In Vivo Regenerative Properties of Coralline-Derived (Biocoral) Scaffold Grafts in Human Maxillary Defects: Demonstrative and Comparative Study with Beta-Tricalcium Phosphate and Biphasic Calcium Phosphate by Synchrotron Radiation X-Ray Microtomography

2013 ◽  
Vol 16 (5) ◽  
pp. 736-750 ◽  
Author(s):  
Alessandra Giuliani ◽  
Adrian Manescu ◽  
Emanuel Larsson ◽  
Giuliana Tromba ◽  
Giuseppe Luongo ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Synchrotron Radiation ◽  
Comparative Study ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
X Ray ◽  
Beta Tricalcium Phosphate ◽  
Maxillary Defects

The Preparation and Morphology of Biphasic Calcium Phosphate Ceramics

2012 ◽  
Vol 506 ◽  
pp. 198-201
Author(s):  
P. Saiwanich ◽  
Kamonpan Pengpat ◽  
G. Rujijanagul ◽  
U. Intatha ◽  
Sukum Eitssayeam
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
X Ray Diffraction ◽  
Casting Method ◽  
X Ray ◽  
Gel Casting ◽  
Beta Tricalcium Phosphate ◽  
Ceramic Microstructure ◽  
Ball Milling Technique

In this work, thepreparation and morphology of biphasic calcium phosphate (BCP) have been studied. The biphasic calcium phosphate (BCP) ceramics were prepared by mixing between hydroxyapatite (HA) and Beta-tricalcium phosphate (β-TCP) powderby ball milling technique with different ratios (100:0,80:20,60:40,50:50,40:60, 20:80 and 0:100). After that the mixtures were forming by Gel casting method and then sintered at 1200°C, respectively. The phase formation of the biphasic calcium phosphateceramics were studied by X-ray diffraction (XRD) and their ceramic microstructure,shrinkage and density were investigated.

Bimodal Porous Bi-Phasic Calcium Phosphate Ceramics and Its Dissolution in SBF Solution

2007 ◽  
Vol 330-332 ◽  
pp. 91-94 ◽  
Author(s):  
Y. Zhang ◽  
Yoshiyuki Yokogawa ◽  
Tetsuya Kameyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Reaction Rate ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramics ◽  
Fine Powders ◽  
Beta Tricalcium Phosphate ◽  
Sbf Solution ◽  
New Phase

Biphasic calcium phosphate (BCP) ceramics, a mixture of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP), of varying HAp/β-TCP ratios were prepared from fine powders. Porous BCP ceramic materials with HAp/β-TCP weight rations of 20/80, 40/60, and 80/20 were prepared. In this study, the bioactivity is reduced at a larger HAp content rate, which is likely related to the high driving pore for the formation of a new phase, and the reaction rate was proportional to the β-TCP. The porous BCP ceramics having a bigger porosity rate can easily under up dissolution. The powder having a larger β-TCP content rate can easily generate a new phase. The dissolution results confirmed that the biodegradation of calcium phosphate ceramics could be controlled by simply adjusting the amount of HAp or β-TCP in the ceramics and porosity rate.

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization In Vivo Six Months after Implantation

2016 ◽  
Vol 721 ◽  
pp. 229-233 ◽  
Author(s):  
Sandris Petronis ◽  
Janis Locs ◽  
Vita Zalite ◽  
Mara Pilmane ◽  
Andrejs Skagers ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Mineralization ◽  
Bone Substitutes ◽  
Tissue Response ◽  
Control Group ◽  
Osteoporotic Bone ◽  
Local Recovery

Calcium bone substitutes are successfully used for local recovery of osteoporotic bone and filling of bone defects. Previous studies revieled that biphasic calcium phosphate (BCP) show better bioactivity in compare to pure β-tricalcium phosphate or hydroxyapatite. Also increased porosity of material promotes better bone tissue response. Aim of this experiment was to evaluate immunohistologically response of osteoporotic bone of experimental animal to implantation of granules with hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) ratio of 90/10. Calcium phosphate (CaP) was synthesized by aqueous precipitation technique from calcium hydroxide and phosphoric acid. Bioceramic granules in size range from 1.0 to 1.4 mm were prepared with nanopore sizes around 200 nm. We used nine female rabbits with induced osteoporosis in this experiment. Six animals in study group underwent implantation of BCP in hip bone defect and three animals in control group left without BCP implantation. After 6 months animals were euthanized, bone samples collected and proceeded for detection of bone activity and repair markers: osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG). Controls showed the presence of experimental bone osteoporosis. In experimental group bone showed partially resorbed bioceramic granules and in some samples new bone formation near the granuli was observed. Increase of OC and OPG up to twice as to compare to control group were detected as well. Implantation of BCP granules in osteoporotic rabbit bone increases expression of OC and OPG indicating the activation of osteoblastogenesis and bone mineralization in vivo.

Quantitative Kinetics Evaluation of Blocks Versus Granules of Biphasic Calcium Phosphate Scaffolds (HA/β-TCP 30/70) by Synchrotron Radiation X-ray Microtomography

2016 ◽  
Vol 25 (1) ◽  
pp. 6-15 ◽  
Author(s):  
Alessandra Giuliani ◽  
Adrian Manescu ◽  
Sara Mohammadi ◽  
Serena Mazzoni ◽  
Adriano Piattelli ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Synchrotron Radiation ◽  
Biphasic Calcium Phosphate ◽  
X Ray

scholarly journals Evaluation of Bone Repair in the Mandible of Rabbits Using Biphasic Calcium Phosphate Micro-Macroporous Hydroxyapatite Bioceramics and Beta-Tricalcium Phosphate

2019 ◽  
Vol 19 (1) ◽  
pp. 1-12
Author(s):  
Francisco Franceschini Neto ◽  
Rudyard dos Santos Oliveira ◽  
Ana Paula Altheman Lopes ◽  
Carlos Eduardo Xavier dos Santos Ribeiro da Silva
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Repair ◽  
Beta Tricalcium Phosphate

scholarly journals Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 617
Author(s):  
Ji-Bong Choi ◽  
Yu-Kyoung Kim ◽  
Seon-Mi Byeon ◽  
Jung-Eun Park ◽  
Tae-Sung Bae ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Cell Viability ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Composite Hydrogel ◽  
Beta Tricalcium Phosphate ◽  
High Bone

In the field of bone tissue, maintaining adequate mechanical strength and tissue volume is an important part. Recently, biphasic calcium phosphate (BCP) was fabricated to solve the shortcomings of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP), and it is widely studied in the field of bone-tissue engineering. In this study, a composite hydrogel was fabricated by applying BCP to gelatin methacrylate (GelMA). It was tested by using a mechanical tester, to characterize the mechanical properties of the prepared composite hydrogel. The fabricated BCP was analyzed through FTIR and XRD. As a result, a different characteristic pattern from hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) was observed, and it was confirmed that it was successfully bound to the hydrogel. Then, the proliferation and differentiation of preosteoblasts were checked to evaluate cell viability. The analysis results showed high cell viability and relatively high bone differentiation ability in the composite hydrogel to which BCP was applied. These features have been shown to be beneficial for bone regeneration by maintaining the volume and shape of the hydrogel. In addition, hydrogels can be advantageous for clinical use, as they can shape the structure of the material for custom applications.

scholarly journals Comparative Study between Laser Light Stereo-Lithography 3D-Printed and Traditionally Sintered Biphasic Calcium Phosphate Scaffolds by an Integrated Morphological, Morphometric and Mechanical Analysis

2019 ◽  
Vol 20 (13) ◽  
pp. 3118 ◽  
Author(s):  
Carlo Mangano ◽  
Francesco Mangano ◽  
Luigi Gobbi ◽  
Oleg Admakin ◽  
Satoshi Iketani ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Comparative Study ◽  
Biphasic Calcium Phosphate ◽  
Laser Light ◽  
Plastic Region ◽  
Compressive Loading ◽  
Mechanical Analysis ◽  
3D Printed ◽  
Loading Tests

In dental districts, successful bone regeneration using biphasic calcium phosphate materials was recently explored. The present study aimed to perform a comparative study between 3D-printed scaffolds produced by laser light stereo-lithography (SLA) and traditionally sintered biphasic calcium phosphate scaffolds by an integrated morphological, morphometric and mechanical analysis. Methods: Biphasic calcium phosphate (30% HA/70% β-TCP) samples, produced by SLA-3D-printing or by traditional sintering methods, were tested. The experimental sequence included: (1) Microtomography (microCT) analyses, to serve as control-references for the 3D morphometric analysis; (2) loading tests in continuous mode, with compression up to fracture, to reconstruct their mechanical characteristics; and (3) microCT of the same samples after the loading tests, for the prediction of the morphometric changes induced by compressive loading of the selected materials. All the biomaterials were also studied by complementary scanning electron microscopy to evaluate fracture regions and surfaces. Results: The characterization of the 3D mineralized microarchitecture showed that the SLA-3D-printed biomaterials offer performances comparable to and in some cases better than the traditionally sintered ones, with higher mean thickness of struts and pores. Interestingly, the SLA-3D-printed samples had a higher ultimate strength than the sintered ones, with a smaller plastic region. Moreover, by SEM observation, it was observed that fractures in the SLA-3D-printed samples were localized in the structure nodes or on the external shells of the rods, while all the traditionally sintered samples revealed a ductile fracture surface. Conclusions: The reduction of the region of plastic deformation in the SLA-3D-printed samples with respect to traditionally sintered biomaterials is expected to positively influence, in vivo, the cell adhesion. Both microCT and SEM imaging revealed that the studied biomaterials exhibit a structure more similar to human jaw than the sintered biomaterials.

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