Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome

2020 ◽  
Vol 92 (4) ◽  
pp. 350-357 ◽  
Author(s):  
Xuelin Li ◽  
Tianyue Zhang ◽  
Shengxian Li ◽  
Yuying Deng ◽  
Lihua Wang ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zora Lazúrová ◽  
Jana Figurová ◽  
Beáta Hubková ◽  
Jana Mašlanková ◽  
Ivica Lazúrová
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Bisphenol A ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Suppressive Effect ◽  
Human Reproduction ◽  
Control Group ◽  
Ovary Syndrome ◽  
Ovarian Steroidogenesis ◽  
The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

scholarly journals Irregular cycles and steroid hormones in polycystic ovary syndrome

2005 ◽  
Vol 20 (9) ◽  
pp. 2402-2408 ◽  
Author(s):  
Suhail A.R. Doi ◽  
Mona Al-Zaid ◽  
Philip A. Towers ◽  
Christopher J. Scott ◽  
Kamal A.S. Al-Shoumer
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Disorders of the glucose metabolism correlate with the phenotype and the severity in women with polycystic ovary syndrome

2020 ◽  
Vol 93 (1) ◽  
pp. 44-51
Author(s):  
Josef Helden ◽  
Osman Evliyaoglu ◽  
Andreas Küberl ◽  
Ralf Weiskirchen
Keyword(s):  
Glucose Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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