal Contusion

scholarly journals Spinal Cord Injury Causes Reduction of Galanin and Gastrin Releasing Peptide mRNA Expression in the Spinal Ejaculation Generator of Male Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
James W. Wiggins ◽  
Jonathan E. Sledd ◽  
Lique M. Coolen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Male Rats ◽  
Lumbar Spinal Cord ◽  
Gastrin Releasing Peptide ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Contusion ◽  
Lumbar Spinal ◽  
Injury Causes

Spinal cord injury (SCI) in men is commonly associated with sexual dysfunction, including anejaculation, and chronic mid-thoracic contusion injury in male rats also impairs ejaculatory reflexes. Ejaculation is controlled by a spinal ejaculation generator consisting of a population of lumbar spinothalamic (LSt) neurons that control ejaculation through release of four neuropeptides including galanin and gastrin releasing peptide (GRP) onto lumbar and sacral autonomic and motor nuclei. It was recently demonstrated that spinal contusion injury in male rats caused reduction of GRP-immunoreactivity, but not galanin-immunoreactivity in LSt cells, indicative of reduced GRP peptide levels, but inconclusive results for galanin. The current study further tests the hypothesis that contusion injury causes a disruption of GRP and galanin mRNA in LSt cells. Male rats received mid-thoracic contusion injury and galanin and GRP mRNA were visualized 8 weeks later in the lumbar spinal cord using fluorescent in situ hybridization. Spinal cord injury significantly reduced GRP and galanin mRNA in LSt cells. Galanin expression was higher in LSt cells compared to GRP. However, expression of the two transcripts were positively correlated in LSt cells in both sham and SCI animals, suggesting that expression for the two neuropeptides may be co-regulated. Immunofluorescent visualization of galanin and GRP peptides demonstrated a significant reduction in GRP-immunoreactivity, but not galanin in LSt cells, confirming the previous observations. In conclusion, SCI reduced GRP and galanin expression in LSt cells with an apparent greater impact on GRP peptide levels. GRP and galanin are both essential for triggering ejaculation and thus such reduction may contribute to ejaculatory dysfunction following SCI in rats.

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