Prognostic effects ofTERTpromoter mutations are enhanced by coexistence withBRAForRASmutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients

Cancer ◽  
2016 ◽  
Vol 122 (9) ◽  
pp. 1370-1379 ◽  
Author(s):  
Young Shin Song ◽  
Jung Ah Lim ◽  
Hoonsung Choi ◽  
Jae-Kyung Won ◽  
Jae Hoon Moon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Risk Prediction ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System

scholarly journals Comparison of long-term prognosis for differentiated thyroid cancer according to the 7th and 8th editions of the AJCC/UICC TNM staging system

2020 ◽  
Vol 11 ◽  
pp. 204201882092101 ◽  
Author(s):  
Kwangsoon Kim ◽  
Jin Kyong Kim ◽  
Cho Rok Lee ◽  
Sang-Wook Kang ◽  
Jandee Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Disease Free Survival ◽  
Staging System ◽  
Tnm Staging ◽  
University Hospital ◽  
Tnm Staging System ◽  
Staging Systems ◽  
8Th Edition

Background: The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system was released with major revisions. The purpose of this retrospective study was to investigate differences between the 7th and 8th editions of the AJCC/UICC TNM staging system and to compare the predictability of prognosis between the two staging systems with patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) at a single institution. Methods: A total of 3238 patients underwent thyroid operation from January 2002 to December 2006 at Yonsei University Hospital (Seoul, Korea), of which 2294 with complete clinical data and sustained follow up were enrolled. Clinicopathologic features and TNM staging by applying the 7th and 8th editions of the AJCC/UICC were analyzed retrospectively by the complete review of medical charts and pathology reports of patients. Mean follow-up duration was 132.9 ± 27.9 months. Results: A significant number of T3 patients were downstaged to T1 (838, 36.5%) and T2 (122, 5.3%). After applying the 8th edition of the AJCC/UICC TNM staging system, the number of stage I patients increased significantly from 1434 (62.5%) to 2058 (89.7%), whereas numbers of stage III and IV patients decreased significantly from 644 (28.1%) to 33 (1.4%) and from 199 (8.7%) to 17 (0.7%), respectively. According to Kaplan–Meier survival analyses and values of the Harrell’s c-index and integrated area under the curve (iAUC), the 8th edition has significantly better predictive performance for disease-free survival (DFS) and disease-specific survival (DSS) than the 7th edition. Conclusions: A significant population was downstaged after applying the 8th edition of the AJCC/UICC TNM staging system, and the 8th edition provided significantly better accuracy in predicting DFS and DSS in patients with DTC.

Improved prognostic value of the eighth edition of the AJCC/TNM staging system for differentiated thyroid cancer

2018 ◽  
Author(s):  
Velsen Evert van ◽  
Merel Stegenga ◽  
Kemenade Folkert van ◽  
Boen Kam ◽  
Ginhoven Tessa van ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Value ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Eighth Edition

scholarly journals Impacts of the American Joint Committee on Cancer (AJCC) 8th edition tumor, node, metastasis (TNM) staging system on outcomes of differentiated thyroid cancer in Thai patients

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06624
Author(s):  
Yotsapon Thewjitcharoen ◽  
Waralee Chatchomchuan ◽  
Krittadhee Karndumri ◽  
Sriurai Porramatikul ◽  
Sirinate Krittiyawong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tumor Node Metastasis ◽  
Node Metastasis ◽  
American Joint Committee ◽  
Tnm Staging System ◽  
8Th Edition

Optimal cut-off age in the TNM Staging system of differentiated thyroid cancer: is 55 years better than 45 years?

2016 ◽  
Vol 86 (3) ◽  
pp. 438-443 ◽  
Author(s):  
Mijin Kim ◽  
Young Nam Kim ◽  
Won Gu Kim ◽  
Suyeon Park ◽  
Hyemi Kwon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Better Than

The Updated AJCC/TNM Staging System for Papillary Thyroid Cancer (8th Edition): From the Perspective of Genomic Analysis

2018 ◽  
Vol 42 (11) ◽  
pp. 3624-3631 ◽  
Author(s):  
Kyubo Kim ◽  
Jin Hwan Kim ◽  
Il Seok Park ◽  
Young Soo Rho ◽  
Gee Hwan Kwon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Genomic Analysis ◽  
Staging System ◽  
Tnm Staging ◽  
Papillary Thyroid ◽  
Tnm Staging System ◽  
8Th Edition

Finding the Optimal Age Cutoff for the UICC/AJCC TNM Staging System in Patients with Papillary or Follicular Thyroid Cancer

Thyroid ◽  
2021 ◽  
Author(s):  
Evert F.S. van Velsen ◽  
W. Edward Visser ◽  
Merel Tessa Stegenga ◽  
Uwe Maeder ◽  
Christoph Reiners ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Follicular Thyroid Cancer ◽  
Tnm Staging System

HOW DOES THE AJCC/TNM STAGING SYSTEM 8TH EDITION PERFORM IN THYROID CANCER AT A MAJOR MIDDLE EASTERN MEDICAL CENTER?

2020 ◽  
Author(s):  
Ali S. Alzahrani ◽  
Lina Albalawi ◽  
Sedra Mazi ◽  
Noha Mukhtar ◽  
Hadeel AlJamei ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medical Center ◽  
Middle Eastern ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
8Th Edition

scholarly journals The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging

2018 ◽  
Vol 9 ◽  
Author(s):  
Claudio Casella ◽  
Silvia Ministrini ◽  
Alessandro Galani ◽  
Francesco Mastriale ◽  
Carlo Cappelli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Risk Of Disease

scholarly journals Is Preoperative Fibrinogen Associated with the Survival Prognosis of Gastric Cancer Patients? A Multi-centered, Propensity Score-Matched Retrospective Study

2019 ◽  
Vol 44 (1) ◽  
pp. 213-222
Author(s):  
Lin-Yong Zhao ◽  
Yong-Liang Zhao ◽  
Jun-Jiang Wang ◽  
Qi-Di Zhao ◽  
Wen-Qi Yi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Propensity Score ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Staging System ◽  
Tnm Staging ◽  
Plasma Fibrinogen ◽  
Tnm Staging System ◽  
N Stage ◽  
Gastric Cancer Patients

Abstract Background The prognostic significance of preoperative plasma fibrinogen in patients with operable gastric cancer remains under debate. This study aimed to elucidate the prognostic value of fibrinogen in gastric cancer patients underwent gastrectomy. Methods A total of 4351 patients with gastric cancer collected from three comprehensive medical centers were retrospectively evaluated. Patients were categorized by minimum P value using X-tile, while the baseline confounders for fibrinogen was balanced through propensity score matching (PSM). The relationships between fibrinogen and other clinicopathologic features were evaluated, and nomogram was constructed to assess its prognostic improvement compared with TNM staging system. Results Fibrinogen was significantly correlated with macroscopic type, tumor differentiation, tumor size, and T and N stage. The factors, fibrinogen and T stage as well as N stage, were identified to be independent prognostic factors after PSM. Nomogram based on fibrinogen demonstrated a smaller Akaike information criterion (AIC) and a larger concordance index (C-index) than TNM staging system, illustrating that fibrinogen might be able to improve the prognostic accuracy. Conclusions Preoperative plasma fibrinogen levels in gastric cancer patients were significantly correlated with tumor progression, which could be regarded as a reliable marker for survival prognostic prediction.

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