Comparative evaluation of the combined application of titanium implants and calcium phosphate bone substitutes in a rabbit model

2014 ◽  
Vol 26 (10) ◽  
pp. 1215-1221 ◽  
Author(s):  
Arwa Alsayed ◽  
Sukumaran Anil ◽  
John A. Jansen ◽  
Jeroen J. J. P. van den Beucken
Keyword(s):  
Calcium Phosphate ◽  
Comparative Evaluation ◽  
Rabbit Model ◽  
Bone Substitutes ◽  
Titanium Implants ◽  
Combined Application

Value Added Bioceramics: A Review of the Developments and Progress in India

2016 ◽  
Vol 696 ◽  
pp. 3-8 ◽  
Author(s):  
T.S. Sampath Kumar
Keyword(s):  
Raw Materials ◽  
Early Stage ◽  
Rabbit Model ◽  
Value Added ◽  
Bone Substitutes ◽  
Titanium Implants ◽  
Raw Material ◽  
Minor Amount ◽  
Bovine Bone ◽  
Carbonate Apatite

The development of the calcium phosphate ceramics (CPC) using natural materials such as coral, eggshell, bovine bone, fish bone etc., from Indian origin have been reviewed. The CPCs from natural sources has the benefit that they inherit some of the properties of the raw materials such as the macro-and micro-pore structure, optimal composition, similar morphology etc., as well as the advantage of unlimited world wide availability at a very low raw material cost. Hydroxyapatite (HA), carbonated HA and fluorapatite from natural coral genus "Goniopora” has been obtained. Growth factor loaded coralline HA has been found to significantly accelerate early-stage bone formation in in vivo rabbit model studies. Sea shells have been tested as the source of calcium for electrochemical deposition of HA on titanium implants. Deproteinized hydroxyl carbonate apatite phase was formed by heating adult bovine tibia at 500o C. As eggshell could be easily procured, a great deal of effort has been made to utilize this resource as value-added CPCs including nanocrystalline HA (OHA), calcium deficient HA (CDHA), TCP, tetracalcium phosphate (TTCP) etc., which are the most widely used bone substitutes. Also OHA showed higher antibiotic delivery and more controlled protein release profile compared to the synthetic apatites. Eggshell derived CPCs were also found to have minor amount of Mg, Sr, Si and Na ions inherited from the eggshell. As these ions are crucial for bio-mineralization of eggshell, the influence of multi-ions substituted CPCs as a potential bioceramic for bone regenerative applications has been emphasised.

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020 ◽  
Vol 61 (6) ◽  
pp. 177-187
Author(s):  
Till Kämmerer ◽  
Tony Lesmeister ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Statistical Difference ◽  
Surface Modifications ◽  
Titanium Implants ◽  
In Vivo Model ◽  
Implant Surface ◽  
Press Fit ◽  
Endosseous Implant ◽  
Bone To Implant Contact

Introduction: We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. Materials and Methods: A total of 36 cylindrical press-fit implants with two different surfaces (CaP, n = 18; SA, n = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). Results: After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. Conclusion: Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.

Elaboration of a triphasic calcium phosphate and silica nanocomposite for maxillary grafting and deposition on titanium implants

2018 ◽  
Vol 109 (1) ◽  
pp. 68-75
Author(s):  
Nelson Heriberto Almeida Camargo ◽  
Enori Gemelli ◽  
Laís Schmitz Passoni ◽  
Priscila Ferraz Franczak ◽  
Pricyla Corrêa
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Silica Nanocomposite

Polymer-calcium phosphate cement composites for bone substitutes

2002 ◽  
Vol 61 (4) ◽  
pp. 581-592 ◽  
Author(s):  
Rafal A. Mickiewicz ◽  
Anne M. Mayes ◽  
David Knaack
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Bone Substitutes ◽  
Cement Composites

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

Effect of Zoledronic Acid on Osseointegration of Titanium Implants: An Experimental Study in an Ovariectomized Rabbit Model

2010 ◽  
Vol 68 (3) ◽  
pp. 515-523 ◽  
Author(s):  
Alper Yıldız ◽  
Emin Esen ◽  
Mehmet Kürkçü ◽  
İbrahim Damlar ◽  
Kenan Dağlıoğlu ◽  
...  
Keyword(s):  
Experimental Study ◽  
Zoledronic Acid ◽  
Rabbit Model ◽  
Titanium Implants
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