Transplantation of Undifferentiated and Induced Human Exfoliated Deciduous Teeth-Derived Stem Cells Promote Functional Recovery of Rat Spinal Cord Contusion Injury Model

2012 ◽  
Vol 21 (10) ◽  
pp. 1794-1802 ◽  
Author(s):  
Zahra Taghipour ◽  
Khadijeh Karbalaie ◽  
Abbas Kiani ◽  
Ali Niapour ◽  
Hamid Bahramian ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Functional Recovery ◽  
Deciduous Teeth ◽  
Rat Spinal Cord ◽  
Injury Model ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Human Exfoliated Deciduous Teeth

Stem Cells from Human Exfoliated Deciduous Teeth Modulate Early Astrocyte Response after Spinal Cord Contusion

2018 ◽  
Vol 56 (1) ◽  
pp. 748-760 ◽  
Author(s):  
Fabrício Nicola ◽  
Marília Rossato Marques ◽  
Felipe Odorcyk ◽  
Letícia Petenuzzo ◽  
Dirceu Aristimunha ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Deciduous Teeth ◽  
Spinal Cord Contusion ◽  
Human Exfoliated Deciduous Teeth

Co-expression of radial glial marker in macrophages/microglia in rat spinal cord contusion injury model

2005 ◽  
Vol 1051 (1-2) ◽  
pp. 183-188 ◽  
Author(s):  
Di Wu ◽  
Osamu Miyamoto ◽  
Sei Shibuya ◽  
Satoshi Mori ◽  
Hiromichi Norimatsu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Injury Model ◽  
Contusion Injury ◽  
Radial Glial ◽  
Spinal Cord Contusion ◽  
Glial Marker

scholarly journals Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tamás Bellák ◽  
Zoltán Fekécs ◽  
Dénes Török ◽  
Zsuzsanna Táncos ◽  
Csilla Nemes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Pluripotent Stem Cells ◽  
Functional Improvement ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Induced Pluripotent

AbstractSpinal cord injury results in irreversible tissue damage followed by a very limited recovery of function. In this study we investigated whether transplantation of undifferentiated human induced pluripotent stem cells (hiPSCs) into the injured rat spinal cord is able to induce morphological and functional improvement. hiPSCs were grafted intraspinally or intravenously one week after a thoracic (T11) spinal cord contusion injury performed in Fischer 344 rats. Grafted animals showed significantly better functional recovery than the control rats which received only contusion injury. Morphologically, the contusion cavity was significantly smaller, and the amount of spared tissue was significantly greater in grafted animals than in controls. Retrograde tracing studies showed a statistically significant increase in the number of FB-labeled neurons in different segments of the spinal cord, the brainstem and the sensorimotor cortex. The extent of functional improvement was inversely related to the amount of chondroitin-sulphate around the cavity and the astrocytic and microglial reactions in the injured segment. The grafts produced GDNF, IL-10 and MIP1-alpha for at least one week. These data suggest that grafted undifferentiated hiPSCs are able to induce morphological and functional recovery after spinal cord contusion injury.

scholarly journals Correction to: Stem Cells from Human Exfoliated Deciduous Teeth Modulate Early Astrocyte Response after Spinal Cord Contusion

2018 ◽  
Vol 56 (1) ◽  
pp. 761-762 ◽  
Author(s):  
Fabrício Nicola ◽  
Marília Rossato Marques ◽  
Felipe Odorcyk ◽  
Letícia Petenuzzo ◽  
Dirceu Aristimunha ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Deciduous Teeth ◽  
Spinal Cord Contusion ◽  
Human Exfoliated Deciduous Teeth

Expression and role of type I collagen in a rat spinal cord contusion injury model

2007 ◽  
Vol 58 (4) ◽  
pp. 371-377 ◽  
Author(s):  
Maiko Okada ◽  
Osamu Miyamoto ◽  
Sei Shibuya ◽  
Xia Zhang ◽  
Tetsuji Yamamoto ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Type I Collagen ◽  
Type I ◽  
Rat Spinal Cord ◽  
Injury Model ◽  
Contusion Injury ◽  
Spinal Cord Contusion

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury

Cytotherapy ◽  
2010 ◽  
Vol 12 (3) ◽  
pp. 313-325 ◽  
Author(s):  
Siobhan S. McMahon ◽  
Silke Albermann ◽  
Gemma E. Rooney ◽  
Georgina Shaw ◽  
Yolanda Garcia ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Rat Spinal Cord ◽  
Contusion Injury
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