scholarly journals Aquaporin-4 Deficiency Attenuates Opioid Dependence through Suppressing Glutamate Transporter-1 Down-regulation and Maintaining Glutamate Homeostasis

2012 ◽  
Vol 19 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Hai-Tao Yan ◽  
Ning Wu ◽  
Xin-Qiang Lu ◽  
Rui-Bin Su ◽  
Jian-Quan Zheng ◽  
...  
Keyword(s):  
Opioid Dependence ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Down Regulation ◽  
Glutamate Homeostasis ◽  
Glutamate Transporter 1

Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke

2014 ◽  
Vol 127 (12) ◽  
pp. 679-689 ◽  
Author(s):  
Zhong-Bao Yang ◽  
Zhen Zhang ◽  
Ting-Bo Li ◽  
Zheng Lou ◽  
Shu-Yu Li ◽  
...  
Keyword(s):  
Plasma Level ◽  
Ischaemic Stroke ◽  
Glutamate Transporter ◽  
Down Regulation ◽  
Diagnosis And Prognosis ◽  
Glutamate Transporter 1

Elevated miR-107 expression after ischaemic stroke accounts for glutamate accumulation through the suppression of glutamate transporter-1 expression. The plasma level of miR-107 may serve as a novel biomarker for diagnosis and prognosis of ischaemic stroke.

scholarly journals The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yu-Long Lan ◽  
Shuang Zou ◽  
Jian-Jiao Chen ◽  
Jie Zhao ◽  
Shao Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Ion Homeostasis ◽  
Water Channel ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Normal Brain ◽  
Glutamate Transporter 1

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by memory loss and cognitive dysfunction. Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS). This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions. Emerging evidence suggests that AQP4 deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1). Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. The association of AQP4 and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.

scholarly journals Different Dynamics of Aquaporin 4 and Glutamate Transporter-1 Distribution in the Perineuronal and Perivascular Compartments during Ischemic Stroke

2014 ◽  
Vol 24 (5) ◽  
pp. 475-493 ◽  
Author(s):  
Laurentiu Mogoanta ◽  
Marius Ciurea ◽  
Ionica Pirici ◽  
Claudiu Margaritescu ◽  
Cristiana Simionescu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Glutamate Transporter 1

scholarly journals Unaltered Glutamate Transporter-1 Protein Levels in Aquaporin-4 Knockout Mice

ASN NEURO ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 175909141668784
Author(s):  
Jacqueline A. Hubbard ◽  
Devin K. Binder
Keyword(s):  
Knockout Mice ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Protein Levels ◽  
Glutamate Transporter 1

scholarly journals Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

2016 ◽  
Vol 283 ◽  
pp. 85-96 ◽  
Author(s):  
Jacqueline A. Hubbard ◽  
Jenny I. Szu ◽  
Jennifer M. Yonan ◽  
Devin K. Binder
Keyword(s):  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Aqp4 Expression ◽  
Glutamate Transporter 1
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