The Novel Ins(1,4,5)P3 Analog 3-Amino-3-deoxy-Ins(1,4,5)P3: A pH-Dependent Ins(1,4,5)P3 Receptor Partial Agonist in SH-SY5Y Neuroblastoma Cells

1994 ◽  
Vol 37 (6) ◽  
pp. 868-872 ◽  
Author(s):  
Alan P. Kozikowski ◽  
Abdul H. Fauq ◽  
Robert A. Wilcox ◽  
R. A. John Challiss ◽  
Stefan R. Nahorski
Keyword(s):  
Partial Agonist ◽  
Neuroblastoma Cells ◽  
The Novel ◽  
Ph Dependent

scholarly journals Self-Assembled Metal–Organic Biohybrids (MOBs) Using Copper and Silver for Cell Studies

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1282 ◽  
Author(s):  
Neha Karekar ◽  
Anik Karan ◽  
Elnaz Khezerlou ◽  
Neela Prajapati ◽  
Chelsea D. Pernici ◽  
...  
Keyword(s):  
Self Assembly ◽  
Neuroblastoma Cells ◽  
The Novel ◽  
Culture Methods ◽  
Synthesis Conditions ◽  
Tissue Constructs ◽  
Silver Sulfate ◽  
Significant Toxicity ◽  
Metal Organic

The novel synthesis of metal-containing biohybrids using self-assembly methods at physiological temperatures (37 °C) was compared for copper and silver using the amino acid dimer cystine. Once assembled, the copper containing biohybrid is a stable, high-aspect ratio structure, which we call CuHARS. Using the same synthesis conditions, but replacing copper with silver, we have synthesized cystine-capped silver nanoparticles (AgCysNPs), which are shown here to form stable colloid solutions in contrast to the CuHARS, which settle out from a 1 mg/mL solution in 90 min. Both the copper and silver biohybrids, as synthesized, demonstrate very low agglomeration which we have applied for the purpose of applications with cell culture methods, namely, for testing as anti-cancer compounds. AgCysNPs (1000 ng/mL) demonstrated significant toxicity (only 6.8% viability) to glioma and neuroblastoma cells in vitro, with concentrations as low as 20 ng/mL causing some toxicity. In contrast, CuHARS required at least 5 μg/mL. For comparative purposes, silver sulfate at 100 ng/mL decreased viability by 52% and copper sulfate at 100 ng/mL only by 19.5% on glioma cells. Using these methods, the novel materials were tested here as metal–organic biohybrids (MOBs), and it is anticipated that the functionalization and dynamics of MOBs may result in building a foundation of new materials for cellular applications, including cell engineering of both normal and diseased cells and tissue constructs.

scholarly journals Synthesis of the novel (±)-2-methoxy-6-icosynoic acid—A fatty acid that induces death of neuroblastoma cells

2013 ◽  
Vol 172-173 ◽  
pp. 14-19 ◽  
Author(s):  
Elsie A. Orellano ◽  
Michelle M. Cartagena ◽  
Karolyna Rosado ◽  
Néstor M. Carballeira
Keyword(s):  
Fatty Acid ◽  
Neuroblastoma Cells ◽  
The Novel

scholarly journals The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yvonne Connolly Martin
Keyword(s):  
Medicinal Chemistry ◽  
Partial Agonist ◽  
Skf 38393 ◽  
The Novel ◽  
Bioactive Conformation ◽  
Dopaminergic Agonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
A 68930

The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity to a screening hit, and by traditional medicinal chemistry exploration of structure-activity relationships. The subsequent design of A-86929 and ABT-413 capitalized on these results, recently disclosed agonists, and traditional medicinal chemistry.

scholarly journals The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells

2011 ◽  
Vol 10 (12) ◽  
pp. 2373-2383 ◽  
Author(s):  
Tetyana Klymenko ◽  
Martin Brandenburg ◽  
Christopher Morrow ◽  
Caroline Dive ◽  
Guy Makin
Keyword(s):  
Drug Resistance ◽  
Neuroblastoma Cells ◽  
The Novel

The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism

2007 ◽  
Vol 73 (5) ◽  
pp. 643-655 ◽  
Author(s):  
Angela Maria Di Francesco ◽  
Daniela Meco ◽  
Anna Rita Torella ◽  
Giuseppe Barone ◽  
Maurizio D’Incalci ◽  
...  
Keyword(s):  
Neuroblastoma Cells ◽  
The Novel
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