scholarly journals Irregular cycles and steroid hormones in polycystic ovary syndrome

2005 ◽  
Vol 20 (9) ◽  
pp. 2402-2408 ◽  
Author(s):  
Suhail A.R. Doi ◽  
Mona Al-Zaid ◽  
Philip A. Towers ◽  
Christopher J. Scott ◽  
Kamal A.S. Al-Shoumer
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zora Lazúrová ◽  
Jana Figurová ◽  
Beáta Hubková ◽  
Jana Mašlanková ◽  
Ivica Lazúrová
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Bisphenol A ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Suppressive Effect ◽  
Human Reproduction ◽  
Control Group ◽  
Ovary Syndrome ◽  
Ovarian Steroidogenesis ◽  
The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

Relationship between steroid hormones and metabolic profile in women with polycystic ovary syndrome

2017 ◽  
Author(s):  
Zora Lazurova ◽  
Jana Figurova ◽  
Simona Ujhazi ◽  
Jana Mašlankova ◽  
Silvia Toporcerova ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Effect of 7‐Day Whey Protein Supplementation on Steroid Hormones and SHBG in Women with Polycystic Ovary Syndrome (PCOS)

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Emily L. Zumbro ◽  
Manisha Rao ◽  
Shenavia Balcom-Luker ◽  
K. Shane Broughton ◽  
Monique J. LeMieux
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Whey Protein ◽  
Polycystic Ovary ◽  
Protein Supplementation ◽  
Ovary Syndrome

scholarly journals Dysglycemia, Not Altered Sex Steroid Hormones, Affects Cognitive Function in Polycystic Ovary Syndrome

2019 ◽  
Vol 3 (10) ◽  
pp. 1858-1868 ◽  
Author(s):  
Brittany Y Jarrett ◽  
Natalie Vantman ◽  
Reid J Mergler ◽  
Eric D Brooks ◽  
Roger A Pierson ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Function ◽  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Sex Steroid ◽  
Metabolic Abnormalities ◽  
Visuospatial Ability ◽  
Ovary Syndrome ◽  
Control Subjects

Abstract Context Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by multiple reproductive and metabolic abnormalities. Because individual reproductive and metabolic abnormalities modulate working memory in the general population, there is growing interest in whether cognitive function is dually and negatively affected in PCOS. Objective To examine the association of reproductive and metabolic features with cognitive function in women with and without PCOS. Design An observational, cross-sectional study was conducted at an academic clinical research center in North America between 2006 and 2009. Common tests of working memory (i.e., manual dexterity, perceptual speed, and visuospatial ability) were performed by women with PCOS (n = 40) and control subjects (n = 40). Markers of sex steroid hormones, ovulatory function, and cardiometabolic health were also assessed. Results Reduced visuospatial ability was observed in women with PCOS compared with control subjects (P < 0.01). Reduced visuospatial ability was linked to higher levels of hemoglobin A1c in the entire study cohort, independent of body mass index or PCOS status. No associations were observed between visuospatial ability and reproductive features, after controlling for confounding variables. Conclusion Our findings support a role for glycemic control, and not PCOS per se, in cognitive dysfunction in women of reproductive age. Additional studies are needed to understand the short- and long-term effects of dysglycemia on brain health in women with PCOS, given their increased propensity for metabolic comorbidities, compared with control subjects.

Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome

2020 ◽  
Vol 92 (4) ◽  
pp. 350-357 ◽  
Author(s):  
Xuelin Li ◽  
Tianyue Zhang ◽  
Shengxian Li ◽  
Yuying Deng ◽  
Lihua Wang ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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