scholarly journals Clinical and social characteristics associated with reduced visual acuity at presentation in Australian patients with neovascular age-related macular degeneration: a prospective study from a long-term observational data set. The Fight Retinal Blindness! P

2017 ◽  
Vol 46 (3) ◽  
pp. 266-274 ◽  
Author(s):  
Vuong Nguyen ◽  
Vincent Daien ◽  
Robyn H Guymer ◽  
Ian L McAllister ◽  
Nigel Morlet ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Prospective Study ◽  
Macular Degeneration ◽  
Observational Data ◽  
Age Related Macular Degeneration ◽  
Social Characteristics ◽  
Data Set ◽  
Age Related ◽  
A Prospective Study

A Comparison of Radial and Horizontal Macular Optical Coherence Tomography on Detection of Macular Pathology: A Prospective Study at an Academic Institution

2021 ◽  
pp. 247412642199705
Author(s):  
Halward M.J. Blegen ◽  
Samuel D. Hobbs ◽  
Reggie Taylor ◽  
Andrew L. Plaster ◽  
Paul M. Drayna
Keyword(s):  
Optical Coherence Tomography ◽  
Prospective Study ◽  
Macular Degeneration ◽  
Epiretinal Membrane ◽  
Central Serous Chorioretinopathy ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Macular Diseases ◽  
A Prospective Study

Purpose: Optical coherence tomography (OCT) is useful in diagnosing and monitoring retinal pathology such as age-related macular degeneration, diabetic macular edema (DME), central serous chorioretinopathy, and epiretinal membrane, among others. This study compared the ability of horizontal (H) 25-, 13-, and 7-cut macular OCT vs 24-, 12-, and 6-cut radial (R) macular OCT in identifying various macular pathology. Methods: This was a prospective study of 161 established patients evaluated at Wilford Hall Eye Center Retina Clinic between September and October of 2019. Pathology included age-related macular degeneration, central serous chorioretinopathy, DME, and epiretinal membrane, among others. Patients obtained 25-, 13-, and 7-cut H raster OCT as well as 24-, 12-, and 6-cut R OCT. Primary outcomes were sensitivity in detecting macular fluid and each macular abnormality. Results: The 24-cut radial (R24) OCT equally or out-performed the H25 (horizontal 25-cut OCT) in detecting macular fluid across all pathological groups. Generally, a higher number of cuts correlated with better detection of fluid. In detecting any macular abnormalities, H25, R24, and R12 had 100% sensitivity. R6 OCT had near 100% sensitivity across all groups, except for DME (95%). Overall, R OCT had better sensitivity (0.960) than H OCT (0.907) in detecting macular pathology. Conclusions: R outperformed H macular OCT in detecting fluid and other abnormalities. Clinically, both scanning patterns can be used by ophthalmologists in diagnosis and management of commonly encountered macular diseases. Technicians may be able to use a variety of these scans to screen for pathology prior to physician evaluation.

A Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration

1999 ◽  
Vol 9 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Umed A Ajani ◽  
William G Christen ◽  
Joann E Manson ◽  
Robert J Glynn ◽  
Debra Schaumberg ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Prospective Study ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
A Prospective Study

scholarly journals Projection of Long-Term Visual Acuity Outcomes Based on Initial Treatment Response in Neovascular Age-Related Macular Degeneration

Ophthalmology ◽  
2019 ◽  
Vol 126 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Vuong Nguyen ◽  
Vincent Daien ◽  
Robyn Guymer ◽  
Stephanie Young ◽  
Alex Hunyor ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Treatment Response ◽  
Initial Treatment ◽  
Age Related Macular Degeneration ◽  
Age Related

Predicting visual outcomes in patients treated with aflibercept for neovascular age-related macular degeneration: Data from a real-world clinical setting

2019 ◽  
Vol 30 (3) ◽  
pp. 543-549 ◽  
Author(s):  
Corinne Fulcher ◽  
Charlotte A Hazel ◽  
Ian Pacey ◽  
Hasan Ali ◽  
Faruque D Ghanchi
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Predictive Factor ◽  
Retinal Thickness ◽  
Age Related Macular Degeneration ◽  
Central Retinal Thickness ◽  
Response To Treatment ◽  
Long Term Outcome ◽  
Age Related

Background/objectives: There is a significant variation in the way neovascular age-related macular degeneration patients respond to anti–vascular endothelial growth factor treatment. Both the financial and time cost of treatment are significant. As such, being able to predict patient response to treatment is valuable. Subjects/methods: 72 eyes treated with intravitreal aflibercept were retrospectively included in analysis. For each subject, visual acuity (letters) and central retinal thickness (µm) at baseline, second, third and fourth visits, as well as 12-month visits, were collated; a plot of visual acuity versus time was generated and a slope of the first three (slope3) and first four (slope4) visits was calculated. Differences in visual acuity at each visit compared to baseline were determined, as well as percentage differences in central retinal thickness at each visit compared to baseline. Lesion sub-type and the presence of fluid and haemorrhage were also recorded. Results: The average change in visual acuity over 12 months was +3.2 ± 13.4 letters with 91.2% of patients losing <15 letters. Slope4 was the only significant predictive factor for ‘visual acuity change over 12 months’ ( p < 0.001). Change in central retinal thickness, lesion sub-type, haemorrhage at baseline and the location of fluid at baseline were not useful predictive factors in long-term outcome. Conclusion: Aflibercept is an effective treatment option for neovascular age-related macular degeneration; however, the long-term response should not be predicted until at least three loading dose injections have been given. Visual acuity measures at each visit should be examined, as it is the trend in visual acuity across the first four visits (slope4) rather than the difference in visual acuity between two visits that is the predictive factor.

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