Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute: Micro-computed tomographic and histologic observations

2018 ◽  
Vol 29 (3) ◽  
pp. 339-345 ◽  
Author(s):  
Jung-Seok Lee ◽  
Jae-Kook Cha ◽  
Daniel S. Thoma ◽  
Ui-Won Jung
Keyword(s):  
Bone Substitute ◽  
Autopsy Case ◽  
Synthetic Bone ◽  
Computed Tomographic ◽  
Synthetic Bone Substitute ◽  
Human Autopsy ◽  
Maxillary Sinuses

In Vivo Behavior of a Custom-Made 3D Synthetic Bone Substitute in Sinus Augmentation Procedures in Sheep

2015 ◽  
Vol 41 (3) ◽  
pp. 240-250 ◽  
Author(s):  
Carlo Mangano ◽  
Barbara Barboni ◽  
Luca Valbonetti ◽  
Paolo Berardinelli ◽  
Alessandra Martelli ◽  
...  
Keyword(s):  
Bone Substitute ◽  
Three Dimensional ◽  
Chemical Properties ◽  
X Ray Diffraction ◽  
Sinus Augmentation ◽  
Synthetic Bone ◽  
Synthetic Bone Substitute ◽  
Sinus Cavity ◽  
Custom Made

In this study, the in vivo behavior of a custom-made three-dimensional (3D) synthetic bone substitute was evaluated when used as scaffold for sinus augmentation procedures in an animal model. The scaffold was a calcium phosphate ceramic fabricated by the direct rapid prototyping technique, dispense-plotting. The geometrical and chemical properties of the scaffold were first analyzed through light and electron scanning microscopes, helium picnometer, and semi-quantitative X-ray diffraction measurements. Then, 6 sheep underwent monolateral sinus augmentation with the fabricated scaffolds. The animals were euthanized after healing periods of 45 and 90 days, and block sections including the grafted area were obtained. Bone samples were subjected to micro computerized tomography, morphological and histomorphometric analyses. A complete integration of the scaffold was reported, with abundant deposition of newly formed bone tissue within the biomaterial pores. Moreover, initial foci of bone remodeling were mainly localized at the periphery of the implanted area after 45 days, while continuous bridges of mature lamellar bone were recorded in 90-day specimens. This evidence supports the hypothesis that bone regeneration proceeds from the periphery to the center of the sinus cavity. These results showed how a technique allowing control of porosity, pore design, and external shape of a ceramic bone substitute may be valuable for producing synthetic bone grafts with good clinical performances.

In Vitro and In Vivo Osteoinductive and Osteoconductive Properties of a Synthetic Bone Substitute

2013 ◽  
Vol 28 (6) ◽  
pp. e432-e439 ◽  
Author(s):  
Enrico Conserva ◽  
Federico Foschi ◽  
Ranieri Cancedda ◽  
Maddalena Mastrogiacomo
Keyword(s):  
Bone Substitute ◽  
Synthetic Bone ◽  
Synthetic Bone Substitute
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