Hashimoto's thyroiditis: relative recurrence risk ratio and implications for screening of first-degree relatives

2017 ◽  
Vol 87 (2) ◽  
pp. 201-206 ◽  
Author(s):  
Nikita Bothra ◽  
Nalini Shah ◽  
Manjunath Goroshi ◽  
Swati Jadhav ◽  
Sheetal Padalkar ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Hashimoto’S Thyroiditis ◽  
Recurrence Risk ◽  
Hashimoto's Thyroiditis ◽  
First Degree Relatives ◽  
Recurrence Risk Ratio

Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study

2008 ◽  
Vol 68 (4) ◽  
pp. 502-507 ◽  
Author(s):  
E Dernis ◽  
R Said-Nahal ◽  
M-A D’Agostino ◽  
P Aegerter ◽  
M Dougados ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Human Leukocyte ◽  
Recurrence Risk ◽  
Cross Sectional Study ◽  
Linkage Study ◽  
Hla B27 ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Genetic Components ◽  
Recurrence Risk Ratio

Objective:To examine the recurrence of manifestations belonging to the spectrum of spondylarthropathy (SpA) in first-degree relatives of patients with SpA, and to estimate the recurrence risk ratio.Methods:Parents and siblings of consecutive SpA probands have been thoroughly investigated, including clinical data collection, pelvic x ray and human leukocyte antigen (HLA)-B27 status determination. The diagnosis of SpA was made according to European Spondylarthropathy Study Group and/or the Amor criteria. The recurrence risk ratio λ1, which gives an estimate of the weight of genetic factors, was calculated as the ratio of the recurrence risk of SpA in first-degree relatives compared with the population prevalence of SpA. The λnon-HLA was obtained by similar calculations restricted to HLA-B27+ individuals.Results:Most manifestations of SpA were more frequent among the 157 HLA-B27+ relatives of 83 probands than among their 111 HLA-B27- relatives. A diagnosis of SpA was made in 50 relatives of 31 (37%) probands. Recurrence was very similar between parents and siblings, without gender difference, resulting in overall recurrence risk of 12% in first-degree relatives and of 22.7% in HLA-B27+ relatives. The λ1 value was 40 and the λnon-HLA value was 6.5, very close to the λHLA value of 6.25 estimated from linkage study in SpA.Conclusions:A similar recurrence risk of SpA was observed between parents and siblings, consistent with a model of inheritance with no dominance variance and without sex influence. The weight of the non-HLA genetic component was equivalent to that estimated for the HLA locus, and fitted a model of multiplicative interaction between HLA and non-HLA genetic components.

Recurrence Risk Ratio

2013 ◽  
pp. 1633-1633
Author(s):  
Kristine M. Molina ◽  
Kristine M. Molina ◽  
Heather Honoré Goltz ◽  
Marc A. Kowalkouski ◽  
Stacey L. Hart ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Recurrence Risk ◽  
Recurrence Risk Ratio

Comparison of circulating tumor cells (CTC) and disseminated tumor cells (DTC) in patients with colorectal carcinoma for a predictive marker for tumor recurrence.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14548-e14548
Author(s):  
Hideyasu Sakihama ◽  
Nozomi Kobayashi ◽  
Nozomi Minagawa ◽  
Tatsushi Shimokuni ◽  
Shigenori Homma ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Cells ◽  
Risk Ratio ◽  
Tumor Recurrence ◽  
Significant Risk ◽  
Predictive Marker ◽  
Recurrence Risk ◽  
Postoperative Recurrence ◽  
Recurrence Rates ◽  
Recurrence Risk Ratio

e14548 Background: Although the presence of CTC or DTC is proposed as a pridictive or a prognostic marker in the management of colorectal carcinoma patients, it is still well unknown what is different of both types of cells. The aim of this study is to compare CTC and DTC as a predictive marker for tumor recurrence by magnetic activated cell sorting system. Methods: Peripheral blood (PB) samples (n=139) and bone marrow (BM) samples (n=41) were preoperatively collected from colorectal carcinoma patients between February 2009 and March 2012. PB samples were obtainable from all patients who provided their BM samples (n=41). Enrichment of CTC was performed by direct immunomagnetic labeling of EpCAM + cells in PB. Enrichment of DTC was done by negative selection of CD45+cells. Subsequently, double immunofluorescences staining for cytokeratin and CD45 was performed to detect CTC or DTC. PB samples from 20 healthy volunteers and BM samples from 3 patients with benign disease were used as controls. Median follow-up time is 28.5 months (range 10-44). Written informed consent was obtained from all enrolled patients. Results: Preoperative positive rates of CTC and DTC were 20.9% (29/139) and 29.3% (12/41), respectively. No CTC or DTC was found in the control groups. In DTC+patients, only 4 patients were positive for CTC (33.3%), whereas 31% of DTC- patients had CTC. We found 13 patients who experienced postoperative recurrence among 139 patients, 7 patients of whom were CTC positive (53.8%). There is a significant higher incidence of recurrence in CTC+patients (risk ratio=4.4, p<0.01). As for DTC, we found 5 patients with recurrence in 41 patients, 4 patients of whom were DTC positive (80%). DTC+ patients have a significant risk of recurrence (risk ratio=9.7, p=0.01). The relationship of CTC / DTC status and the recurrence rates is as follows: 50 % in CTC+/DTC+ patients (2/4); 11.1% in CTC+/DTC- patients (1/9); 25% in CTC-/DTC+ patients (2/8); 0% in CTC-/DTC-patients (0/20). Conclusions: DTC status is more predictive for postoperative recurrence than CTC status. The combination of CTC and DTC analysis might predict recurrence risk more accurately than either of the two analyses.

scholarly journals Familial Intracranial Aneurysms: Recurrence Risk and Accidental Aggregation Study

1997 ◽  
Vol 24 (04) ◽  
pp. 326-331 ◽  
Author(s):  
Jean Mathieu ◽  
Gilles Hébert ◽  
Louis Pérusse ◽  
Claude Prévost ◽  
Léo Cantin ◽  
...  
Keyword(s):  
Risk Ratio ◽  
Genetic Predisposition ◽  
Intracranial Aneurysms ◽  
Familial Aggregation ◽  
Recurrence Risk ◽  
Population Based ◽  
Degree Relative ◽  
Ruptured Intracranial Aneurysm ◽  
Recurrence Risk Ratio ◽  
Risk Of Disease

ABSTRACT:Background:The Saguenay-Lac-Saint-Jean (SLSJ) region is a geographically isolated area (population 285,955) located in the Northeastern part of the Province of Quebec, Canada. Using a population-based register, the genealogical reconstruction of 502 individuals with ruptured intracranial aneurysm (RIA) showed a familial aggregation (the presence of aneurysm in two or more first- to third-degree relatives) for 144 (28.7%) of them; this proportion is much higher than reported elsewhere.Objective:In order to assess the genetic predisposition to RIA in the SLSJ population, the objective of the present study is to compare familial and non-familial cases and to provide an estimate of the recurrence risk ratio for siblings.Results:The age at the time of rupture, the number of intracranial aneurysms for each patient and the location of RIAs were not statistically different in the familial versus the non-familial group. Of the 3449 siblings, 20 (0.58%) had suffered a RIA. The recurrence risk ratio calculated for siblings (defined as the risk of disease among siblings divided by the estimated population prevalence) is 1.6 (CI 95% 1.0 - 2.4). In other respects, we observed very large kinships in the SLSJ population, with an average number of siblings of 7.2 (SD ± 3.4), ranging from 0 to 17 individuals. With such large families and on the basis of chance alone, we expected 31.3% of the patients to have at least one first- to third-degree relative with RIA.Conclusion:These data show that siblings of patients with RIA in the SLSJ population have a greater risk of RIA than the general population. Nevertheless, the largest part of the familial occurrence observed in the SLSJ region can be explained by accidental aggregation, due to large kinships. We propose that, in this population, an underlying genetic predisposition must be suspected only when three or more cases of RIA are identified among first- to third-degree relatives.

Familial risk of Hashimoto’s thyroiditis among first degree relatives, a population-based study in Korea

Thyroid ◽  
2021 ◽  
Author(s):  
Hyun Jung Kim ◽  
Sayada Zartasha Kazmi ◽  
Taeuk Kang ◽  
Seo Young Sohn ◽  
Dong-Sook Kim ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Familial Risk ◽  
Population Based ◽  
Hashimoto's Thyroiditis ◽  
Population Based Study ◽  
First Degree Relatives

scholarly journals Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: a recurrence risk ratio analysis

2004 ◽  
Vol 55 (10) ◽  
pp. 995-1000 ◽  
Author(s):  
Wei J Chen ◽  
Chin-Hao Chang ◽  
Shi K Liu ◽  
Tzung J Hwang ◽  
Hai-Gwo Hwu, collaborators from the
Keyword(s):  
Risk Ratio ◽  
Sustained Attention ◽  
Recurrence Risk ◽  
Attention Deficits ◽  
Ratio Analysis ◽  
Recurrence Risk Ratio ◽  
Schizophrenic Patients

scholarly journals Novel Insights into Plasmodium vivax Therapeutic Failure: CYP2D6 Activity and Time of Exposure to Malaria Modulate the Risk of Recurrence

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Ana Carolina Rios Silvino ◽  
Flora Satiko Kano ◽  
Marcelo Azevedo Costa ◽  
Cor Jesus Fernandes Fontes ◽  
Irene Silva Soares ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Risk Ratio ◽  
Recurrence Risk ◽  
Therapeutic Failure ◽  
Radical Cure ◽  
Cyp2d6 Activity ◽  
Content Type ◽  
Risk Of Recurrence ◽  
Malaria Exposure ◽  
Recurrence Risk Ratio

ABSTRACT Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic polymorphisms, leads to the therapeutic failure of PQ as a radical cure for P. vivax malaria. Here, we hypothesized that the host immune response to malaria parasites modulates susceptibility to P. vivax recurrences in association with CYP2D6 activity. We performed a 10-year retrospective study by genotyping CYP2D6 polymorphisms in 261 malaria-exposed individuals from the Brazilian Amazon. The immune responses against a panel of P. vivax blood-stage antigens were evaluated by serological assays. We confirmed our previous findings, which indicated an association between impaired CYP2D6 activity and a higher risk of multiple episodes of P. vivax recurrence (risk ratio, 1.75; 95% confidence interval [CI], 1.2 to 2.6; P = 0.0035). An important finding was a reduction of 3% in the risk of recurrence (risk ratio, 0.97; 95% CI, 0.96 to 0.98; P < 0.0001) per year of malaria exposure, which was observed for individuals with both reduced and normal CYP2D6 activity. Accordingly, subjects with long-term malaria exposure and persistent antibody responses to various antigens showed fewer episodes of malaria recurrence. Our findings have direct implications for malaria control, since it was shown that nonimmune individuals who do not respond adequately to treatment due to reduced CYP2D6 activity may present a significant challenge for sustainable progress toward P. vivax malaria elimination.

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