Effect of vitamin D on blood-brain barrier function in multiple sclerosis

2017 ◽  
Vol 8 (3) ◽  
pp. 180-180 ◽  
Author(s):  
Akio Suzumura
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown

2019 ◽  
Vol 20 (3) ◽  
pp. 602 ◽  
Author(s):  
Axel Haarmann ◽  
Michael Schuhmann ◽  
Christine Silwedel ◽  
Camelia-Maria Monoranu ◽  
Guido Stoll ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Tight Junction ◽  
Human Brain ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Morphological Changes ◽  
Brain Barrier ◽  
Microvascular Endothelial Cell ◽  
Inflammatory Conditions ◽  
Blood Brain

Chemokines (C-X-C) motif ligand (CXCL) 5 and 8 are overexpressed in patients with multiple sclerosis, where CXCL5 serum levels were shown to correlate with blood–brain barrier dysfunction as evidenced by gadolinium-enhanced magnetic resonance imaging. Here, we studied the potential role of CXCL5/CXCL8 receptor 2 (CXCR2) as a regulator of paraendothelial brain barrier function, using the well-characterized human cerebral microvascular endothelial cell line hCMEC/D3. Low basal CXCR2 mRNA and protein expression levels in hCMEC/D3 were found to strongly increase under inflammatory conditions. Correspondingly, immunohistochemistry of brain biopsies from two patients with active multiple sclerosis revealed upregulation of endothelial CXCR2 compared to healthy control tissue. Recombinant CXCL5 or CXCL8 rapidly and transiently activated Akt/protein kinase B in hCMEC/D3. This was followed by a redistribution of tight junction-associated protein zonula occludens-1 (ZO-1) and by the formation of actin stress fibers. Functionally, these morphological changes corresponded to a decrease of paracellular barrier function, as measured by a real-time electrical impedance-sensing system. Importantly, preincubation with the selective CXCR2 antagonist SB332235 partially prevented chemokine-induced disturbance of both tight junction morphology and function. We conclude that human brain endothelial CXCR2 may contribute to blood–brain barrier disturbance under inflammatory conditions with increased CXCL5 and CXCL8 expression, where CXCR2 may also represent a novel pharmacological target for blood–brain barrier stabilization.

Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function during neuroinflammation in multiple sclerosis

2014 ◽  
Vol 275 (1-2) ◽  
pp. 31-32
Author(s):  
Mark Mizee ◽  
Philip Nijland ◽  
Susanne Van Der Pol ◽  
Joost Drexhage ◽  
Bert Van Het Hof ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Retinoic Acid ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Active form of vitamin D directly protects the blood-brain barrier in multiple sclerosis

2017 ◽  
Vol 8 (3) ◽  
pp. 244-254 ◽  
Author(s):  
Shiori Takahashi ◽  
Toshihiko Maeda ◽  
Yasuteru Sano ◽  
Hideaki Nishihara ◽  
Yukio Takeshita ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Blood Brain Barrier ◽  
Active Form ◽  
Brain Barrier ◽  
Blood Brain

Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function in multiple sclerosis

2014 ◽  
Vol 128 (5) ◽  
pp. 691-703 ◽  
Author(s):  
Mark R. Mizee ◽  
Philip G. Nijland ◽  
Susanne M. A. van der Pol ◽  
Joost A. R. Drexhage ◽  
Bert van het Hof ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Retinoic Acid ◽  
Blood Brain Barrier ◽  
Barrier Function ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Sleep Restriction Impairs Blood-Brain Barrier Function

2014 ◽  
Vol 34 (44) ◽  
pp. 14697-14706 ◽  
Author(s):  
J. He ◽  
H. Hsuchou ◽  
Y. He ◽  
A. J. Kastin ◽  
Y. Wang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Barrier Function ◽  
Brain Barrier ◽  
Sleep Restriction ◽  
Blood Brain
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