scholarly journals Interactive Sculpting of Digital Faces Using an Anatomical Modeling Paradigm

2020 ◽  
Vol 39 (5) ◽  
pp. 93-102
Author(s):  
A. Gruber ◽  
M. Fratarcangeli ◽  
G. Zoss ◽  
R. Cattaneo ◽  
T. Beeler ◽  
...  
Keyword(s):  
Modeling Paradigm ◽  
Anatomical Modeling

A Control-Theoretic Approach to Neural Pharmacology: Optimizing Drug Selection and Dosing

2016 ◽  
Vol 138 (8) ◽  
Author(s):  
Gautam Kumar ◽  
Seul Ah Kim ◽  
ShiNung Ching
Keyword(s):  
Design Method ◽  
Target Space ◽  
Theoretic Approach ◽  
Time Varying ◽  
Drug Selection ◽  
Modeling Paradigm ◽  
Dosing Strategies ◽  
Dose Dependent ◽  
Optimal Construction ◽  
Selection Of

The induction of particular brain dynamics via neural pharmacology involves the selection of particular agonists from among a class of candidate drugs and the dosing of the selected drugs according to a temporal schedule. Such a problem is made nontrivial due to the array of synergistic drugs available to practitioners whose use, in some cases, may risk the creation of dose-dependent effects that significantly deviate from the desired outcome. Here, we develop an expanded pharmacodynamic (PD) modeling paradigm and show how it can facilitate optimal construction of pharmacologic regimens, i.e., drug selection and dose schedules. The key feature of the design method is the explicit dynamical-system based modeling of how a drug binds to its molecular targets. In this framework, a particular combination of drugs creates a time-varying trajectory in a multidimensional molecular/receptor target space, subsets of which correspond to different behavioral phenotypes. By embedding this model in optimal control theory, we show how qualitatively different dosing strategies can be synthesized depending on the particular objective function considered.

Towards a Model-Centric Approach for Developing Enterprise Information Systems

2010 ◽  
pp. 140-158
Author(s):  
Petraq Papajorgji ◽  
Panos M. Pardalos
Keyword(s):  
Information Systems ◽  
Software Development ◽  
Programming Languages ◽  
Development Process ◽  
Software Development Process ◽  
Object Constraint Language ◽  
Enterprise Information ◽  
Enterprise Information Systems ◽  
Model Driven ◽  
Modeling Paradigm

This chapter aims to present a new modeling paradigm that promises to significantly increase the efficiency of developing enterprise information systems. Currently, the software industry faces considerable challenges as it tries to build larger, more complex, software systems with fewer resources. Although modern programming languages such as C++ and Java have in general improved the software development process, they have failed to significantly increase developer’s productivity. Thus, developers are considering other paths to address this issue. One of the potential paths is designing, developing and deploying enterprise information systems using the Model Driven Architecture (MDA). MDA is a model-centric approach that allows for modeling the overall business of an enterprise and capturing requirements to developing, deploying, integrating, and managing different kinds of software components without considering any particular implementation technology. At the center of this approach are models; the software development process is driven by constructing models representing the software under development. Code that expresses the implementation of the model in a certain underlying technology is obtained as a result of model transformation. Thus, the intellectual investment spent in developing the business model of an enterprise is not jeopardized by the continuous changes of the implementation technologies. Currently there are two main approaches trying to implement MDA-based tools. One of the approaches is based on the Object Constraint Language and the other on Action Language. An example of designing, developing and deploying an application using this new modeling paradigm is presented. The MDA approach to software development is considered as the biggest shift since the move from Assembler to the first high level languages.

Geometric Surface Features Applied to Volumetric CAE Mesh Models

2005 ◽  
Author(s):  
Yifan Chen ◽  
Basavaraj Tonshal ◽  
Ali Saeed
Keyword(s):  
Large Scale ◽  
Geometric Feature ◽  
Direct Modeling ◽  
Modeling Paradigm ◽  
Model Independent ◽  
User Friendly ◽  
Geometric Surface ◽  
Mesh Models ◽  
Modeling Clay ◽  
Blending Function

In this paper, we discuss a way to extend a geometric surface feature framework known as Direct Surface Manipulation (DSM) into a volumetric mesh modeling paradigm that can be directly adopted by large-scale CAE applications involving models made of volumetric elements, multiple layers of surface elements or both. By introducing a polynomial-based depth-blending function, we extend the classic DSM mathematics into a volumetric form. The depth-blending function possesses similar user-friendly features as DSM basis functions permitting ease-of-control of the continuity and magnitude of deformation along the depth of deformation. Practical issues concerning the implementation of this technique are discussed in details and implementation results are shown demonstrating the versatility of this volumetric paradigm for direct modeling of complex CAE mesh models. In addition, the notion of a model-independent, volumetric-geometric feature is introduced. Motivated by modeling clay with sweeps and templates, a model-independent, catalog-able volumetric feature can be created. Deformation created by such a feature can be relocated, reoriented, duplicated, mirrored, pasted, and stored independent of the model to which it was originally applied. It can serve as a design template, thereby saving the time and effort to recreate it for repeated uses on different models (frequently seen in CAE-based Design of Experiments study).

A generalizable deep-learning approach to anatomical modeling of brain vasculature (Conference Presentation)

2020 ◽  
Author(s):  
Waleed Tahir ◽  
Jiabei Zhu ◽  
Sreekanth Kura ◽  
Xiaojun Cheng ◽  
Rafat Damseh ◽  
...  
Keyword(s):  
Deep Learning ◽  
Learning Approach ◽  
Brain Vasculature ◽  
Anatomical Modeling

scholarly journals Object-centric programming: A new modeling paradigm for robotic applications

2009 ◽  
Author(s):  
Andreas Angerer ◽  
Alwin Hoffmann ◽  
Frank Ortmeier ◽  
Michael Vistein ◽  
Wolfgang Reif
Keyword(s):  
Modeling Paradigm ◽  
Robotic Applications
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