Circulating insulin‐like growth factor 1 levels are reduced in very young children with Prader–Willi syndrome independent of anthropometric parameters and nutritional status

2021 ◽  
Author(s):  
Mikiko Koizumi ◽  
Ayako Konishi ◽  
Yuri Etani ◽  
Shinobu Ida ◽  
Masanobu Kawai
Keyword(s):  
Growth Factor ◽  
Young Children ◽  
Nutritional Status ◽  
Prader Willi Syndrome ◽  
Insulin Like Growth Factor ◽  
Anthropometric Parameters ◽  
Very Young Children

scholarly journals Role of Nutritional Status in the Regulation of Adrenarche1

1999 ◽  
Vol 84 (11) ◽  
pp. 3936-3944
Author(s):  
Thomas Remer ◽  
Friedrich Manz
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Healthy Children ◽  
Insulin Like Growth Factor ◽  
Adrenal Androgen ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I ◽  
Excretion Rates

The factors regulating adrenarche are unknown. Recent in vitro studies have demonstrated that insulin and insulin-like growth factor I induce major adrenal steroidogenic enzyme genes and increase the production of adrenal androgens. Literature findings strongly suggest that changes in body mass index (BMI) reflect an integrated nonhormonal index of changes in serum levels and/or bioactivities of insulin and insulin-like growth factor I. We therefore longitudinally investigated individual changes in BMI and urinary 24-h excretion rates of dehydroepiandrosterone sulfate (DHEAS) in a prepuberty (PreC; n = 22, 11 boys and 11 girls) and a puberty (PubC; n = 20, 10 boys and 10 girls) cohort of healthy children. Twenty-four-hour urine samples were collected at yearly intervals during observation periods that lasted at least 4 yr (comprising ≥5 consecutive 24-h urine collections). For 4-yr intervals highly significant tracking coefficients (P < 0.001) of 0.73 (PreC) and 0.93 (PubC) were observed for DHEAS, emphasizing the importance of individual (and genetic) influences on adrenal androgen excretion. In both cohorts almost 3-fold higher median increases in urinary DHEAS excretion rates (P < 0.05) were observed during the 1-yr period of the individually highest rises in BMI compared with the 1-yr period of significantly lower rises in BMI (P < 0.01) in the same children after the factor age was controlled for. However, no consistently significant associations were found between urinary DHEAS output and BMI from simple cross-sectional correlations at defined age points. These findings provide the first in vivo evidence that a change in the nutritional status, measurable in the form of Δ-BMI (but not BMI alone), is an important physiological regulator of adrenarche regardless of individual adrenal androgen excretion level, age, and developmental stage.

scholarly journals 40 YEARS OF IGF1: The emerging connections between IGF1, the intestinal microbiome, Lactobacillus strains and bone growth

2018 ◽  
Vol 61 (1) ◽  
pp. T103-T113 ◽  
Author(s):  
Pierre Poinsot ◽  
Martin Schwarzer ◽  
Noël Peretti ◽  
François Leulier
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Gut Microbiota ◽  
Bone Growth ◽  
Postnatal Growth ◽  
Experimental Models ◽  
Intestinal Microbiome ◽  
Growth Factor Signaling ◽  
Insulin Like Growth Factor ◽  
The Impact

In most animal species, postnatal growth is controlled by conserved insulin/insulin-like growth factor (IGF) signaling. In mammals, juvenile growth is characterized by a longitudinal bone growth resulting from the ossification of the growth plate. This ossification is under IGF1 influence through endocrine and paracrine mechanisms. Moreover, the nutritional status has been largely described as an important factor influencing the insulin/insulin-like growth factor signaling. It is now well established that the gut microbiota modulates the nutrient availability of its host. Hence, studies of the interaction between nutritional status, gut microbiota and bone growth have recently emerged. Here, we review recent findings using experimental models about the impact of gut bacteria on the somatotropic axis and its consequence on the bone growth. We also discuss the perspectives of these studies in opening an entire field for clinical interventions.

Relationship of leptin and insulin-like growth factor I to nutritional status in hemodialyzed children

2003 ◽  
Vol 18 (12) ◽  
pp. 1255-1259 ◽  
Author(s):  
Nesrin Besbas ◽  
Fatih Ozaltin ◽  
Turgay Coşkun ◽  
Sıla Özalp ◽  
Umit Saatçi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Relationship Of
Sign in / Sign up

Export Citation Format

Share Document