Addison's disease with polyglandular autoimmunity carries a more than 2·5-fold risk for adrenal crises: German Health insurance data 2010-2013

2016 ◽  
Vol 85 (3) ◽  
pp. 347-353 ◽  
Author(s):  
Gesine Meyer ◽  
Klaus Badenhoop ◽  
Roland Linder
Keyword(s):  
Health Insurance ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Health Insurance Data ◽  
German Health ◽  
Insurance Data ◽  
Polyglandular Autoimmunity

scholarly journals Increasing prevalence of Addison's disease in German females: health insurance data 2008–2012

2014 ◽  
Vol 170 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Gesine Meyer ◽  
Kathrin Neumann ◽  
Klaus Badenhoop ◽  
Roland Linder
Keyword(s):  
Health Insurance ◽  
Routine Data ◽  
Addison’S Disease ◽  
Epidemiological Studies ◽  
Steady Increase ◽  
Addison's Disease ◽  
German Population ◽  
Health Insurance Data ◽  
Pronounced Increase ◽  
Insurance Data

ObjectiveOur objective was to investigate the epidemiology of autoimmune Addison's disease (AD) in Germany.DesignRoutine data were analyzed from the Statutory Health Insurance (SHI) database of the Techniker Krankenkasse (TK) for an observation period from 01/01/2008 to 31/12/2012. The TK is one of the largest German health care insurance providers covering more than 10% of the German population.Subjects and methodsBetween 2008 and 2012, a total of 2477 diagnoses of primary adrenal failure were recorded in the SHI database. After exclusion of secondary, iatrogenic or other non-idiopathic forms and after adjustment for incomplete data sets, 1364 diagnoses of autoimmune-mediated AD remained.ResultsThe prevalence of AD in our cohort showed a steady increase from 82 per million in 2008 to 87 per million in 2012. On average, the prevalence rose about 1.8% per year, and due to a pronounced increase (2.7%) in females. The prevalence was lower in men (63–68 per million) than in women (96–108 per million). Autoimmune comorbidities were found in 46.5% of AD patients. Adrenal crises were documented with a frequency of 14–17/100 patient years.ConclusionsThese data provide a first epidemiological profile of this rare and perilous endocrine disease in Germany. Although the prevalence of AD appears lower than in the Scandinavian countries, the increasing figures in females over the last 5 years warrant further investigations. Furthermore, adrenal crises pose a considerable burden. Hereby, we can show that health insurance data provide a valuable tool for epidemiological studies in the absence of national registries.

Cancer risk from nitrosamine-contaminated valsartan

2021 ◽  
pp. dtb-2021-000041
Keyword(s):  
Cohort Study ◽  
Health Insurance ◽  
Cancer Risk ◽  
Longitudinal Cohort Study ◽  
Health Insurance Data ◽  
Longitudinal Cohort ◽  
German Health ◽  
Insurance Data

AbstractOverview of: Gomm W, Röthlein C, Bowl K, et al. Valsartan contaminated with N-nitrosodimethylamine and cancer risk: a longitudinal cohort study with German health insurance data. Dtsch Arztebl Int 2021; 118:357–62. doi: 10.3238/arztebl.m2021.0129.

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