scholarly journals The novel atypical antipsychotic cariprazine demonstrates dopamine D2receptor‐dependent partial agonist actions on rat mesencephalic dopamine neuronal activity

2018 ◽  
Vol 24 (12) ◽  
pp. 1129-1139 ◽  
Author(s):  
Sarah Delcourte ◽  
Charles R. Ashby ◽  
Renaud Rovera ◽  
Béla Kiss ◽  
Nika Adham ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Neuronal Activity ◽  
Partial Agonist ◽  
The Novel ◽  
Mesencephalic Dopamine

The Novel Ins(1,4,5)P3 Analog 3-Amino-3-deoxy-Ins(1,4,5)P3: A pH-Dependent Ins(1,4,5)P3 Receptor Partial Agonist in SH-SY5Y Neuroblastoma Cells

1994 ◽  
Vol 37 (6) ◽  
pp. 868-872 ◽  
Author(s):  
Alan P. Kozikowski ◽  
Abdul H. Fauq ◽  
Robert A. Wilcox ◽  
R. A. John Challiss ◽  
Stefan R. Nahorski
Keyword(s):  
Partial Agonist ◽  
Neuroblastoma Cells ◽  
The Novel ◽  
Ph Dependent

P.3.c.047 Pharmacokinetics of RGH-188, a new dopamine D3/D2 antagonist/partial agonist atypical antipsychotic, in healthy subjects

2007 ◽  
Vol 17 ◽  
pp. S451-S452 ◽  
Author(s):  
G. P´asztor M´esz´aros ◽  
M. Kap´as ◽  
M. Borsos ◽  
I. Laszlovszky ◽  
G. N´emeth ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Healthy Subjects ◽  
Partial Agonist ◽  
D2 Antagonist ◽  
Dopamine D3

P.3.d.015 Pharmacokinetics of RGH-188, a novel dopamine D3/D2 antagonist/partial agonist atypical antipsychotic, in rats and dogs

2008 ◽  
Vol 18 ◽  
pp. S456-S457 ◽  
Author(s):  
G. Pásztor Mészáros ◽  
E. Terjéki Bolf ◽  
L. Gémesi ◽  
M. Kapáas ◽  
K. Tihanyi ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Partial Agonist ◽  
D2 Antagonist ◽  
Dopamine D3

scholarly journals The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yvonne Connolly Martin
Keyword(s):  
Medicinal Chemistry ◽  
Partial Agonist ◽  
Skf 38393 ◽  
The Novel ◽  
Bioactive Conformation ◽  
Dopaminergic Agonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
A 68930

The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity to a screening hit, and by traditional medicinal chemistry exploration of structure-activity relationships. The subsequent design of A-86929 and ABT-413 capitalized on these results, recently disclosed agonists, and traditional medicinal chemistry.

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