Altered expression of glutamate transporter-1 and water channel protein aquaporin-4 in human temporal cortex with Alzheimer's disease

2018 ◽  
Vol 44 (6) ◽  
pp. 628-638 ◽  
Author(s):  
A. Hoshi ◽  
A. Tsunoda ◽  
T. Yamamoto ◽  
M. Tada ◽  
A. Kakita ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Water Channel ◽  
Temporal Cortex ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Altered Expression ◽  
Channel Protein ◽  
Glutamate Transporter 1 ◽  
Water Channel Protein

scholarly journals The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yu-Long Lan ◽  
Shuang Zou ◽  
Jian-Jiao Chen ◽  
Jie Zhao ◽  
Shao Li
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Ion Homeostasis ◽  
Water Channel ◽  
Glutamate Transporter ◽  
Aquaporin 4 ◽  
Normal Brain ◽  
Glutamate Transporter 1

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by memory loss and cognitive dysfunction. Aquaporin-4 (AQP4), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS). This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions. Emerging evidence suggests that AQP4 deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1). Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. Here, we review the interaction of AQP4 and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. The association of AQP4 and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.

scholarly journals Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein

2001 ◽  
Vol 98 (24) ◽  
pp. 14108-14113 ◽  
Author(s):  
J. D. Neely ◽  
M. Amiry-Moghaddam ◽  
O. P. Ottersen ◽  
S. C. Froehner ◽  
P. Agre ◽  
...  
Keyword(s):  
Water Channel ◽  
Aquaporin 4 ◽  
Channel Protein ◽  
Water Channel Protein

Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes

2007 ◽  
Vol 26 (8) ◽  
pp. 2109-2118 ◽  
Author(s):  
Susan Noell ◽  
Petra Fallier-Becker ◽  
Cordian Beyer ◽  
Stephan Kröger ◽  
Andreas F. Mack ◽  
...  
Keyword(s):  
Volume Regulation ◽  
Water Channel ◽  
Aquaporin 4 ◽  
Channel Protein ◽  
Cultured Astrocytes ◽  
Water Channel Protein

scholarly journals Knockdown a Water Channel Protein, Aquaporin-4, Induced Glioblastoma Cell Apoptosis

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e66751 ◽  
Author(s):  
Ting Ding ◽  
Ying Zhou ◽  
Kai Sun ◽  
Weizhong Jiang ◽  
Wenliang Li ◽  
...  
Keyword(s):  
Cell Apoptosis ◽  
Water Channel ◽  
Aquaporin 4 ◽  
Glioblastoma Cell ◽  
Channel Protein ◽  
Water Channel Protein

Expression of the water channel protein, aquaporin-4, in mouse brains exposed to mobile telephone radiofrequency fields

Pathology ◽  
2009 ◽  
Vol 41 (5) ◽  
pp. 473-475 ◽  
Author(s):  
John W. Finnie ◽  
Peter C. Blumbergs ◽  
Zhao Cai ◽  
Jim Manavis
Keyword(s):  
Water Channel ◽  
Mobile Telephone ◽  
Aquaporin 4 ◽  
Channel Protein ◽  
Water Channel Protein
Sign in / Sign up

Export Citation Format

Share Document