Pelvic ultrasound findings in prepubertal girls with precocious adrenarche born appropriate for gestational age

2013 ◽  
Vol 80 (5) ◽  
pp. 699-705 ◽  
Author(s):  
Ahmet Uçar ◽  
Oğuz Bulent Erol ◽  
Ensar Yekeler ◽  
Ismail Yildiz ◽  
Serdar Bozlak ◽  
...  
Keyword(s):  
Gestational Age ◽  
Pelvic Ultrasound ◽  
Ultrasound Findings ◽  
Precocious Adrenarche ◽  
Appropriate For Gestational Age ◽  
Prepubertal Girls

Precocious adrenarche in children born appropriate for gestational age: is there a difference between genders?

2012 ◽  
Vol 171 (11) ◽  
pp. 1661-1666 ◽  
Author(s):  
Ahmet Uçar ◽  
Nurçin Saka ◽  
Firdevs Baş ◽  
Rüveyde Bundak ◽  
Hülya Günöz ◽  
...  
Keyword(s):  
Gestational Age ◽  
Precocious Adrenarche ◽  
Appropriate For Gestational Age

scholarly journals Associations of Size at Birth and Postnatal Catch-up Growth Status With Clinical and Biomedical Characteristics in Prepubertal Girls With Precocious Adrenarche: Preliminary Results

2014 ◽  
Vol 99 (8) ◽  
pp. 2878-2886 ◽  
Author(s):  
Ahmet Uçar ◽  
Michal Yackobovitch-Gavan ◽  
Oğuz Bülent Erol ◽  
Ensar Yekeler ◽  
Nurçin Saka ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Gestational Age ◽  
Serum Insulin ◽  
Bone Age ◽  
Precocious Adrenarche ◽  
Catch Up ◽  
Prepubertal Girls ◽  
Size At Birth

Context: The causes of polycystic ovarian syndrome (PCOS) in girls with precocious adrenarche (PA) remain unclear. Objective: Our goal was to compare the clinical, biochemical, and ultrasound characteristics of girls with PA whose size at birth was appropriate for gestational age (AGA) vs those born small for gestational age (SGA). PCOS-associated metabolic and morphological correlates were examined. Design: Glucose tolerance, ACTH stimulation, and transabdominal ultrasounds were examined in 56 AGA and 31 SGA girls with PA. Bone age and hormonal profiles were determined. SGA girls were divided into 2 groups by catch-up growth (CUG) status. Subgroups were compared. Results: Chronological age, Tanner stage for pubarche, ovarian volume, and uterine volume were similar between the groups. SGA girls had lower body mass index and higher bone age-adjusted post-corticotropin cortisol. We found increased body mass index-adjusted mean serum insulin, reduced insulin sensitivity, and reduced IGF-binding protein-1 in SGA girls. Multicystic ovaries were more common in SGA girls (odds ratio [OR] = 9.69, 95% confidence interval [CI] = 3.34–28.15; P < .001). SGA girls without CUG had a higher incidence of multicystic ovaries than CUG counterparts (OR = 8.4, 95% CI = 1.4–19.3; P = .027). Being born SGA (OR = 43.4, 95% CI = 6.9–84.7; P = .001] and exaggerated 17-hydroxyprogesterone response (OR = 15.8, 95% CI = 1.7–49.8; P = .015) were associated with multicystic ovaries. Conclusions: Significant differences in hormone levels, insulin sensitivity, and ovarian maturity were found in prepubertal girls with PA who were SGA. Longitudinal follow-up will help determine whether these factors contribute to a specific PCOS phenotype in SGA girls with PA.

scholarly journals Reduced atherogenic indices in prepubertal girls with precocious adrenarche born appropriate for gestational age in relation to the conundrum of DHEAS

2013 ◽  
Vol 2 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Ahmet Uçar ◽  
Nurçin Saka ◽  
Firdevs Baş ◽  
Nihal Hatipoğlu ◽  
Rüveyde Bundak ◽  
...  
Keyword(s):  
Gestational Age ◽  
Plasma Lipids ◽  
University Hospital ◽  
Atherogenic Index ◽  
Oral Glucose ◽  
Model Assessment ◽  
Metabolic Complications ◽  
Increased Risk ◽  
Precocious Adrenarche ◽  
Appropriate For Gestational Age

Context An association between low birth weight, insulin resistance (IR), dyslipidemia, and atherogenesis has been shown in girls with precocious adrenarche (PA). Objective To evaluate whether girls with PA born appropriate for gestational age (AGA) have increased risk for metabolic complications at initial evaluation. Design/methods We conducted a cross-sectional study on 69 AGA born girls with PA (mean (±s.d.) age 7.1±1 years) and 45 body mass index (BMI)- and waist circumference (WC)-matched prepubertal peers born AGA (mean (±s.d.) 7.5±1.9 years). A standard 2-h oral glucose tolerance test with insulin sampling was performed. Fasting plasma lipids and high-sensitivity C-reactive protein were analyzed, and blood pressure was recorded. Insulin sensitivity (IS) index (ISIcomp), homeostasis model assessment of IR, and atherogenic index (AI) (triglycerides/high-density lipoprotein cholesterol) were calculated. Setting The study was performed at University Hospital. Results AI was significantly lower in girls with PA than in controls (P<0.001), and it was correlated with BMI SDS (r=0.44, P=0.001) and WC (r=0.39, P=0.001). The significant correlation of AI with ISIcomp (r=−0.38, P=0.001) disappeared after correcting for BMI (r=−0.185, P=0.16). Multivariate regression analysis revealed that DHEAS was the only significant parameter influencing AI in girls with born AGA (R 2=0.475 β=−0.018, P=0.0001). Conclusions Metabolic screening in prepubertal AGA born girls with PA may yield favorable lipid profiles. AI in girls with PA is increased in relation to decreasing IS and increasing BMI and WC. DHEAS seems to have the most significant effect on AI.

Interrelationship of Extent of Precocious Adrenarche in Appropriate for Gestational Age Girls with Clinical Outcome

2012 ◽  
Vol 160 (2) ◽  
pp. 308-313 ◽  
Author(s):  
Tal Oron ◽  
Yael Lebenthal ◽  
Liat de Vries ◽  
Michal Yackobovitch-Gavan ◽  
Moshe Phillip ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Gestational Age ◽  
Precocious Adrenarche ◽  
Appropriate For Gestational Age

Serum kallistatin level is decreased in women with preeclampsia

2021 ◽  
Vol 49 (1) ◽  
pp. 60-66
Author(s):  
Onur Güralp ◽  
Nevin Tüten ◽  
Koray Gök ◽  
Kübra Hamzaoglu ◽  
Huri Bulut ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Gestational Age ◽  
Late Onset ◽  
Serine Proteinase ◽  
Serum Levels ◽  
Control Group ◽  
Positive Correlation ◽  
Uncomplicated Pregnancy ◽  
Appropriate For Gestational Age

AbstractObjectivesTo evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).MethodsThe clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.ResultsMean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.ConclusionsSerum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.

Propensity-Matched Comparison of Very Preterm Small- and Appropriate-for-Gestational-Age Neonates

2021 ◽  
Author(s):  
Rajendra Prasad Anne ◽  
Venkateshwarulu Vardhelli ◽  
Tejo Pratap Oleti ◽  
Srinivas Murki ◽  
Gopireddy Murali Mohan Reddy ◽  
...  
Keyword(s):  
Gestational Age ◽  
Very Preterm ◽  
Appropriate For Gestational Age ◽  
Matched Comparison

Pelvic ultrasound findings in different forms of sexual precocity

1995 ◽  
Vol 84 (5) ◽  
pp. 544-549 ◽  
Author(s):  
IJ Griffin ◽  
TJ Cole ◽  
KA Duncan ◽  
AS Hollman ◽  
MDC Donaldson
Keyword(s):  
Pelvic Ultrasound ◽  
Sexual Precocity ◽  
Ultrasound Findings
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