Familial risk of Hashimoto’s thyroiditis among first degree relatives, a population-based study in Korea

Thyroid ◽  
2021 ◽  
Author(s):  
Hyun Jung Kim ◽  
Sayada Zartasha Kazmi ◽  
Taeuk Kang ◽  
Seo Young Sohn ◽  
Dong-Sook Kim ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Familial Risk ◽  
Population Based ◽  
Hashimoto's Thyroiditis ◽  
Population Based Study ◽  
First Degree Relatives

scholarly journals Association between Hashimoto’s thyroiditis and cholelithiasis: a retrospective cohort study in Taiwan

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e020798
Author(s):  
Chien-Hua Chen ◽  
Cheng-Li Lin ◽  
Chia-Hung Kao
Keyword(s):  
Cohort Study ◽  
Relative Risk ◽  
Hashimoto’S Thyroiditis ◽  
Population Based ◽  
Secondary Outcome ◽  
Hashimoto's Thyroiditis ◽  
Rank Test ◽  
Study Cohort ◽  
Population Based Study ◽  
Log Rank Test

ObjectiveTo investigate the relation of Hashimoto’s thyroiditis (HT) to cholelithiasis and cholecystectomy in a retrospective population-based study.SettingCohort study.ParticipantsWe identified 1268 patients aged ≥20 years with HT between 2000 and 2010 as the study cohort.Primary and secondary outcome measuresPatients without HT were randomly selected from a database and propensity-matched with the study cohort at a 1:4 ratio according to age, sex, comorbidities and year of the index date to measure the incidence of cholelithiasis and cholecystectomy.ResultsThe cumulative incidence of cholelithiasis was higher in the HT cohort than that in the non-HT cohort (log-rank test, p<0.001), with a 1.91-fold higher risk of choleithiasis (95% CI 1.58 to 2.33) after adjustment for comorbidities. The age-specific relative risk of cholelithiasis in the HT cohort was higher than that in the non-HT cohort for patients aged ≥50 years (adjusted HR (aHR)=2.59, 95% CI 1.33 to 5.03). The sex-specific relative risk of cholelithiasis in the HT cohort was higher than that in the non-HT cohort for women (aHR=1.99, 95% CI 1.63 to 2.44). Compared with those in the non-HT cohort, patients with HT without (aHR=1.95, 95% CI 1.53 to 2.49) and with (aHR=1.94, 95% CI 1.51 to 2.49) thyroxine treatment were associated with a higher risk of cholelithiasis. Compared with those in the non-HT cohort, patients with HT had a higher risk of cholecystectomy (aHR=1.28, 95% CI 1.02 to 1.61).ConclusionsInability to obtain information on several potential confounding factors and misclassification of important covariates are the major limitations of the study. Our study indicates HT per se was associated with the development of cholelithiasis, which has been validated by the association between cholecystectomy and HT. Surveys and health education on cholelithiasis in women aged ≥50 years with HT should be considered by clinicians, and further prospective research should be done on this topic.

The making and unmaking of Hashimoto’s thyroiditis: On the mismatch between illness and disease. Results from an Italian study

2021 ◽  
pp. 136345932110483
Author(s):  
Mario Cardano ◽  
Eleonora Rossero
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Scientific Evidence ◽  
Systems Design ◽  
Population Based ◽  
Hashimoto's Thyroiditis ◽  
Diagnostic Process ◽  
Subjective Experiences ◽  
Ideal Types ◽  
Hierarchy Of Evidence ◽  
Illness And Disease

The diagnostic process in contemporary medical practice is increasingly technical, specialised and relying on population-based ranges of biological normalcy. Disease is defined according to a hierarchy of evidence that privileges specialist knowledge and marginalises subjective experiences of illness. Medical and individual definitions of the situation can conflict in two ways: (i) a diagnosis is made in the absence of symptoms, (ii) individual suffering does not constitute ‘real’ disease if it is not validated by scientific evidence. This article investigates how the discrepancy between specialist and embodied knowledge is experienced and tentatively solved by patients’ self-narratives. Starting from the analysis of 22 in-depth interviews with people affected by autoimmune diseases, we focus on the subgroup affected by Hashimoto’s thyroiditis. Applying the most-different-systems design, we confront two flesh-and-blood ideal-types of illness narratives characterised by a mismatch between illness and disease. Their diagnostic trajectories are outlined and discussed as poles of a continuum of experiences resulting from different configurations of medical evidence of disease and subjective evidence of illness.

scholarly journals A population-wide analysis of the familial risk of suicide in Utah, USA

2021 ◽  
pp. 1-10
Author(s):  
Amanda V. Bakian ◽  
Danli Chen ◽  
Chong Zhang ◽  
Heidi A. Hanson ◽  
Anna R. Docherty ◽  
...  
Keyword(s):  
Suicide Risk ◽  
Cox Regression ◽  
Familial Risk ◽  
Risk Groups ◽  
Population Based ◽  
Unified Framework ◽  
Population Database ◽  
First Degree Relatives ◽  
Hazard Ratios ◽  
History Of

Abstract Background The degree to which suicide risk aggregates in US families is unknown. The authors aimed to determine the familial risk of suicide in Utah, and tested whether familial risk varies based on the characteristics of the suicides and their relatives. Methods A population-based sample of 12 160 suicides from 1904 to 2014 were identified from the Utah Population Database and matched 1:5 to controls based on sex and age using at-risk sampling. All first through third- and fifth-degree relatives of suicide probands and controls were identified (N = 13 480 122). The familial risk of suicide was estimated based on hazard ratios (HR) from an unsupervised Cox regression model in a unified framework. Moderation by sex of the proband or relative and age of the proband at time of suicide (<25 v. ⩾25 years) was examined. Results Significantly elevated HRs were observed in first- (HR 3.45; 95% CI 3.12–3.82) through fifth-degree relatives (HR 1.07; 95% CI 1.02–1.12) of suicide probands. Among first-degree relatives of female suicide probands, the HR of suicide was 6.99 (95% CI 3.99–12.25) in mothers, 6.39 in sisters (95% CI 3.78–10.82), and 5.65 (95% CI 3.38–9.44) in daughters. The HR in first-degree relatives of suicide probands under 25 years at death was 4.29 (95% CI 3.49–5.26). Conclusions Elevated familial suicide risk in relatives of female and younger suicide probands suggests that there are unique risk groups to which prevention efforts should be directed – namely suicidal young adults and women with a strong family history of suicide.

Epidemiology and Familial Risk of Synchronous and Metachronous Colorectal Cancer: A Population-Based Study in Utah

2014 ◽  
Vol 12 (12) ◽  
pp. 2078-2084.e2 ◽  
Author(s):  
N. Jewel Samadder ◽  
Karen Curtin ◽  
Jathine Wong ◽  
Thérèse M.F. Tuohy ◽  
Geraldine P. Mineau ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Familial Risk ◽  
Population Based ◽  
Population Based Study ◽  
Metachronous Colorectal Cancer

scholarly journals Association of Hemorrhoids With Hashimoto's Thyroiditis and Associated Comorbidities: A Nationwide Population-Based Cohort Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Sheng-Pang Hsu ◽  
Hsin-Hung Chen ◽  
Tzu-Yuan Wang ◽  
Chun-Wei Ho ◽  
Ming-Chia Hsieh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hashimoto’S Thyroiditis ◽  
Population Based ◽  
Hashimoto's Thyroiditis

scholarly journals Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

2005 ◽  
Vol 94 (2) ◽  
pp. 231-238 ◽  
Author(s):  
H M Verkooijen ◽  
P O Chappuis ◽  
E Rapiti ◽  
G Vlastos ◽  
G Fioretta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Familial Risk ◽  
Population Based ◽  
Early Onset Breast Cancer ◽  
Population Based Study ◽  
Familial Risk Factors
Sign in / Sign up

Export Citation Format

Share Document