Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute - a split-mouth pilot study

2013 ◽  
Vol 25 (10) ◽  
pp. 1175-1181 ◽  
Author(s):  
Angelika Wildburger ◽  
Michael Payer ◽  
Norbert Jakse ◽  
Dirk Strunk ◽  
Nathalie Etchard-Liechtenstein ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
Bone Regeneration ◽  
Bone Substitute ◽  
Bone Marrow Aspirate ◽  
Bovine Bone ◽  
Concentrated Bone Marrow ◽  
Sinus Floor Augmentation ◽  
Sinus Floor

scholarly journals Clinical Safety Assessment of Autologous Freeze-Drying Platelet-Rich Plasma for Bone Regeneration in Maxillary Sinus Floor Augmentation: A Pilot Study

2021 ◽  
Vol 10 (8) ◽  
pp. 1678
Author(s):  
Takamitsu Koga ◽  
Yuya Nakatani ◽  
Seigo Ohba ◽  
Masahito Hara ◽  
Yoshinori Sumita ◽  
...  
Keyword(s):  
Clinical Study ◽  
Pilot Study ◽  
Bone Regeneration ◽  
Maxillary Sinus ◽  
Freeze Drying ◽  
Platelet Rich Plasma ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Maxillary Sinus Floor Augmentation

The purpose of this clinical study is to evaluate the safety and preliminary efficacy of autologous freeze-drying platelet-rich plasma (FD-PRP) on bone regeneration in maxillary sinus floor augmentation as a preliminary pilot study. Five patients that required sinus floor augmentation to facilitate the placement of dental implants participated in this clinical study. The PRP was prepared from the autologous peripheral blood and was lyophilized and stored at −20 °C for 4 weeks before surgery. At surgery, triple-concentrated FD-PRP (x3FD-PRP) mixed with synthetic bone grafting materials was rehydrated following the transplantation into the sinus floor. The primary outcome was a safety verification of x3FD-PRP, evaluated in terms of the clinical course and consecutive blood tests. The secondary outcome was clinical efficacy focused on bone regeneration in sinus floor augmentation evaluated by radiographic examination and implant stability. There were no adverse events, such as systemic complications, excessive inflammatory reactions, severe infection, or local site healing complications, besides those on the usual course associated with surgery. Vertical augmented height was maintained, and the initial stability of implants was achieved post-operatively in 6 months. The results obtained in this study suggest that x3FD-PRP can be used safely for bone engineering in clinical practice. Further studies are required to draw a conclusion concerning the efficacy of x3FD-PRP since this was a pilot study with a single arm and a small sample size.

Double Centrifugation Versus Single Centrifugation of Bone Marrow Aspirate Concentrate in Sinus Floor Elevation: A Pilot Study

2016 ◽  
Vol 31 (1) ◽  
pp. 216-222 ◽  
Author(s):  
Thiago de Oliveira ◽  
Antonio Aloise ◽  
José Orosz ◽  
Rafael de Mello e Oliveira ◽  
Paulo de Carvalho ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
Bone Marrow Aspirate ◽  
Sinus Floor Elevation ◽  
Bone Marrow Aspirate Concentrate ◽  
Sinus Floor

scholarly journals Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Jean-Philippe Hauzeur ◽  
Valérie Gangji
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adult Stem Cells ◽  
Bone Marrow Aspirate ◽  
Direct Injection ◽  
Case Series ◽  
Autologous Bone Marrow ◽  
Bone Necrosis ◽  
Concentrated Bone Marrow ◽  
Made In

Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection—15 to 150 ml—was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.

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