Optimal cut-off age in the TNM Staging system of differentiated thyroid cancer: is 55 years better than 45 years?

2016 ◽  
Vol 86 (3) ◽  
pp. 438-443 ◽  
Author(s):  
Mijin Kim ◽  
Young Nam Kim ◽  
Won Gu Kim ◽  
Suyeon Park ◽  
Hyemi Kwon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Better Than

scholarly journals Comparison of long-term prognosis for differentiated thyroid cancer according to the 7th and 8th editions of the AJCC/UICC TNM staging system

2020 ◽  
Vol 11 ◽  
pp. 204201882092101 ◽  
Author(s):  
Kwangsoon Kim ◽  
Jin Kyong Kim ◽  
Cho Rok Lee ◽  
Sang-Wook Kang ◽  
Jandee Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Disease Free Survival ◽  
Staging System ◽  
Tnm Staging ◽  
University Hospital ◽  
Tnm Staging System ◽  
Staging Systems ◽  
8Th Edition

Background: The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system was released with major revisions. The purpose of this retrospective study was to investigate differences between the 7th and 8th editions of the AJCC/UICC TNM staging system and to compare the predictability of prognosis between the two staging systems with patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) at a single institution. Methods: A total of 3238 patients underwent thyroid operation from January 2002 to December 2006 at Yonsei University Hospital (Seoul, Korea), of which 2294 with complete clinical data and sustained follow up were enrolled. Clinicopathologic features and TNM staging by applying the 7th and 8th editions of the AJCC/UICC were analyzed retrospectively by the complete review of medical charts and pathology reports of patients. Mean follow-up duration was 132.9 ± 27.9 months. Results: A significant number of T3 patients were downstaged to T1 (838, 36.5%) and T2 (122, 5.3%). After applying the 8th edition of the AJCC/UICC TNM staging system, the number of stage I patients increased significantly from 1434 (62.5%) to 2058 (89.7%), whereas numbers of stage III and IV patients decreased significantly from 644 (28.1%) to 33 (1.4%) and from 199 (8.7%) to 17 (0.7%), respectively. According to Kaplan–Meier survival analyses and values of the Harrell’s c-index and integrated area under the curve (iAUC), the 8th edition has significantly better predictive performance for disease-free survival (DFS) and disease-specific survival (DSS) than the 7th edition. Conclusions: A significant population was downstaged after applying the 8th edition of the AJCC/UICC TNM staging system, and the 8th edition provided significantly better accuracy in predicting DFS and DSS in patients with DTC.

Improved prognostic value of the eighth edition of the AJCC/TNM staging system for differentiated thyroid cancer

2018 ◽  
Author(s):  
Velsen Evert van ◽  
Merel Stegenga ◽  
Kemenade Folkert van ◽  
Boen Kam ◽  
Ginhoven Tessa van ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Value ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Eighth Edition

scholarly journals Impacts of the American Joint Committee on Cancer (AJCC) 8th edition tumor, node, metastasis (TNM) staging system on outcomes of differentiated thyroid cancer in Thai patients

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06624
Author(s):  
Yotsapon Thewjitcharoen ◽  
Waralee Chatchomchuan ◽  
Krittadhee Karndumri ◽  
Sriurai Porramatikul ◽  
Sirinate Krittiyawong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tumor Node Metastasis ◽  
Node Metastasis ◽  
American Joint Committee ◽  
Tnm Staging System ◽  
8Th Edition

The Updated AJCC/TNM Staging System for Papillary Thyroid Cancer (8th Edition): From the Perspective of Genomic Analysis

2018 ◽  
Vol 42 (11) ◽  
pp. 3624-3631 ◽  
Author(s):  
Kyubo Kim ◽  
Jin Hwan Kim ◽  
Il Seok Park ◽  
Young Soo Rho ◽  
Gee Hwan Kwon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Genomic Analysis ◽  
Staging System ◽  
Tnm Staging ◽  
Papillary Thyroid ◽  
Tnm Staging System ◽  
8Th Edition

Finding the Optimal Age Cutoff for the UICC/AJCC TNM Staging System in Patients with Papillary or Follicular Thyroid Cancer

Thyroid ◽  
2021 ◽  
Author(s):  
Evert F.S. van Velsen ◽  
W. Edward Visser ◽  
Merel Tessa Stegenga ◽  
Uwe Maeder ◽  
Christoph Reiners ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Follicular Thyroid Cancer ◽  
Tnm Staging System

HOW DOES THE AJCC/TNM STAGING SYSTEM 8TH EDITION PERFORM IN THYROID CANCER AT A MAJOR MIDDLE EASTERN MEDICAL CENTER?

2020 ◽  
Author(s):  
Ali S. Alzahrani ◽  
Lina Albalawi ◽  
Sedra Mazi ◽  
Noha Mukhtar ◽  
Hadeel AlJamei ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medical Center ◽  
Middle Eastern ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
8Th Edition

scholarly journals The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging

2018 ◽  
Vol 9 ◽  
Author(s):  
Claudio Casella ◽  
Silvia Ministrini ◽  
Alessandro Galani ◽  
Francesco Mastriale ◽  
Carlo Cappelli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Risk Of Disease

scholarly journals Strap muscle invasion in differentiated thyroid cancer does not impact disease-specific survival: a population-based study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ja Kyung Yoon ◽  
Jandee Lee ◽  
Eun-Kyung Kim ◽  
Jung Hyun Yoon ◽  
Vivian Youngjean Park ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Disease Specific Survival ◽  
Strap Muscle ◽  
Muscle Invasion ◽  
The Impact ◽  
Multivariable Adjustment ◽  
Disease Specific

Abstract The American Joint Committee on Cancer (AJCC) 8th TNM staging system of differentiated thyroid cancer defines gross strap muscle invasion as T3b stage. However, the impact of strap muscle invasion on disease-specific survival (DSS) remains controversial. To elucidate the survival impact of strap muscle invasion of any degree in thyroid cancers, the Surveillance, Epidemiology, and End Results (SEER) database (1973–2018) was queried for thyroid cancer only patients on July 2019 (n = 19,914). The Cox proportional hazard analysis with multivariable adjustment revealed that strap muscle invasion was not a significant factor for DSS in tumors equal to or smaller than 40 mm (hazard ratio (HR) = 1.620 [confidence interval (CI) 0.917 – 2.860]; p = 0.097). The competing risk analysis with multivariable adjustment showed that strap muscle invasion did not significantly impact DSS regardless of tumor size or cause of death (cancer-caused death (Subdistribution HR (SDHR) = 1.567 [CI 0.984 – 2.495]; p = 0.059); deaths to other causes (SDHR = 1.155 [CI 0.842 – 1.585]; p = 0.370). A “modified” staging schema discarding strap muscle invasion as a T stage criterion showed better 10-year DSS distinction between T stages. The modified staging schema may better reflect cancer-caused death risk and may prevent potential overstaging.

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