A doxycycline-treated hydroxyapatite implant surface attenuates the progression of peri-implantitis: A radiographic and histological study in mice

2018 ◽  
Vol 21 (1) ◽  
pp. 154-159 ◽  
Author(s):  
Lin Ding ◽  
Peng Zhang ◽  
Xin Wang ◽  
Shohei Kasugai
Author(s):  
Maklygina Yu S ◽  
Sharova AS ◽  
Kundu B ◽  
Balla VK ◽  
Steiner R ◽  
...  

2018 ◽  
Vol 786 ◽  
pp. 236-247
Author(s):  
Dawlat Mostafa Ahmed ◽  
Samia Soliman Omar

Background: Osseointegration of dental implant is a challenging issue for those who need to restore a missing tooth, a matter that necessitates wide range of research on different implant manufacturing, modification and bioactive coating materials.Aim of the study: Investigation of cementing line configuration around osseointegrated engineered nano-porous zirconia implants coated with bioactive autologous HA, platelet rich plasma (PRP) and bovine HA (Bio-oss) coatings in rabbit model.Materials and methods: Zirconia implants (cylinders 3.7 mm x 8 mm) were milled and sintered according to manufacturer recommendations. Then all specimens were treated with selective infiltration etching (SIE) to produce a nano-porous surface. Implants were surgically placed bilaterally in the femur distal heads of 20 male line V Spain white rabbits. Implants were divided equally into 4 groups (n=10): group (A) control (non-coated), group (B) autologous HA coated, group (C) PRP coated and group (D) Bio-Oss coated implants. Specimens were characterized with x-ray diffraction (XRD) analysis and mercury porosimetery. Histological examination was performed after six weeks of peri-implant healing period.Results: XRD patterns revealed the detection of hexagonal HA and (Y-TZP) tetragonal crystal phases for the HA coated surfaces. Mercury porosimetery revealed a significant reduction in total porosity percent after application of bioactive coating materials. The histological picture of osseiointegration and cementing line continuity in association with both of autologous HA and PRP were outstanding and satisfactory followed by that of Bio-Oss and all coated implants showed a noticeable difference from that of the control specimens that were surrounded by unsupported cementing line adjacent to newly formed bone with low density.Conclusions: Engineering of zirconia implant surface with bioactive coatings either HA or PRP to enhance its biological activity could be considered as reliable method to provide satisfactory osseiointegration.


2015 ◽  
Vol 15 (10) ◽  
pp. 7976-7979 ◽  
Author(s):  
Dong Seok Seo ◽  
Jong Kook Lee ◽  
Kyu Hong Hwang

Hydroxyapatite (HA) is widely used as a bioactive ceramics as it forms a chemical bond with bone. However, the drawback to using this material is its inferior mechanical properties. In this research, surface corrosion and disintegration of nanoscaled HA in a dog were studied, and the mechanism by which phase-pure HA dissolved In Vivo was investigated. Biological properties of HA In Vivo are affected by the grain-boundary dissolution followed by a surface corrosion and microstructural disintegration. This kind of dissolution process, apparently evidenced at the grain boundary, causes particle generation, which indicates that both long-term bone in-growth and mechanical properties can dramatically deteriorate. Implant dissolution by osteoclasts In Vivo is also observed on the surface of hydroxyapatite. Implant surface showed an aggressive corrosion by an osteoclast resorption. Severe and deeper dissolution underwent close to osteoclast resulting in formation of smaller and more round particle shape.


2007 ◽  
Vol 80B (2) ◽  
pp. 377-385 ◽  
Author(s):  
Jamil Awad Shibli ◽  
Sauro Grassi ◽  
Luciene Cristina de Figueiredo ◽  
Magda Feres ◽  
Elcio Marcantonio ◽  
...  

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